血清胆红素、NBR在溃疡性结肠炎病情评估中的价值

doi:10.3969/j.issn.1004-583X.2024.07.004

摘要/Abstract

摘要：

目的分析血清总胆红素(total bilirubin, TBIL)、间接胆红素(indirect bilirubin, IBIL)、直接胆红素(direct bilirubin, DBIL)及中性粒细胞百分比与总胆红素比值(neutrophil-to-total bilirubin ratio, NBR)与溃疡性结肠炎(ulcerative colitis, UC)严重程度及病变范围的相关性。方法回顾性收集2018年6月至2023年6月于山西医科大学第一医院住院治疗的250例活动期UC患者及同期在该院体检的250例健康人为研究对象,收集其临床资料并计算NBR。利用SPSS 26.0软件分析UC与健康人、UC不同严重程度、不同病变范围、不同临床类型间TBIL、IBIL、DBIL及NBR的差异;通过Spearson相关性分析上述指标与血红蛋白(hemoglobin, Hb)、白蛋白(albumin, ALB)、C反应蛋白(C-reactive protein, CRP)、血沉(erythrocyte sedimentation Rate, ESR)及临床Mayo评分间的相关性;通过二元Logistic回归分析TBIL、IBIL、DBIL及NBR与 UC、重度UC、E3型UC的OR值,最终通过绘制受试者工作特征(receiver operating characteristic curve, ROC)曲线确定上述指标对UC、重度UC、E3型UC的预测价值。结果 ①UC患者血清TBIL、IBIL、DBIL水平显著低于健康人,而NBR水平显著升高,差异有统计学意义;②TBIL、IBIL在重度UC、E3型UC患者中显著降低,而NBR则显著升高,差异有统计学意义,DBIL在各亚组间差异无统计学意义;初发型和慢性复发型UC患者各指标差异均无统计学意义;③相关性分析显示,TBIL、IBIL与Hb、ALB水平呈显著正相关,而与ESR、CRP及改良Mayo评分呈显著负相关;NBR则相反;④较低水平的TBIL、IBIL及较高水平的NBR是发生重度UC、E3型UC的危险因素,TBIL≤8.28 μmol/L、IBIL≤6.48 μmol/L、NBR>7.89时发生重度UC的OR值分别为4.119、6.550和4.947,发生E3型UC的OR值分别为2.215、3.087和2.244;⑤ROC曲线表明TBIL、IBIL、NBR对重度UC、E3型UC有轻度预测价值。结论 TBIL、IBIL、NBR与UC患者的严重程度及病变范围有一定的相关性,对重度UC、E3型UC有一定的预测价值。

关键词: 结肠炎, 溃疡性, 胆红素, 中性粒细胞

Abstract:

Objective To analyze the correlation of serum total bilirubin (TBIL), indirect bilirubin (IBIL), direct bilirubin (DBIL), neutrophil-to- total bilirubin ratio (NBR) with ulcerative colitis (UC) with the severity and lesion range. Methods This was a retrospective case-control study involved 250 active UC patients and 250 healthy participants hospitalized in the First Hospital of Shanxi Medical University from June 2018-June 2023. The clinical data of the patients were collected and NBR was calculated. SPSS 26.0 software was performed to analyze the differences in TBIL, IBIL, DBIL, and NBR between healthy individuals and UC with different severity, lesion scope, and clinical types. Spearson correlation analysis was used to analyze the correlation between the above indicators with hemoglobin (Hb), albumin (ALB), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and clinical Mayo scores. The binary logistic regression analysis were performed to assess the odds ratio (OR) values of TBIL, IBIL, DBIL, and NBR with UC, severe UC, and E3 type UC. Finally, the predictive value of the above indicators for UC, severe UC, and E3 type UC was determined by plotting receiver operating characteristic (ROC) curves. Results The serum levels of TBIL, IBIL, and DBIL in UC patients were significantly lower than those in healthy individuals, while the levels of NBR were significantly increased. TBIL and IBIL were significantly reduced in patients with severe UC and E3 type UC, while NBR was significantly increased. There was no significant difference in DBIL among different subgroups. There was no statistically significant difference in various indicators between initial type and chronic recurrent type in UC patients. Correlation analysis showed that TBIL, IBIL were significantly positively correlated with Hb and ALB levels, significantly negatively correlated with ESR, CRP, and modified Mayo scores, but NBR was the opposite. Low levels of TBIL, IBIL and high levels of NBR were risk factors for severe UC and E3 type UC. When TBIL≤8.28 μmol/L, IBIL≤6.48 μmol/L and NBR>7.89, the OR values for severe UC were 4.119, 6.550 and 4.947, respectively, and the OR values for E3 type UC were 2.215, 3.087 and 2.244, respectively. ROC curve showed that TBIL, IBIL and NBR had mild predictive value for severe UC and E3 type UC. Conclusion TBIL, IBIL and NBR are correlated with the severity and lesion range of UC, and there is certain predictive value for severe UC and E3 type UC.

