关键词: 脑梗死, 血管内皮生长因子, 降钙素原, 高敏C反应蛋白, 脑水肿

Abstract:

Objective To explore the relationship between the expression of serum vascular endothelial growth factor(VEGF), procalcitonin(PCT), high-sensitivity C-reactive protein(hs-CRP) and the severity of cerebral edema in patients with acute cerebral infarction(ACI). Methods A total of 102 ACI patients diagnosed in our hospital were selected, the patients were divided into a mild group (n=34), moderate group(n=42) severe group(n=26) according to the National Institutes of Health Stroke Scale(NIHSS). The disturbance coefficient values of cerebral electrical impedance(CEI) of the affected cerebral hemisphere was detected, aiming to compare the disturbance coefficient values of serum VEGF, PCT, hs-CRP and CEI in each group, and analyze the correlation among these values. Results Repeated measurements showed that the disturbance coefficient values of serum VEGF, PCT, hs-CRP, and affected side CEI were statistically significant in terms of time point, between groups, interaction of time point and between groups (P<0.05); the disturbance coefficient values of affected side CEI was positively correlated with the level of serum VEGF, PCT, and hs-CRP (P<0.05). Conclusion The more severe the condition of ACI patients, the higher the level of serum VEGF, PCT, hs-CRP, and the higher the CEI disturbance coefficient values on the affected side CIE. Serum VEGF, PCT, hs-CRP are closely related to the degree of cerebral edema, and may be involved in the occurrence and development of cerebral edema in ACI , it can play an early auxiliary role on evaluating the condition and the severity of cerebral edema.

Key words: brain infarction, vascular endothelial growth factor, procalcitonin, high-sensitivity C-reactive protein, cerebral edema