二丁酰环磷腺苷钙预防多柔比星化疗后亚急性心脏毒性的临床研究

doi:10.3969/j.issn.1004-583X.2017.12.009

临床荟萃

二丁酰环磷腺苷钙预防多柔比星化疗后亚急性心脏毒性的临床研究

庆阳市人民医院中西医结合科，甘肃庆阳 745000

出版日期:2017-12-05 发布日期:2017-12-14
通讯作者: 通信作者：缪延栋，Email：miaoyandong11@126.com

Clinical study of calcium dibutyryladenosine cyclophosphate in prevention of subacute cardiotoxicity induced by doxorubicin chemotherapy

Department of Integrated Traditional and Western Medicine， the People’s Hospital
of Qingyang， Qingyang 745000， China

Online:2017-12-05 Published:2017-12-14
Contact: Corresponding author: Miao Yandong， Email: miaoyandong11@126.com

摘要/Abstract

摘要： 目的观察二丁酰环磷腺苷钙预防多柔比星多疗程化疗所致亚急性心脏毒性的疗效。方法将乳腺癌、非霍奇金淋巴瘤患者47例，随机分为两组，实验组24例，对照组23例，实验组采用化疗联合使用注射用二丁酰环磷腺苷钙;对照组单纯采用含多柔比星的化疗方案.两组患者均按要求完成4周期化疗，观察两组化疗前48小时、2周期化疗后1周、4周期化疗后1周心电图及左心室射血分数（LVEF），N端B型脑钠肽前体（NTproBNP），心肌肌钙蛋白I （cTnI），肌酸激酶同工酶（CKMB）的变化。结果实验组2周期及4周期化疗后心电图的异常率、LVEF下降百分比、cTnI、NTproBNP和CKMB的水平升高均小于对照组（P<0.05）。结论注射用二丁酰环磷腺苷钙可以减轻多柔比星多疗程化疗所致的亚急性心脏毒性。

关键词: 乳腺肿瘤, 淋巴瘤, 心脏毒素类, 多柔比星, 二丁酰环磷腺苷钙

Abstract: Objective To observe the protective effect of calcium dibutyryladenosine cyclophosphate in subacute cardiotoxicity induced by doxorubicin chemotherapy. Methods Totally 47 cases of breast cancer and lymphoma were randomly divided into control group(n=23) and treatment group(n=24). Both groups received the chemotherapy regimens containing doxorubicin and the treatment group had an addition injection of calcium dibutyryladenosine cyclophosphate. Both groups received four complete cycles of chemotherapy. The ECG changes， echocardiography (left ventricular ejection fraction， LVEF)， Nterminal probrain natriuretic peptide (NTproBNP)， cardiac troponin I (cTnI) and CKMB values in both groups were observed before the chemotherapy and after two and four cycle chemotherapy.Results Upon comparing the ECG changes， LVEF， cTnI， NTproBNP and CKMB values of both groups before 48 hours of the chemotherapy and after one week of two and four cycle chemotherapy， treatment group had lesser incidence rates in abnormal ECG， decreased LVEF， increased cTnI， NTproBNP and CKMB (P<0.05). Conclusion Calcium dibutyryladenosine cyclophosphate may reduce the cardiotoxicity induced by doxorubicin chemotherapy.

Key words: breast neoplasms, lymphoma, cardiotoxins, doxorubicin, calcium dibutyryladenosini cyclophosphas

缪延栋，全无瑕. 二丁酰环磷腺苷钙预防多柔比星化疗后亚急性心脏毒性的临床研究[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2017.12.009.

Miao Yandong， Quan Wuxia. Clinical study of calcium dibutyryladenosine cyclophosphate in prevention of subacute cardiotoxicity induced by doxorubicin chemotherapy[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2017.12.009.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2017.12.009

https://huicui.hebmu.edu.cn/CN/Y2017/V32/I12/1053

[1]	陈思晗, 熊虎, 税典雅, 高小瞻, 刘泽伟. 超微血管成像技术诊断乳腺肿瘤的meta分析[J]. 临床荟萃, 2024, 39(2): 108-114.
[2]	刘丽丽, 袁宇婷, 赖耿良, 田川, 蓝翔, 叶中绿. 儿童急性淋巴细胞白血病第15天微小残留与预后的关系[J]. 临床荟萃, 2024, 39(1): 47-52.
[3]	杨巍, 何晨冬. 以干咳为唯一症状的原发性肺黏膜相关淋巴组织淋巴瘤1例并文献复习[J]. 临床荟萃, 2023, 38(7): 623-627.
[4]	杜佳宜, 刘丽丽, 何永忠, 田川, 蓝翔, 叶中绿. 儿童急性淋巴细胞白血病化疗期间严重不良事件临床观察[J]. 临床荟萃, 2023, 38(2): 149-154.
[5]	顾佳华, 吴岐. 二元应对干预对中青年乳腺癌患者及其配偶应对能力和婚姻调适的影响[J]. 临床荟萃, 2022, 37(9): 822-826.
[6]	茆蓉, 陶千山, 沈元元, 董毅. 结外NK/T细胞淋巴瘤相关噬血细胞综合征1例[J]. 临床荟萃, 2022, 37(7): 635-639.
[7]	李青, 邓琦. 嵌合抗原受体T细胞治疗复发难治弥漫大B细胞淋巴瘤进展[J]. 临床荟萃, 2022, 37(2): 182-187.
[8]	陆洛, 王飞, 顾伟英. 血管免疫母细胞性T细胞淋巴瘤患者外周血淋巴细胞亚群检测的临床意义[J]. 临床荟萃, 2022, 37(11): 1001-1007.
[9]	尹玲玲, 吴文健, 朱锋. 急性髓系白血病转换为急性淋巴细胞白血病1例并文献复习[J]. 临床荟萃, 2022, 37(11): 1025-1030.
[10]	沈瑞, 雷艳花, 贾昊鹍. 145例弥漫性大B细胞淋巴瘤患者静脉血栓栓塞发生率及危险因素分析[J]. 临床荟萃, 2022, 37(1): 43-45.
[11]	程莉, 黄文荣. 自体造血干细胞移植治疗原发中枢神经系统淋巴瘤[J]. 临床荟萃, 2021, 36(10): 901-904.
[12]	穆孝慧, 艾丽梅. miRNA-141在弥漫大B细胞淋巴瘤中的表达及其与预后的关系[J]. 临床荟萃, 2020, 35(8): 727-731.
[13]	于一娇，杜娟，李薇，蔡艺灵，朱琳，路冬煦，刘丽. 以脊髓病变为首发表现的血管内大B细胞淋巴瘤1例并文献复习[J]. 临床荟萃, 2020, 35(8): 740-744.
[14]	卞乐，艾丽梅. 凋亡调节蛋白XIAP与Omi/HtrA2在弥漫大B细胞淋巴瘤中的表达及其与患者预后的关系[J]. 临床荟萃, 2020, 35(5): 438-444.
[15]	陈先睿，温红，黄建琪，郭碧赟，白海涛，吴谨准. ARID5B基因rsl0821936多态位点与儿童急性淋巴细胞白血病易感关联的系统评价和meta分析[J]. 临床荟萃, 2020, 35(3): 197-205.

二丁酰环磷腺苷钙预防多柔比星化疗后亚急性心脏毒性的临床研究

Clinical study of calcium dibutyryladenosine cyclophosphate in prevention of subacute cardiotoxicity induced by doxorubicin chemotherapy

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价