维生素D缺乏与自身免疫性肝炎相关性研究进展

doi:10.3969/j.issn.1004-583X.2021.09.018

摘要/Abstract

摘要：

自身免疫性肝炎是一种病因不明的免疫介导的慢性炎症性肝病,其临床特征为自身抗体阳性、转氨酶升高以及高丙种球蛋白血症,病理表现包括淋巴细胞浸润和界面性肝炎。随着疾病的进展,可发展为肝纤维化、肝硬化、甚至出现急性重症(爆发性)肝炎或隐源性肝癌。维生素D不仅有调节骨代谢和钙稳态作用的经典途径,还有免疫介导、抗氧化、抗纤维化及抗炎作用的非经典途径。维生素D缺乏与自身免疫性肝炎存在一定的相关性。本文主要从维生素D生物作用、维生素D缺乏机制及与维生素D缺乏与AIH相关机制进行综述。

关键词: 肝炎, 自身免疫性, 维生素D缺乏, 肝硬化, 糖皮质激素类

中图分类号:

R575.1

梅胜梅, 周俊英. 维生素D缺乏与自身免疫性肝炎相关性研究进展[J]. 临床荟萃, 2021, 36(9): 856-860.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.09.018

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I9/856

参考文献 36

[1]	Floreani A, Restrepo-Jimenez P, Secchi MF, et al. Etiopathogenesis of autoimmune hepatitis[J]. J Autoimmun, 2018, 95(12):133-143. doi: 10.1016/j.jaut.2018.10.020 URL
[2]	Czaja AJ. Global disparities and their implications in the occurrence and outcome of autoimmune hepatitis[J]. Dig Dis Sci, 2017, 62(9):2277-2292. doi: 10.1007/s10620-017-4675-y URL
[3]	Yamamoto E, Jorgensen TN. Immunological effects of vitamin D and their relations to autoimmunity[J]. J Autoimmun, 2019, 100:7-16. doi: S0896-8411(19)30033-2 pmid: 30853311
[4]	Udomsinprasert W, Jittikoon J. Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies[J]. Biomed Pharmacother, 2019, 109:1351-1360. doi: S0753-3322(18)36703-9 pmid: 30551386
[5]	Jiang X, O'Reilly PF, Aschard H, et al. Genome-wide association study in 79, 366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels[J]. Nat Commun, 2018, 9(1):260. doi: 10.1038/s41467-017-02662-2 pmid: 29343764
[6]	Chen EQ, Shi Y, Tang H. New insight of vitamin D in chronic liver diseases[J]. Hepatobiliary Pancreat Dis Int, 2014, 13(6):580-585. doi: 10.1016/S1499-3872(14)60295-2 URL
[7]	Adorini L. Vitamin D receptor polymorphisms in primary biliary cirrhosis: A functional connection?[J]. J Hepatol, 2009, 50(6):1071-1073. doi: 10.1016/j.jhep.2009.03.005 URL
[8]	Adams JS, Hewison M. Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity[J]. Nat Clin Pract Endocrinol Metab, 2008, 4(2):80-90. doi: 10.1038/ncpendmet0716 pmid: 18212810
[9]	Penna G, Adorini L. 1 Alpha, 25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation[J]. J Immunol, 2000, 164(5):2405-2411. pmid: 10679076
[10]	Sassi F, Tamone C, d'Amelio P. Vitamin D: Nutrient, hormone, and immunomodulator[J]. Nutrients, 2018, 10(11):1656. doi: 10.3390/nu10111656 URL
[11]	Xie Z, Chen J, Zheng C, et al. 1, 25-dihydroxyvitamin D3-induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing T helper type 1 and type 17 cells[J]. Immunology, 2017, 152(3):414-424. doi: 10.1111/imm.2017.152.issue-3 URL
[12]	Luong KV, Nguyen LT. The role of vitamin d in autoimmune hepatitis[J]. J Clin Med Res, 2013, 5(6):407-415.
[13]	Arai T, Atsukawa M, Tsubota A, et al. Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease[J]. Dig Liver Dis, 2019, 51(7):1036-1042. doi: 10.1016/j.dld.2018.12.022 URL
[14]	Reiter FP, Hohenester S, Nagel JM, et al. 1, 25-(OH)(2)-vitamin D(3) prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-/-) model[J]. Biochem Biophys Res Commun, 2015, 459(2):227-233. doi: 10.1016/j.bbrc.2015.02.074 URL
[15]	Ding N, Yu RT, Subramaniam N, et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response[J]. Cell, 2013, 153(3):601-613. doi: 10.1016/j.cell.2013.03.028 URL
[16]	Wahsh E, Abu-Elsaad N, El-Karef A, et al. The vitamin D receptor agonist, calcipotriol, modulates fibrogenic pathways mitigating liver fibrosis in-vivo: An experimental study[J]. Eur J Pharmacol, 2016, 789:362-369. doi: S0014-2999(16)30493-9 pmid: 27477355
[17]	Hu XD, Jiang SL, Liu CH, et al. Preventive effects of 1, 25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression[J]. Acta Pharmacol Sin, 2010, 31(6):703-708. doi: 10.1038/aps.2010.53 URL
