天麻钩藤饮联合厄贝沙坦治疗原发性高血压的随机对照临床试验

doi:10.3969/j.issn.1004583X.2020.12.007

临床荟萃 ›› 2020, Vol. 35 ›› Issue (12): 1097-1100.doi: 10.3969/j.issn.1004583X.2020.12.007

天麻钩藤饮联合厄贝沙坦治疗原发性高血压的随机对照临床试验

1.广州市天河区天河南街社区卫生服务中心中医科，广州 510620；2.广州中医药大学第一附属医院心血管内科，广州 510405；
3.广州中医药大学第三附属医院内科，广州 510378

出版日期:2020-12-20 发布日期:2020-11-27
通讯作者: 梁玉玲, Email: 2832659013@qq.com

Randomized controlled trial of Tianma Gouteng Decoction and irbesartan in treatment of essential hypertension

1. Department of Traditional Chinese Medicine, Tianhe South Street Community Health Service Center of
Tianhe District, Guangzhou 510620, China; 2. Department of Cardiology, the First Affiliated Hospital
of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;
3. Department of Internal Medicine, the Third Affiliated Hospital of Guangzhou University of
Traditional Chinese Medicine, Guangzhou 510378, China

Online:2020-12-20 Published:2020-11-27
Contact: Corresponding author:Liang Yuling, Email: 2832659013@qq.com

摘要/Abstract

摘要： 目的探讨天麻钩藤饮联合厄贝沙坦在原发性高血压治疗中的临床疗效。方法选取2018年1月至2020年1月我院收治的136例原发性高血压患者，随机将其分为观察组（68例）和对照组（68例），对照组采用厄贝沙坦治疗，观察组给予天麻钩藤饮联合厄贝沙坦治疗，均连续治疗4周，比较两组患者中医症候积分及临床疗效，并分析两组患者治疗前后血压、氧化应激指标及血管内皮损伤标志物水平。结果观察组治疗后的中医症候积分显著低于对照组（P<0.01），且临床总有效率明显高于对照组（P<0.05）。治疗组较对照组治疗后的收缩压和舒张压均降低（P<0.05）。与对照组比较，观察组治疗后血清AOPP和MDA明显降低，而血清SOD明显升高（P<0.05）；血清ET1、ICAM1及vWF明显升高，而血清NO明显降低（P<0.05）。结论天麻钩藤饮联合厄贝沙坦治疗原发性高血压的临床疗效肯定，更有利于减轻血管内皮损伤，促进氧化应激状态的改善。

关键词: 高血压, 中草药, 治疗结果

Abstract: Objective To investigate the clinical efficacy of Tianma Gouteng Decoction combined with irbesartan in the treatment of essential hypertension. Methods A total of 136 patients with essential hypertension admitted to our hospital from January 2018 to January 2020 were selected. They were randomly divided into observation group (68 cases) and control group (68 cases). The control group was treated with irbesartan tablets, and the observation group was treated with Tianma Gouteng Decoction combined with irbesartan tablets. Both groups were continuously treated for four weeks. The clinical efficacy and TCM symptom scores of two groups were analyzed, and the blood pressure, oxidative stress indicators and vascular endothelial injury marker levels of two groups were compared before and after treatment. Results After treatment, the TCM symptom scores of observation group were significantly lower than those of control group (P<0.01). The total clinical effective rate in observation group was higher than that in control group (P<0.05). After the treatment, both systolic blood pressure and diastolic blood pressure in observation group were lower than those in control group (P<0.05). Compared with control group, observation group had lower serum AOPP and MDA, and higher serum SOD (P<0.05). And serum ET1, ICAM1 and vWF were significantly higher in observation group than those in control group, while serum NO in observation group was lower than that in control group(P<0.05). Conclusion Tianma Gouteng Decoction combined with irbesartan tablets in the treatment of essential hypertension is definitely effective, which can reduce vascular endothelial damage and help improve oxidative stress.

Key words: hypertension, drugs, Chinese herbal, treatment outcome

中图分类号:

R544.1

梁玉玲, 李文晞, 古学文. 天麻钩藤饮联合厄贝沙坦治疗原发性高血压的随机对照临床试验[J]. 临床荟萃, 2020, 35(12): 1097-1100.

Liang Yuling, Li Wenxi, Gu Xuewen. Randomized controlled trial of Tianma Gouteng Decoction and irbesartan in treatment of essential hypertension[J]. Clinical Focus, 2020, 35(12): 1097-1100.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004583X.2020.12.007

https://huicui.hebmu.edu.cn/CN/Y2020/V35/I12/1097

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天麻钩藤饮联合厄贝沙坦治疗原发性高血压的随机对照临床试验

Randomized controlled trial of Tianma Gouteng Decoction and irbesartan in treatment of essential hypertension

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