Key words: colitis, ulcerative, bilirubin, neutrophils

中图分类号:

R574.62

陈晓天, 霍丽娟. 血清胆红素、NBR在溃疡性结肠炎病情评估中的价值[J]. 临床荟萃, 2024, 39(7): 603-611.

Chen Xiaotian, Huo Lijuan. Predictive value of serum total bilirubin, neutrophil-to-total bilirubin ratio in evaluating the condition of ulcerative colitis[J]. Clinical Focus, 2024, 39(7): 603-611.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2024.07.004

https://huicui.hebmu.edu.cn/CN/Y2024/V39/I7/603

图/表 14

表1 UC组与健康对照组临床资料比较

Tab.1 Clinical data between UC group and healthy control group

组别	例数	年龄 (岁)	性别[例(%)]		TBIL (μmol/L)	IBILC (μmol/L)	DBIL (μmol/L)	NEUT%	NBR
组别	例数	年龄 (岁)	男	女	TBIL (μmol/L)	IBILC (μmol/L)	DBIL (μmol/L)	NEUT%	NBR
UC组	250	47.10±14.57	149(59.6)	101(40.4)	11.53±4.56	9.15±3.87	2.36±1.16	61.82±11.23	5.31±5.42
健康对照组	250	50.00±13.76	155(62.0)	95(38.0)	14.73±4.94	11.99±4.17	2.79±1.76	55.27±8.42	5.13±1.83
统计值		$t$ =1.560	χ²=0.302		$t$ =-7.543	$t$ =-7.899	$t$ =-3.178	$t$ =7.375	$t$ =8.947
P值		0.121	0.583		<0.01	<0.01	0.002	<0.01	<0.001

表1 UC组与健康对照组临床资料比较

Tab.1 Clinical data between UC group and healthy control group

组别	例数	年龄 (岁)	性别[例(%)]		TBIL (μmol/L)	IBILC (μmol/L)	DBIL (μmol/L)	NEUT%	NBR
组别	例数	年龄 (岁)	男	女	TBIL (μmol/L)	IBILC (μmol/L)	DBIL (μmol/L)	NEUT%	NBR
UC组	250	47.10±14.57	149(59.6)	101(40.4)	11.53±4.56	9.15±3.87	2.36±1.16	61.82±11.23	5.31±5.42
健康对照组	250	50.00±13.76	155(62.0)	95(38.0)	14.73±4.94	11.99±4.17	2.79±1.76	55.27±8.42	5.13±1.83
统计值		$t$ =1.560	χ²=0.302		$t$ =-7.543	$t$ =-7.899	$t$ =-3.178	$t$ =7.375	$t$ =8.947
P值		0.121	0.583		<0.01	<0.01	0.002	<0.01	<0.001

表2 不同严重程度、不同病变范围及不同临床类型的UC临床各参数比较( x -±s)

Tab.2 Clinical parameters in UC with different severity levels, lesion ranges, and clinical types( x -±s)

