关键词: 帕金森病, 认知障碍, 动态血压

Abstract: Objective  Patients with Parkinson's disease (PD) are commonly accompanied by abnormal dynamic blood pressure (ABP) and cognitive impairment  and the exact mechanism of the cognitive impairment is unclear. We aim to investigate  the relationship between ambulatory blood pressure (ABP) and cognitive function in PD patients.Methods  24 h ABP monitoring were taken in 60 cases of patients with idiopathic PD,  compared to 40 healthy controls with matched age and gender.24 h ABP monitoring and MoCA scores  were performed in the two groups. The change of the two groups of ABP were compared and the influence of ABP change in cognitive function was evaluated.Results  The incidence of nondipping blood pressure in PD group was significantly higher than that in control group (P=0.028).Night mean blood pressure (nMBP) of PD group increased significantly compared with control group (P=0.049).The decrease of mean arterial blood pressure in PD group at night (MABP%) was significantly lower than that in the control group (P=0.022).MoCA score of PD group was significantly lower than that of control group (P=0.024).MABP%,  UPDRS,  age and education years in PD group had significant influence on MoCA score (P=0.04,  0.012,  0.015,  0.020),  while education years and age in control group had significant influence on MoCA score (P=0.010 and 0.035,  respectively). Conclusion  MABP% is an independent risk factor for PD patient’s   cognitive decline rather than normal people.

Key words: parkinson , disease, cognition disorders, ambulatory blood pressure