关键词: 动脉硬化, 冠心病, 冠状动脉造影术, 绝经后期, 女性

Abstract: Objective  To investigate the predictive value of atherogenic index of plasma（AIP）  in postmenopausal women with coronary heart disease(CHD). Methods  A retrospective analysis method was used to select 233 postmenopausal women who were with suspected CHD and underwent coronary angiography in our hospital. The patients were divided into CHD group (n=171) and control group (n=62) according to the results of coronary angiography. The differences of AIP between two groups were compared. Binary logistic regression was used to analyze the independent risk factors for postmenopausal women with CHD. And the predictive value of AIP for postmenopausal women with CHD was analyzed. Results  The AIP levels in CHD group were significantly higher than those in control group(P<0.01). Binary Logistic regression analysis showed that high AIP,  low estradiol (E2),  and hypertension were independent risk factors for postmenopausal women with CHD（OR=8.784，P=0.002，95%CI：2.17035.558；OR=0.813，P=0.000，95%CI：0.7640.865；OR=2.151，P=0.037，95%CI：1.0464.422）. The ROC curve analysis showed that the optimal threshold for adjusted AIP to predict CHD was 2.02,  with sensitivity  66.7%  and specificity   64.5%. Conclusion  The high AIP levels and low estradiol level can be independent risk factors for postmenopausal women with CHD. AIP can be used to predict CHD in postmenopausal women. When adjusted AIP is more than 2.02,  there is a risk of  CHD.

Key words: arteriosclerosis, coronary disease, coronary angiography, postmenopause, femininity