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老年人低密度脂蛋白胆固醇与死亡率相关的meta分析

  

  1. 1.玉溪市人民医院 科教科,云南 玉溪 653100;2.邯郸市中医院 急诊科,河北 邯郸  056001
  • 出版日期:2017-09-05 发布日期:2017-09-08
  • 通讯作者: 通信作者:刘建伟,Email: 136916407@qq.com

Lowdensity lipoprotein cholesterol and mortality in the elderly--a meta analysis

  1. 1.Department of Science and Education,  Yuxi People’s Hospital,  Yuxi 653000,  China;
    2. Department of Emergency,  Traditional Chinese Medicine Hospital  of Handan,  Handan 056001,  China
  • Online:2017-09-05 Published:2017-09-08
  • Contact: Corresponding author: Liu Jianwei, Email: 136916407@qq.com

摘要: 目的   系统评价老年人低密度脂蛋白胆固醇(LDLC)与死亡率之间的关系。方法  检索PubMed数据库、Cochrane临床试验数据库、中国知网CNKI、中国生物医学文献数据库CBM和万方数据库,检索时间从建库至2016年12月。筛选队列研究,且含有OR值及95%CI或可通过相关数据计算。结果  本次meta分析共纳入5篇文献,共包含50  361例,高LDLC作为参照组含3篇文章,RR=1.405,95%CI=1.206~1.635,P<0.01,低LDLC作为参照组含2篇文章,RR=0.552,95%CI=0.506~0.602,P<0.01,不同浓度分析发现,老年人死亡风险随LDLC浓度升高或降低呈反方向变化。结论  老年人LDLC与死亡率之间存在负相关。

关键词: 冠状动脉疾病, 低密度脂蛋白胆固醇, 因素, 统计学, 老年人, 死亡率

Abstract: Objective  To systematically evaluate the association between lowdensity lipoprotein cholesterol (LDLC) and mortality.Methods  The Pubmed, Cochrane Library, CNKI, CBM and Wangfang databases were searched from building databases to December 2016. The enrollment involved screening cohort studies with OR values and 95% CI or the relevant data which can be calculated.Results  Five studies with 50 361 participants were finally included. High LDLC as reference: the pooled RR was  1.405(95%CI=1.2061.635,P<0.01). Low LDLC as reference: the pooled RR was 0.552 (95%CI=0.5060.602,P<0.01). With the change of LDLC, the risk of mortality became inverse. Conclusion  High LDLC is inversely  associated with the allcause mortality in the elderly.

Key words: coronary artery disease, lowdensity lipoprotein cholesterol, elderly, mortality