超声评价抗肿瘤坏死因子α制剂对强直性脊柱炎跟腱附着点炎的疗效

doi:10.3969/j.issn.1004-583X.2018.05.017

临床荟萃

超声评价抗肿瘤坏死因子α制剂对强直性脊柱炎跟腱附着点炎的疗效

河北医科大学第三医院免疫风湿科，河北石家庄 050051

出版日期:2018-05-05 发布日期:2018-05-29
通讯作者: 通信作者：陈海英，Email：xiejanly@hotmail.com

Efficacy of anti tumor necrosis factor α preparation in achilles tendon enthesitis

Department of Rheumatology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Online:2018-05-05 Published:2018-05-29
Contact: Corresponding author: Chen Haiying, Email: xiejanly@hotmail.com

摘要/Abstract

摘要： 目的通过超声评价抗肿瘤坏死因子α（TNFα）制剂对于强直性脊柱炎（ankylosing spodylitis，AS）患者跟腱附着点炎的疗效。方法对比32例应用抗TNFα制剂的治疗组患者与29例对照组患者的跟腱附着点超声影像及红细胞沉降量（erythrocyte sedimentation rate，ESR）、C反应蛋白（Creactive protein，CRP）等炎性指标的变化。结果与对照组比较，应用抗TNFα制剂的AS患者的跟腱附着点处的超声评分及临床评分显著下降（P<0.01）；ESR及CRP的变化差值显著高于对照组(均P<0.01)。结论抗TNFα制剂可显著改善AS患者跟腱附着点处的炎症程度，并通过超声检查得以印证。

关键词: 脊柱炎, 强直性, 跟腱, 超声检查, 肿瘤坏死因子&alpha

Abstract: Objective To explore the value of anti tumor necrosis factor α (TNFα) preparation in achilles tendon enthesitis in ankylosing spodylitis(AS) by ultrasonics. Methods We chose 32 AS patients who received anti TNFα preparation as experiment group and 29 AS patients who got conventional therapy as control group. The ultrasound images, erythrocyte sedimentation rate(ESR) and C reactive protein(CRP) were compared after six weeks of treatment between two groups. Results Compared with the control group, the ultrasound scores and clinic scores of achilles tendon enthesitis in experiment group witnessed significant reduction（both P<0.01). The changes of ESR and CRP in experiment group were more significant than those in control group(both P<0.01). Conclusion Anti TNFα preparation can improve the achilles tendon enthesitis in AS patients, which has been proved by ultrasonics.

Key words: spondylitis ankylosing, achilles tendon, ultrasonography, tumor neerosis factoralpha

谢建丽，陈海英，王俊祥，张颖，徐锦荣. 超声评价抗肿瘤坏死因子α制剂对强直性脊柱炎跟腱附着点炎的疗效[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2018.05.017.

Xie Jianli, Chen Haiying, Wang Junxiang, Zhang Ying, Xu Jinrong. Efficacy of anti tumor necrosis factor α preparation in achilles tendon enthesitis[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2018.05.017.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2018.05.017

https://huicui.hebmu.edu.cn/CN/Y2018/V33/I5/431

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超声评价抗肿瘤坏死因子α制剂对强直性脊柱炎跟腱附着点炎的疗效

Efficacy of anti tumor necrosis factor α preparation in achilles tendon enthesitis

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