关键词: 螺杆菌, 幽门, 感染, 糖尿病, 2型

Abstract: Objective   To evaluate the association between Helicobacter pylori (H. pylori) infection and type 2 diabetes mellitus (T2DM). Methods  A total of  179 T2DM patients from our hospital were divided into H. pylori positive(n=108) and H. pylori negative(n=71) groups according to 13Curea breath test. At baseline,  we performed blood tests including fasting glucose,  fasting insulin,  glycated haemoglobin A1c (HbA1c) and other biochemical measurements. Results  The prevalence of H. pylori infection was 60.3% in diabetic patients. There was no significant difference between two groups in age,  body mass index,   the duration of diabetes,  SBP,  DBP,  fasting glucose,  HbA1c,  fasting insulin,  fasting C peptide,  ALT,  AST,  TG,  HDLC,  UA,  CRE,  Whether or not insulin used (P>0.05). In T2DM patients,  the males and those who had the family history of diabetes had a higher rate of H. pylori infection (P<0.01). There were significant differences in TC and LDLC (P<0.05). T2DM patients with H. pylori infection had a higher risk of the occurrence of diabetic chronic  complications including,  coronary atherosclerotic cardiopathy，cerebrovascular disease than those without H. pylori infection （P<0.01）. And  the rate of nonalcoholic fatty liver disease was higher in the patients with H. pylori infection (P<0.05). Conclusion  This study showed a higher prevalence of H. pylori infection in diabetic patients,  and H. pylori infection may affect the development of diabetes chronic complications.Proper screening for H. pylori infection and H. pylori eradication therapies in diabetes patients should be recommended.

Key words: Helicobacter pylori；infection； diabetes mellitus, type 2