组别	例数	TBIL(μmol/L)	IBIL(μmol/L)	DBIL(μmol/L)	NEUT%	NBR
轻度	55	13.10±4.50	10.74±3.96	2.34±0.76	57.90±9.87	5.04±2.57
中度	119	11.62±4.51	9.41±3.84	2.22±0.92	61.40±10.59	6.11±2.72
重度	76	10.25±4.34	7.69±3.29	2.60±1.63	65.31±12.16	7.48±3.31
统计值		$F$ =6.570	$F$ =11.998	$F$ =2.606	$F$ =7.475	$F$ =11.839
P值		0.002	<0.01	0.076	0.001	0.001
E1	39	13.09±4.74	10.65±4.27	2.43±0.71	57.84±8.47	5.11±2.33
E2	73	11.87±4.73	9.66±3.99	2.21±0.89	61.60±11.09	6.23±3.39
E3	138	10.91±4.31	8.46±3.54	2.42±1.37	63.06±11.77	6.66±12.88
统计值		$F$ =3.834	$F$ =6.020	$F$ =0.853	$F$ =3.377	$F$ =4.223
P值		0.023	0.003	0.427	0.036	0.016
初发型	67	11.40±5.14	8.97±4.36	2.38±1.20	62.57±11.25	6.51±3.08
慢性复发型	183	11.58±4.34	9.22±3.69	2.36±1.15	61.54±11.23	6.22±2.98
统计值		$F$ =-0.271	$F$ =-0.446	$F$ =0.119	$F$ =0.637	$F$ =0.679
P值		0.787	0.656	0.905	0.525	0.498

表2 不同严重程度、不同病变范围及不同临床类型的UC临床各参数比较( x -±s)

Tab.2 Clinical parameters in UC with different severity levels, lesion ranges, and clinical types( x -±s)

组别	例数	TBIL(μmol/L)	IBIL(μmol/L)	DBIL(μmol/L)	NEUT%	NBR
轻度	55	13.10±4.50	10.74±3.96	2.34±0.76	57.90±9.87	5.04±2.57
中度	119	11.62±4.51	9.41±3.84	2.22±0.92	61.40±10.59	6.11±2.72
重度	76	10.25±4.34	7.69±3.29	2.60±1.63	65.31±12.16	7.48±3.31
统计值		$F$ =6.570	$F$ =11.998	$F$ =2.606	$F$ =7.475	$F$ =11.839
P值		0.002	<0.01	0.076	0.001	0.001
E1	39	13.09±4.74	10.65±4.27	2.43±0.71	57.84±8.47	5.11±2.33
E2	73	11.87±4.73	9.66±3.99	2.21±0.89	61.60±11.09	6.23±3.39
E3	138	10.91±4.31	8.46±3.54	2.42±1.37	63.06±11.77	6.66±12.88
统计值		$F$ =3.834	$F$ =6.020	$F$ =0.853	$F$ =3.377	$F$ =4.223
P值		0.023	0.003	0.427	0.036	0.016
初发型	67	11.40±5.14	8.97±4.36	2.38±1.20	62.57±11.25	6.51±3.08
慢性复发型	183	11.58±4.34	9.22±3.69	2.36±1.15	61.54±11.23	6.22±2.98
统计值		$F$ =-0.271	$F$ =-0.446	$F$ =0.119	$F$ =0.637	$F$ =0.679
P值		0.787	0.656	0.905	0.525	0.498

表3 不同严重程度UC患者间常用指标的比较( x -±s)

Tab.3 Commonly used indicators among patients with UC of different severity levels( x -±s)

组别	例数	Hb(g/L)	ALB(g/L)	ESR(mm/h)	CRP(mg/L)	改良Mayo评分(分)
轻度	55	130.96±10.93	39.81±4.52	12.67±16.10	9.83±21.67	4.96±1.39
中度	119	125.08±22.55	37.79±4.65	22.69±20.91	21.23±33.26	7.90±1.33
重度	76	105.45±31.31	31.34±6.53	42.41±31.64	46.08±41.61	10.46±1.23
统计值		$F$ =20.231	$F$ =50.610	$F$ =27.638	$F$ =20.628	$F$ =280.936
P值		<0.01	<0.01	<0.01	<0.01	<0.01

表3 不同严重程度UC患者间常用指标的比较( x -±s)

Tab.3 Commonly used indicators among patients with UC of different severity levels( x -±s)

组别	例数	Hb(g/L)	ALB(g/L)	ESR(mm/h)	CRP(mg/L)	改良Mayo评分(分)
轻度	55	130.96±10.93	39.81±4.52	12.67±16.10	9.83±21.67	4.96±1.39
中度	119	125.08±22.55	37.79±4.65	22.69±20.91	21.23±33.26	7.90±1.33
重度	76	105.45±31.31	31.34±6.53	42.41±31.64	46.08±41.61	10.46±1.23
统计值		$F$ =20.231	$F$ =50.610	$F$ =27.638	$F$ =20.628	$F$ =280.936
P值		<0.01	<0.01	<0.01	<0.01	<0.01

