比较中性粒细胞与淋巴细胞比值与传统炎性指标对2型糖尿病患者增强CT后造影剂肾病的预测价值

doi:10.3969/j.issn.1004-583X.2019.12.008

临床荟萃

比较中性粒细胞与淋巴细胞比值与传统炎性指标对2型糖尿病患者增强CT后造影剂肾病的预测价值

1.大连市中心医院内分泌科，辽宁大连 116033； 2. 大连市第三人民医院心内一科，辽宁大连 116033

出版日期:2019-12-20 发布日期:2020-01-19
通讯作者: 高政南, Email: gxl6406@sina.com

Comparison of neutrophil to lymphocyte ratio and traditional inflammatory markers in predicting for contrastinduced nephropathy in patients with type 2 diabetes mellitus

1.Department of Endocrinology, Dalian Municipal Central Hospital, Dalian 116033, China;
2. Department of Cardiology, Dalian Third People's Hospital, Dalian 116033, China

Online:2019-12-20 Published:2020-01-19
Contact: Correspondiong author: Gao Zhengnan, Email: gxl6406@sina.com

摘要/Abstract

摘要： 目的比较中性粒细胞与淋巴细胞比值（NLR）与尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）等传统炎性指标对糖尿病患者行增强CT后造影剂肾病（CIN）的预测价值。方法选取行增强CT的2型糖尿病患者88例，检测行增强CT前及CT后6小时、24小时及48小时的血常规、血肌酐（SCr）、胱抑素（CysC）、高敏C反应蛋白（hsCRP）、尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）。根据尿MA/Cr结果，分为糖尿病肾病组及非糖尿病肾病组。根据CIN诊断标准，分为CIN组及正常组。分别比较两组间中性粒细胞淋巴细胞比值（NLR）与NGAL等指标的相关性，比较NLR与其它指标的预测价值。结果所有患者CT后发生CIN的共有6例，发生率为6.8％，均发生在糖尿病肾病患者中。有糖尿病肾病组NLR、尿NGAL较非糖尿病组升高（P＜0.05）。Pearson相关分析显示NLR与SCr显著正相关（r=0.785，P=0.012），NLR与尿NGAL亦明显正相关（r=0.764，P=0.018）。通过Logistics回归提示校正各种相关因素后，NLR仍是CIN发病的危险因素（P＜0.05）。结论糖尿病肾病患者更易发生造影剂肾病。糖尿病肾病患者NLR及尿NGAL明显升高。

关键词: 炎症, 糖尿病, 肾病, 造影剂

Abstract: Objective To compare the neutrophil to lymphocyte ratio(NLR) and NGAL for contrastinduced nephropathy(CIN) predictive value in patients with type 2 diabetes mellitus. Methods A total of 88 patients with enhanced CT of type 2 diabetes mellitus were selected. The blood routine examination, SCr，CysC, hsCRP and NGAL were measured before enhanced CT, after 6 hours, 24 hours and 48 hours of enhanced CT. According to the results of tourine MA/Cr, the patients were divided into two groups, diabetic nephropathy(DN) and non DN group. Based on the diagnosis of CIN, the 88 patients were divided into CIN group(n=82) and normal group(n=6) to analyze the association of NLR and NGAL, and to compare the predictive value of NLR and other indexes.Results Totally six patients (6.8%) with DN suffered from CIN after enhanced CT. NLR and NGAL were higher in patients with DN than patients without DN（P＜0.05）. Pearson correlation analysis showed that NLR was positively associated with SCr（r=0.785，P=0.012） and NGAL （r=0.764，P=0.018）. After adjustment for some factors, according to the logistics regression, NLR was still a risk factor of CIN（P＜0.05）.Conclusion DN patients are more likely to have CIN. NLR and urine NGAL were higher in patients with DN.

Key words: inflammation；diabetes mellitus；nephrosis, contrast media

谷晓岚1，张德龙2，李欣宇1，刘颖姝1，李宁1，高政南1. 比较中性粒细胞与淋巴细胞比值与传统炎性指标对2型糖尿病患者增强CT后造影剂肾病的预测价值[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2019.12.008.

Gu Xiaolan1, Zhang Delong2, Li Xinyu1, Liu Yingshu1, Li Ning1, Gao Zhengnan1. Comparison of neutrophil to lymphocyte ratio and traditional inflammatory markers in predicting for contrastinduced nephropathy in patients with type 2 diabetes mellitus[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.12.008.

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https://huicui.hebmu.edu.cn/CN/Y2019/V34/I12/1094

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比较中性粒细胞与淋巴细胞比值与传统炎性指标对2型糖尿病患者增强CT后造影剂肾病的预测价值

Comparison of neutrophil to lymphocyte ratio and traditional inflammatory markers in predicting for contrastinduced nephropathy in patients with type 2 diabetes mellitus

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