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婴儿支气管肺炎合并急性心力衰竭的预测因素分析

  

  1. 福建医科大学附属福建省妇幼保健院 儿科, 福建 福州 350001
  • 出版日期:2018-08-05 发布日期:2018-09-10
  • 通讯作者: 通信作者:王世彪,Email: 197783836@qq.com

Prediction factor analysis of infantile bronchopneumonia with acute heart failure

  1. Department of Pediatrics,  Fujian Provincial Maternity and Children Hospital,  Affiliated Hospital of Fujian Medical University,  Fuzhou 350001,  China
  • Online:2018-08-05 Published:2018-09-10
  • Contact: Corresponding author:Wang Shibiao, Email: 197783836@qq.com

摘要: 目的 分析儿科重症监护病房中婴儿支气管肺炎合并急性心力衰竭(AHF)的预测因素。方法 回顾性分析我院381例支气管肺炎婴儿,其中94例发生AHF,287例未发生AHF,比较两组的临床资料,进一步行Logistic回归分析,应用受试者工作特征曲线评价各因素的预测效能,并选取最佳截断(Cutoff)值。结果  两组间营养不良、心律失常、N端B型钠尿肽(NTproBNP)、肌钙蛋白(CTNI)、肌酸激酶同工酶(CKMB)、中性粒/淋巴细胞比、D二聚体差异有统计学意义(P<0.05)。Logistic回归分析表明NTproBNP、CTNI、CKMB和D二聚体是婴儿支气管肺炎合并AHF的独立预测因素,其曲线下面积分别为0.957、0.855、0831、0.823,最佳Cutoff值分别为233.2 pg/ml、0.035 ng/ml、31.15 U/L和1.005 mg/L。结论  NTproBNP、CTNI、CKMB和D二聚体是婴儿支气管肺炎合并AHF的独立预测因素。

关键词: 支气管肺炎, 心力衰竭, 预测, 重症监护病房, 儿科

Abstract: Objective  To analyze the predictors of infantile bronchopneumonia with acute heart failure in pediatric intensive care unit (PICU). Methods  Totally 381 infants with bronchopneumonia in our hospital were retrospectively analysed,  among them, 94 cases had acute heart failure (AHF) and 287 cases had no acute heart failure (nonAHF). The univariate and multivariate logistic regression analysis was conducted,  and the ROC curve was applied to evaluate the predictive efficacy of each factor,  then the optimal cutoff value was selected. Results  There were statistical differences in malnutrition,  arrhythmia,   NTproBNP,  CTNI,  CKMB,  neutrophil to lymphocyte ratio(NLR),  DDimer  between AHF group and nonAHF group (P<0.05). The variables that eventually entered the regression model were NTproBNP,  CTNI,  CKMB and DDimer (P<0.05). The areas under the ROC curves (AUC) of NTproBNP,  CTNI,  CKMB and DDimer were 0.957,  0.855,  0831 and 0.823,  respectively,  and the best cutoff values were 233.2  pg/ml,  0.035  ng/ml,  31.15  U/L and 1.005  mg/L,  respectively. Conclusion  NTproBNP,  CTNI,  CKMB and DDimer are independent predictors of infantile bronchopneumonia with acute heart failure.

Key words: bronchopneumonia, heart failure, prediction, intensive care units; , pediatric