表4 TBIL、IBIL、NBR与上述指标的相关性

Tab.4 Correlation between TBIL, IBIL and NBR with the above indicators

因变量	TBIL		IBIL		NEUT%		NBR
因变量	$r$ 值	P值	$r$ 值	P值	$r$ 值	P值	$r$ 值	P值
Hb	0.368	<0.01	0.424	<0.01	-0.105	0.097	-0.337	<0.01
ALB	0.303	<0.01	0.386	<0.01	-0.263	<0.01	-0.406	<0.01
ESR	-0.202	<0.01	-0.314	<0.01	0.271	<0.01	0.358	<0.01
CRP	-0.275	<0.01	-0.313	<0.01	0.402	<0.01	0.430	<0.01
改良Mayo评分	-0.277	<0.01	-0.342	<0.01	0.196	<0.01	0.301	<0.01

表4 TBIL、IBIL、NBR与上述指标的相关性

Tab.4 Correlation between TBIL, IBIL and NBR with the above indicators

因变量	TBIL		IBIL		NEUT%		NBR
因变量	$r$ 值	P值	$r$ 值	P值	$r$ 值	P值	$r$ 值	P值
Hb	0.368	<0.01	0.424	<0.01	-0.105	0.097	-0.337	<0.01
ALB	0.303	<0.01	0.386	<0.01	-0.263	<0.01	-0.406	<0.01
ESR	-0.202	<0.01	-0.314	<0.01	0.271	<0.01	0.358	<0.01
CRP	-0.275	<0.01	-0.313	<0.01	0.402	<0.01	0.430	<0.01
改良Mayo评分	-0.277	<0.01	-0.342	<0.01	0.196	<0.01	0.301	<0.01

表5 UC发病危险因素的二元logistic回归分析

Tab.5 Binary logistic regression analysis for UC risk factors

因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	95% $C I$
因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	下限	上限
TBIL	-0.146	0.022	45.706	<0.01	0.0864	0.828	0.901
IBIL	-0.182	0.026	49.075	<0.01	0.833	0.792	0.877
DBIL	-0.273	0.084	10.446	0.001	0.761	0.645	0.898
NEUT%	0.066	0.010	44.921	<0.01	1.069	1.048	1.090
NBR	0.385	0.046	70.251	<0.01	1.469	1.343	1.608

表5 UC发病危险因素的二元logistic回归分析

Tab.5 Binary logistic regression analysis for UC risk factors

因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	95% $C I$
因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	下限	上限
TBIL	-0.146	0.022	45.706	<0.01	0.0864	0.828	0.901
IBIL	-0.182	0.026	49.075	<0.01	0.833	0.792	0.877
DBIL	-0.273	0.084	10.446	0.001	0.761	0.645	0.898
NEUT%	0.066	0.010	44.921	<0.01	1.069	1.048	1.090
NBR	0.385	0.046	70.251	<0.01	1.469	1.343	1.608

表6 TBIL、IBIL、DBIL、NEUT%及NBR水平与UC发病风险的关系

Tab.6 Correlation between TBIL, IBIL, DBIL and NEUT% with NBR levels with UC risk

参数	组别	校正后 $O R$ 值	95% $C I$		P值
参数	组别	校正后 $O R$ 值	下限	上限	P值
TBIL(μmol/L)	≤9.50	5.274	2.911	9.552	0.000
	9.51~12.30	2.451	1.430	4.203	0.001
	12.31~16.20	0.978	0.556	1.719	0.978
	>16.20	参考			-
IBIL(μmol/L)	≤7.53	6.169	3.365	11.310	0.000
	7.54~9.9	2.123	1.242	3.627	0.006
	9.91~12.90	1.068	0.610	1.872	0.817
	>12.90	参考			-
DBIL(μmol/L)	≤1.70	2.581	1.476	4.516	0.001
	1.71~2.30	1.748	1.027	2.974	0.040
	2.31~3.0	0.945	0.540	1.656	0.845
	>3.0	参考			-
NEUT%	≤51.03	参考			-
	51.04~57.55	1.055	0.610	1.826	0.847
	57.56~66.08	1.888	1.096	3.251	0.022
	>66.08	4.872	2.720	8.728	0.000
NBR	≤4.22	参考			-
	4.23~5.65	2.183	1.239	3.847	0.007
	5.66~7.83	2.672	1.526	4.680	0.001
	>7.83	14.928	7.582	29.390	0.000

