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贞芪扶正胶囊联合熊去氧胆酸治疗原发性胆汁性胆管炎对甲状腺功能的影响

  

  1. 同济大学附属天佑医院 普外科,上海  200331
  • 出版日期:2020-03-20 发布日期:2020-03-27
  • 通讯作者: 戴德坚,Email:daidejiantianyou@163.com

Efficacy  of  Zhenqi  Fuzheng  Capsule  combined with ursodeoxycholic acid on primary biliary cholangitis and its impact  on thyroid function

  1. Department of General Surgery,  Tianyou Hospital  affiliated to,  Tongji University,  Shanghai 200331, China
  • Online:2020-03-20 Published:2020-03-27
  • Contact: Corresponding author: Dai Dejian,Email: tianyoudaidejian@163.com

摘要: 目的  观察贞芪扶正胶囊联合熊去氧胆酸治疗原发性胆汁性胆管炎(PBC)的疗效,及其对甲状腺功能的影响。方法  在我院诊治的PBC患者70例,随机将患者分为观察组和对照组,每组各35例。对照组予以熊去氧胆酸治疗,观察组在对照组的基础上予以贞芪扶正胶囊治疗。比较两组治疗后的疗效,观察两组治疗前后丙氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、碱性磷酸酶(ALP)、透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原肽(PCⅢ)、基质金属蛋白酶组织抑制因子1(TIMP1)、总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)、总甲状腺素(TT4)和游离甲状腺素(FT4)水平的变化。结果  观察组的总有效率为97.14%,对照组的总有效率为77.14%(P<0.05)。两组治疗后血清ALT、AST、TBIL、ALP、HA、TIMP1、LN和PCⅢ水平均较治疗前明显降低(P<0.01),两组血清TT3、FT3、TT4和FT4水平均较治疗前明显升高(P<0.01),而观察组的降低或者升高水平与对照组比较更加明显(P<0.01)。结论  贞芪扶正胶囊联合熊去氧胆酸治疗原发性胆汁性胆管炎的疗效显著,能够改善机体的纤维化,缓解甲状腺功能低下。

关键词: 中草药, 胆管炎, 甲状腺功能试验, 肝硬化

Abstract: Objective  To observe the efficacy of  Zhenqi Fuzheng Capsule  combined with ursodeoxycholic acid on primary bile cholangitis (PBC) and its impact on the thyroid function. Methods  A total of 70 PBC patients treated in our hospital were randomly divided into observation group and control group,  with 35 cases in each group.The control group was treated with ursodeoxycholic acid,  and the observation group was treated with Zhenqi Fuzheng Capsule combined with ursodeoxycholic acid. The level changes in two groups were observed before and after the treatment in order to compare the efficacy between two groups, including the levels of the alanine aminotransferase (ALT), aspartate aminotransferase (AST),  total bilirubin (TBIL),  alkaline phosphatase (ALP),  hyaluronan acid (HA), laminin(LN),  type Ⅲ  procollagen peptide (PCⅢ),  tissue inhibitor of metalloproteinase 1 (TIMP1),  total triiodothyronine (TT3),  free triiodothyroxine (FT3),  total thyroxine (TT4) and free thyroxine (FT4).Results  The total effective rate was 97.14% in observation group,  and that was 77.14%  in control group (P<0.05). After treatment,  the levels of serum ALT,  AST,   TBIL,  ALP,  HA,  TIMP1,  LN and PCⅢ  in two groups were significantly lower than those before treatment (P<0.01),  and the levels of serumTT3,  FT3,  TT4 and FT4 were significantly higher than those before treatment (P<0.01).The decrease or increase of level in observation group was more obvious than that in control group (P<0.01). Conclusion  Zhenqi Fuzheng Capsule combined with ursodeoxycholic acid has significant effecton PBC,  which can also improvethe fibrosis of the body and relievethe hypothyroidism.

Key words: drus, Chinese herbal; , cholangitis, thyroid function tests, liver cirrhosis