[18]	Ebadi M, Bhanji RA, Mazurak VC, et al. Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis[J]. Aliment Pharmacol Ther, 2019, 49(2):173-182. doi: 10.1111/apt.15029 URL
[19]	Zhang Y, Leung DY, Goleva E. Vitamin D enhances glucocorticoid action in human monocytes: Involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14[J]. J Biol Chem, 2013, 288(20):14544-14553. doi: 10.1074/jbc.M112.427054 pmid: 23572530
[20]	Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1[J]. J Immunol, 2012, 188(5):2127-2135. doi: 10.4049/jimmunol.1102412 pmid: 22301548
[21]	Bellan M, Andreoli L, Mele C, et al. Pathophysiological role and therapeutic implications of vitamin D in autoimmunity: Focus on chronic autoimmune diseases[J]. Nutrients, 2020, 12(3):789. doi: 10.3390/nu12030789 URL
[22]	Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab, 2011, 96(7):1911-1930. doi: 10.1210/jc.2011-0385 URL
[23]	Duarte C, Carvalheiro H, Rodrigues AM, et al. Prevalence of vitamin D deficiency and its predictors in the Portuguese population: A nationwide population-based study[J]. Arch Osteoporos, 2020, 15(1):36. doi: 10.1007/s11657-020-0695-x pmid: 32124071
[24]	Lee WS, Jalaludin MY, Wong SY, et al. Vitamin D non-sufficiency is prevalent in children with chronic liver disease in a tropical country[J]. Pediatr Neonatol, 2019, 60(1):12-18. doi: 10.1016/j.pedneo.2018.03.011 URL
[25]	Eliades M, Spyrou E, Agrawal N, et al. Meta-analysis: vitamin D and non-alcoholic fatty liver disease[J]. Aliment Pharmacol Ther, 2013, 38(3):246-254. doi: 10.1111/apt.2013.38.issue-3 URL
[26]	Kitson MT, Roberts SK. D-livering the message: the importance of vitamin D status in chronic liver disease[J]. J Hepatol, 2012, 57(4):897-909. doi: 10.1016/j.jhep.2012.04.033 URL
[27]	Nashold FE, Spach KM, Spanier JA, et al. Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression[J]. J Immunol, 2009, 183(6):3672-3681. doi: 10.4049/jimmunol.0901351 pmid: 19710457
[28]	Czaja AJ, Montano-Loza AJ. Evolving role of vitamin D in immune-mediated disease and its implications in autoimmune hepatitis[J]. Dig Dis Sci, 2019, 64(2):324-344. doi: 10.1007/s10620-018-5351-6 URL
[29]	Vogel A, Strassburg CP, Manns MP. Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis[J]. Hepatology, 2002, 35(1):126-131 doi: 10.1053/jhep.2002.30084 URL
[30]	Fan L, Tu X, Zhu Y, et al. Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese[J]. J Gastroenterol Hepatol, 2005, 20(2):249-255. doi: 10.1111/jgh.2005.20.issue-2 URL
[31]	Jeong MS, Kim JY, Lee HI, et al. Calcitriol may down-regulate mRNA over-expression of Toll-like receptor-2 and -4, LL-37 and proinflammatory cytokines in cultured human keratinocytes[J]. Ann Dermatol, 2014, 26(3):296-302. doi: 10.5021/ad.2014.26.3.296 pmid: 24966627
[32]	Roth CL, Elfers CT, Figlewicz DP, et al. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation[J]. Hepatology, 2012, 55(4):1103-1111. doi: 10.1002/hep.24737 URL
[33]	Tao S, Zhang H, Zhao Q, et al. Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis[J]. Exp Ther Med, 2020, 19(5):3419-3424.
[34]	Paternostro R, Wagner D, Reiberger T, et al. Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis[J]. Wien Klin Wochenschr, 2017, 129(1-2):8-15. doi: 10.1007/s00508-016-1127-1 pmid: 27888359
[35]	Efe C, Kav T, Aydin C, et al. Low serum vitamin D levels are associated with severe histological features and poor response to therapy in patients with autoimmune hepatitis[J]. Dig Dis Sci, 2014, 59(12):3035-3042. doi: 10.1007/s10620-014-3267-3 URL
[36]	Bouillon R. Comparative analysis of nutritional guidelines for vitamin D[J]. Nat Rev Endocrinol, 2017, 13(8):466-479. doi: 10.1038/nrendo.2017.31 pmid: 28387318