表6 TBIL、IBIL、DBIL、NEUT%及NBR水平与UC发病风险的关系

Tab.6 Correlation between TBIL, IBIL, DBIL and NEUT% with NBR levels with UC risk

参数	组别	校正后 $O R$ 值	95% $C I$		P值
参数	组别	校正后 $O R$ 值	下限	上限	P值
TBIL(μmol/L)	≤9.50	5.274	2.911	9.552	0.000
	9.51~12.30	2.451	1.430	4.203	0.001
	12.31~16.20	0.978	0.556	1.719	0.978
	>16.20	参考			-
IBIL(μmol/L)	≤7.53	6.169	3.365	11.310	0.000
	7.54~9.9	2.123	1.242	3.627	0.006
	9.91~12.90	1.068	0.610	1.872	0.817
	>12.90	参考			-
DBIL(μmol/L)	≤1.70	2.581	1.476	4.516	0.001
	1.71~2.30	1.748	1.027	2.974	0.040
	2.31~3.0	0.945	0.540	1.656	0.845
	>3.0	参考			-
NEUT%	≤51.03	参考			-
	51.04~57.55	1.055	0.610	1.826	0.847
	57.56~66.08	1.888	1.096	3.251	0.022
	>66.08	4.872	2.720	8.728	0.000
NBR	≤4.22	参考			-
	4.23~5.65	2.183	1.239	3.847	0.007
	5.66~7.83	2.672	1.526	4.680	0.001
	>7.83	14.928	7.582	29.390	0.000

表7 TBIL、IBIL、NEUT%及NBR与重度UC、E3型UC发生风险的二元logistic回归分析

Tab.7 Binary logistic regression analysis of TBIL, IBIL, NEUT% and NBR with the risk of severe UC and E3 type UC

	因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	95% $C I$
	因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	下限	上限
重度UC	TBIL	-0.100	0.035	8.272	0.004	0.905	0.845	0.969
	IBIL	-0.184	0.046	16.289	<0.01	0.832	0.761	0.910
	NEUT%	0.042	0.013	10.157	0.001	1.042	1.016	1.069
	NBR	0.188	0.049	14.866	<0.01	1.207	1.097	1.329
E3型UC	TBIL	-0.068	0.029	5.556	0.018	0.934	0.883	0.989
	IBIL	-0.107	0.035	9.494	0.002	0.898	0.839	0.962
	NEUT%	0.022	0.012	3.742	0.053	1.023	1.000	1.046
	NBR	0.098	0.046	4.559	0.033	1.103	1.008	1.207

表7 TBIL、IBIL、NEUT%及NBR与重度UC、E3型UC发生风险的二元logistic回归分析

Tab.7 Binary logistic regression analysis of TBIL, IBIL, NEUT% and NBR with the risk of severe UC and E3 type UC

	因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	95% $C I$
	因素	回归系数	标准误	Wald χ²值	P值	$O R$ 值	下限	上限
重度UC	TBIL	-0.100	0.035	8.272	0.004	0.905	0.845	0.969
	IBIL	-0.184	0.046	16.289	<0.01	0.832	0.761	0.910
	NEUT%	0.042	0.013	10.157	0.001	1.042	1.016	1.069
	NBR	0.188	0.049	14.866	<0.01	1.207	1.097	1.329
E3型UC	TBIL	-0.068	0.029	5.556	0.018	0.934	0.883	0.989
	IBIL	-0.107	0.035	9.494	0.002	0.898	0.839	0.962
	NEUT%	0.022	0.012	3.742	0.053	1.023	1.000	1.046
	NBR	0.098	0.046	4.559	0.033	1.103	1.008	1.207

表8 TBIL、IBIL、NEUT%及NBR与重度UC、E3型UC发病风险的关系

Tab.8 Correlation between TBIL, IBIL, NEUT% and NBR with the risk of severe UC and E3 type UC

