关键词: 紫癜, 过敏性；肾小球肾炎；趋化因子CCL2

Abstract: ObjectiveTo investigate urinary monocyte chemoattractant protein1 (MCP1) level and clinical significance in HenochSchonlein purpura（HSP） children with nephritis. MethodsAccording to whether combined with HenochSchonlein purpura  nephritis (HSPN)， 153  HSP children  were grouped into HSP group (n=72) and HSPN group (n=81). According to total urine protein in 24 hours(TUPr)，HSPN group was further divided into mild proteinuria group(n=28)(TUPr＜25 mg/kg)，moderate proteinuria group (n=32)(25 mg/kg≤TUPr＜50 mg/kg)  and severe proteinuria group (n=21)(TUPr≥50 mg/kg). Meanwhile， 45 healthy children were enrolled as control group.  The level of urinary MCP1 was measured by enzymelinked immunosorbent assay. At the same time，the levels of serum creatinine， blood urea nitrogen(BUN)， urinary α1micro globulin(α1MG)， microalbumin(mAlb)， immuno globulin G (IgG)， transferrin (TRF) and TUPr were detected for their associations with MCP1.ResultsUrinary MCP1 was significantly higher in HSPN group in comparison with HSP group and control  group(P＜0.05)， but no significant difference was found between HSP group and control group(P＞0.05).With the increase of  TUPr， urine MCP1  concentration in HSPN groups showed an obviously increasing trend. Urinary MCP1 correlated positively with urinary  α1MG， mAlb， IgG， TRF and TUPr  in HSPN， whereas it had  no significant correlation with serum BUN and creatinine.ConclusionMCP1 increase in children with HSPN was correlated with proteinuria. And MCP1 played an important role in pathological process of HSP lesion.

Key words: purpura, HenochSchonlein;glomerulonephritis, cytokine CCL2