维生素D缺乏与自身免疫性肝炎相关性研究进展

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 36

相关文章 15

编辑推荐

Metrics

本文评价

[1]	张晓璐, 李红山. 自身免疫性肝炎发病机制研究进展——聚焦“肠道菌群与免疫系统相互作用”[J]. 临床荟萃, 2024, 39(2): 177-182.
[2]	游琪琪, 霍丽娟. 原发性胆汁性胆管炎-自身免疫性肝炎重叠综合征的诊治进展[J]. 临床荟萃, 2024, 39(1): 84-87.
[3]	何培华, 周幸福, 洪炜鸿, 王利纯, 刘素君, 金玉燕, 曾佳豪, 刘立昌. IgG4相关性肾病4例临床分析[J]. 临床荟萃, 2023, 38(11): 1016-1021.
[4]	叶倩, 凌志, 刘申香, 路国涛, 殷旭东. 糖皮质激素对晚期肿瘤患者免疫疗效影响的Meta分析[J]. 临床荟萃, 2022, 37(7): 591-598.
[5]	林长艺, 宋明辉, 吴培埕. 诊断年龄对风湿性多肌痛临床特征的影响: 68例患者的单中心回顾性队列研究[J]. 临床荟萃, 2022, 37(7): 612-615.
[6]	臧佳佳, 高艳锋, 韩书芝, 平芬. 老年急性嗜酸性粒细胞肺炎1例并文献复习[J]. 临床荟萃, 2022, 37(10): 931-933.
[7]	赵小玲, 郑吉敏, 杜季康. 肠道菌群与自身免疫性肝病的研究进展[J]. 临床荟萃, 2021, 36(6): 574-576.
[8]	王诗梦, 马英骥, 吴颖, 刘晓丹, 王伟. 乙型肝炎病毒感染对肿瘤肝转移影响的Meta分析[J]. 临床荟萃, 2021, 36(5): 389-394.
[9]	王园园, 程宁, 林海燕. 慢性乙型肝炎患者血清sST2与肝功能、血小板水平及Ishak评分的相关性[J]. 临床荟萃, 2021, 36(11): 976-980.
[10]	佟印妮, 黄艳册, 郑吉敏. 肝硬化顽固性腹水的治疗[J]. 临床荟萃, 2021, 36(1): 70-74.
[11]	王晓玲，沈丽贤，李惠文，张亚芹，李瑶，吴书娜. 急性乙型肝炎患者pDCs上CD86表达变化及意义[J]. 临床荟萃, 2020, 35(8): 719-723.
[12]	原慧芳. 丙型肝炎病毒感染者胆囊疾病发生情况及临床分析[J]. 临床荟萃, 2020, 35(7): 620-623.
[13]	刘双，赵东强. 失代偿期肝硬化治疗中存在的几个问题[J]. 临床荟萃, 2020, 35(7): 647-652.
[14]	程明荣，戴德坚. 贞芪扶正胶囊联合熊去氧胆酸治疗原发性胆汁性胆管炎对甲状腺功能的影响[J]. 临床荟萃, 2020, 35(3): 260-263.
[15]	江萍1，王存凯2，王玉珍2. 血清学指标评估乙型肝炎肝纤维化程度及预后的研究进展[J]. 临床荟萃, 2020, 35(10): 947-951.