	组别	重度				E3
		校正后OR	95% $C I$		P值	校正后OR	95% $C I$		P值
		校正后OR	下限	上限	P值	校正后OR	下限	上限	P值
TBIL(μmol/L)	≤8.28	4.119	1.747	9.712	0.001	2.215	1.045	4.695	0.038
	8.29~10.70	2.163	0.924	5.062	0.075	2.329	1.120	4.844	0.024
	10.71~13.73	1.669	0.679	4.103	0.264	1.265	0.603	2.654	0.534
	>13.73	参考			-	-			-
IBIL(μmol/L)	≤6.48	6.550	2.636	16.274	0.000	3.087	1.437	6.633	0.004
	6.49~8.45	2.781	1.108	6.979	0.029	2.910	1.370	6.183	0.005
	8.46~11.20	2.198	0.852	5.672	0.104	1.527	0.729	3.196	0.262
	>11.20	参考			-	-			-
NEUT%	≤54.30	参考			-	-			-
	54.31~62.30	0.835	0.343	2.030	0.690	-			-
	62.31~69.28	1.496	0.650	3.444	0.344	-			-
	>69.28	2.863	1.255	6.534	0.012	-			-
NBR	≤4.22	参考			-	-			-
	4.23~5.60	1.961	0.786	4.888	0.149	1.259	0.611	2.594	0.149
	5.61~7.89	2.679	1.099	6.528	0.030	1.969	0.947	4.093	0.030
	>7.89	4.947	2.060	11.876	0.000	2.244	1.056	4.766	0.000

表8 TBIL、IBIL、NEUT%及NBR与重度UC、E3型UC发病风险的关系

Tab.8 Correlation between TBIL, IBIL, NEUT% and NBR with the risk of severe UC and E3 type UC

	组别	重度				E3
		校正后OR	95% $C I$		P值	校正后OR	95% $C I$		P值
		校正后OR	下限	上限	P值	校正后OR	下限	上限	P值
TBIL(μmol/L)	≤8.28	4.119	1.747	9.712	0.001	2.215	1.045	4.695	0.038
	8.29~10.70	2.163	0.924	5.062	0.075	2.329	1.120	4.844	0.024
	10.71~13.73	1.669	0.679	4.103	0.264	1.265	0.603	2.654	0.534
	>13.73	参考			-	-			-
IBIL(μmol/L)	≤6.48	6.550	2.636	16.274	0.000	3.087	1.437	6.633	0.004
	6.49~8.45	2.781	1.108	6.979	0.029	2.910	1.370	6.183	0.005
	8.46~11.20	2.198	0.852	5.672	0.104	1.527	0.729	3.196	0.262
	>11.20	参考			-	-			-
NEUT%	≤54.30	参考			-	-			-
	54.31~62.30	0.835	0.343	2.030	0.690	-			-
	62.31~69.28	1.496	0.650	3.444	0.344	-			-
	>69.28	2.863	1.255	6.534	0.012	-			-
NBR	≤4.22	参考			-	-			-
	4.23~5.60	1.961	0.786	4.888	0.149	1.259	0.611	2.594	0.149
	5.61~7.89	2.679	1.099	6.528	0.030	1.969	0.947	4.093	0.030
	>7.89	4.947	2.060	11.876	0.000	2.244	1.056	4.766	0.000

图1 TBIL、IBIL、DBIL、NEUT%、NBR对UC预测价值的ROC曲线

Fig.1 ROC curves of TBIL, IBIL, DBIL, NEUT% and NBR for predicting UC value

表9 TBIL、IBIL、DBIL、NEUT%、NBR对UC的预测价值

Tab.9 Predictive value of TBIL, IBIL, DBIL, NEUT% and NBR for UC

指标	AUC	标准误	P值	95% $C I$		敏感度	特异度	约登指数	界值
指标	AUC	标准误	P值	下限	上限	敏感度	特异度	约登指数	界值
TBIL	0.700	0.023	<0.01	0.654	0.746	0.648	0.688	0.336	12.05
IBIL	0.707	0.023	<0.01	0.662	0.752	0.628	0.708	0.336	9.65
DBIL	0.619	0.025	<0.01	0.570	0.669	0.584	0.628	0.212	2.25
NEUT%	0.681	0.024	<0.01	0.634	0.728	0.532	0.784	0.316	61.8
NBR	0.744	0.022	<0.01	0.701	0.787	0.496	0.896	0.392	7.28

