临床荟萃

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少见诱因引起的吉兰-巴雷综合征临床研究

  

  1. 1.沈阳军区总医院 神经内科,辽宁 沈阳   110016;2.铁岭卫生职业学院,辽宁 铁岭 112008
  • 出版日期:2016-12-05 发布日期:2016-12-01
  • 通讯作者: 通信作者:夏程, Email:xiacheng1975@sina.com
  • 基金资助:
    辽宁省科学技术计划项目(2015010417)

Clinical observation in rare causes of GuillainBarré syndrome

  1. 1.Department of Neurology, General Hospital of Shenyang Military Area Command,
    Shenyang 110016, China;2.Tieling Health Vocational College, Tieling 112008, China
  • Online:2016-12-05 Published:2016-12-01
  • Contact: Corresponding author: Xia Cheng, Email: xiacheng1975@sina.com

摘要: 目的研究少见诱因引起的吉兰巴雷综合征(GuillainBarré syndrome,GBS)的临床特点,提高对少见诱因引起的GBS的认识。方法回顾性分析9例少见诱因引起的GBS患者临床特点、治疗及预后。结果患者男8例,女1例,年龄16~80岁,诱因分别为眼外伤1例,戊型肝炎感染1例,流行性出血热感染1例,腰椎术后2例,头外伤2例,糖尿病酮症酸中毒(diabetic ketoacidosis,DKA) 2例。结论GBS可由外伤、戊型肝炎感染、流行性出血热病毒感染、DKA及手术所诱发,多发生上述诱因后5~14天,发病10~21天内病情达高峰。早期给予免疫球蛋白等治疗,绝大多数预后相对良好,目前发病机制尚不清楚。

关键词: 格林巴利综合征, 感染, 糖尿病酮症酸中毒, 外伤, 外科手术

Abstract: ObjectiveTo study the rare causes of GuillainBarré syndrome(GBS). MethodsA total of 9 rare cases of GBS were retrospectively analyzed. ResultsAll 9 cases ranged from 16 to 80 years old, included 8 males and 1 female, the causes of GBS were 1 case of eye trauma,1 case of hepatitis E virus infection,1 case of epidemic hemorrhagic fever, 2 cases of lumbar surgery, 2 cases of head trauma and 2 cases of diabetic ketoacidosis. ConclusionGBS was triggered by trauma, hepatitis E virus infection, epidemic hemorrhagic fever, diabetic ketoacidosis, and surgery after 5 to 14 days prior to symptom onset, the illness reached its peak after onset of 10 to 21 days. The prognosis was relatively good if given treatment of immunglobulin in the early stage of disease, but the pathogenesis of rare causes of GBS was unclear.

Key words: GuillainBarré, syndrome, infection, diabetic ketoacidosis, tranma, surgical procedures operative