表9 TBIL、IBIL、DBIL、NEUT%、NBR对UC的预测价值

Tab.9 Predictive value of TBIL, IBIL, DBIL, NEUT% and NBR for UC

指标	AUC	标准误	P值	95% $C I$		敏感度	特异度	约登指数	界值
指标	AUC	标准误	P值	下限	上限	敏感度	特异度	约登指数	界值
TBIL	0.700	0.023	<0.01	0.654	0.746	0.648	0.688	0.336	12.05
IBIL	0.707	0.023	<0.01	0.662	0.752	0.628	0.708	0.336	9.65
DBIL	0.619	0.025	<0.01	0.570	0.669	0.584	0.628	0.212	2.25
NEUT%	0.681	0.024	<0.01	0.634	0.728	0.532	0.784	0.316	61.8
NBR	0.744	0.022	<0.01	0.701	0.787	0.496	0.896	0.392	7.28

图2 TBIL、IBIL、NEUT%、NBR对重度UC预测价值的ROC曲线

Fig.2 ROC curves of TBIL, IBIL, NEUT% and NBR for the predictive value of severe UC

表10 TBIL、IBIL、NEUT%、NBR对重度UC的预测价值

Tab.10 Predictive value of TBIL, IBIL, NEUT% and NBR for severe UC

指标	AUC	标准误	P值	95% $C I$		敏感度	特异度	约登指数	界值
指标	AUC	标准误	P值	下限	上限	敏感度	特异度	约登指数	界值
TBIL	0.632	0.029	0.001	0.555	0.709	0.592	0.632	0.224	10.05
IBIL	0.680	0.037	<0.001	0.608	0.753	0.671	0.621	0.292	8.15
NEUT%	0.634	0.040	0.001	0.555	0.712	0.737	0.511	0.248	60.45
NBR	0.668	0.038	<0.001	0.594	0.741	0.763	0.511	0.275	5.15

表10 TBIL、IBIL、NEUT%、NBR对重度UC的预测价值

Tab.10 Predictive value of TBIL, IBIL, NEUT% and NBR for severe UC

指标	AUC	标准误	P值	95% $C I$		敏感度	特异度	约登指数	界值
指标	AUC	标准误	P值	下限	上限	敏感度	特异度	约登指数	界值
TBIL	0.632	0.029	0.001	0.555	0.709	0.592	0.632	0.224	10.05
IBIL	0.680	0.037	<0.001	0.608	0.753	0.671	0.621	0.292	8.15
NEUT%	0.634	0.040	0.001	0.555	0.712	0.737	0.511	0.248	60.45
NBR	0.668	0.038	<0.001	0.594	0.741	0.763	0.511	0.275	5.15

图3 TBIL、IBIL、NBR对E3型UC预测价值的ROC曲线

Fig.3 ROC curves of TBIL, IBIL and NBR for the predictive value of E3 type UC

表11 TBIL、IBIL、NBR对E3型UC的预测价值

Tab.11 Predictive value of TBIL, IBIL and NBR for E3 type UC

指标	AUC	标准误	P值	95% $C I$		敏感度	特异度	约登指数	界值
指标	AUC	标准误	P值	下限	上限	敏感度	特异度	约登指数	界值
TBIL	0.593	0.036	0.011	0.523	0.664	0.565	0.643	0.208	10.35
IBIL	0.617	0.036	0.002	0.547	0.687	0.580	0.652	0.231	8.25
NBR	0.608	0.036	0.003	0.538	0.679	0.652	0.563	0.215	5.21

表11 TBIL、IBIL、NBR对E3型UC的预测价值

Tab.11 Predictive value of TBIL, IBIL and NBR for E3 type UC

指标	AUC	标准误	P值	95% $C I$		敏感度	特异度	约登指数	界值
指标	AUC	标准误	P值	下限	上限	敏感度	特异度	约登指数	界值
TBIL	0.593	0.036	0.011	0.523	0.664	0.565	0.643	0.208	10.35
IBIL	0.617	0.036	0.002	0.547	0.687	0.580	0.652	0.231	8.25
NBR	0.608	0.036	0.003	0.538	0.679	0.652	0.563	0.215	5.21

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