中国人群中血糖波动与2型糖尿病视网膜病变关系的meta分析

doi:10.3969/j.issn.1004-583X.2020.01.002

临床荟萃

中国人群中血糖波动与2型糖尿病视网膜病变关系的meta分析

河北医科大学第二医院内分泌科，河北石家庄 050000

出版日期:2020-01-20 发布日期:2020-03-18
通讯作者: 王瑞英, Email: wry0616@126.com

Meta analysis of the relationship between blood glucose fluctuations and type 2 diabetic retinopathy in Chinese population

Department of Endocrinology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

Online:2020-01-20 Published:2020-03-18
Contact: Corresponding author: Wang Ruiying, Email: wry0616@126.com

摘要/Abstract

摘要： 目的通过比较血糖波动在2型糖尿病伴视网膜病变（diabetic retinopathy, DR）与2型糖尿病不伴视网膜病变（nondiabetic retinopathy, NDR）人群中的差异，探讨血糖波动与DR的关系。方法全面检索数据库，纳入比较DR患者与NDR患者血糖波动的文献17篇，采用RevMan5.3软件和STATA12.0软件进行meta分析。结果在纳入的17项研究中， DR组的平均血糖波动幅度（mean amplitude of glycemic excursion, MAGE）明显高于NDR组［加权均数差（weighted mean difference, WMD）及95%CI为2.12(1.66，2.58)，P＜0.01］。在纳入的9项研究中，非增殖期糖尿病视网膜病变（nonproliferative diabetic retinopathy, NPDR）组的MAGE明显低于增殖期糖尿病视网膜病变（proliferative diabetic retinopathy, PDR）组［WMD及95%CI为-1.09(-1.42，-0.77)，P<0.01］。NPDR组的MAGE明显高于NDR组［WMD及95%CI为1.52（1.25，1.79），P<0.01］。结论从NDR组到NPDR组再到PDR组，平均血糖波动幅度呈逐步增大趋势。

关键词: 糖尿病, , 2型, 血糖波动, 糖尿病视网膜病变, meta分析

Abstract: Objective To compare the difference of glucose variability between people with type 2 diabetic retinopathy and those without retinopathy in order to explore the relationship between glucose variability and type 2 diabetic retinopathy.Methods A total of 17 studies were included to compare the glucose variability of patients with type 2 diabetic retinopathy and those without retinopathy by searching database comprehensively.RevMan5.3 software and STATA12.0 software were adopted for the meta analysis.Results Among the 17 studies, mean amplitude of glycemic excursion(MAGE) of the diabetic retinopathy（DR） group was significantly higher than that of the nondiabetic retinopathy(NDR) group (weighted mean difference［WMD］ and 95%CI 2.12［1.66, 2.58］, P<0.01). Of the 9 included studies, the MAGE of the nonproliferative diabetic retinopathy (NPDR) group was significantly lower than that of the proliferative diabetic retinopathy (PDR) group(WMD and 95%CI -1.09［-1.42，-0.77］, P<0.01). Compared with the NDR group, MAGE were significantly higher in the NPDR group (WMD and 95%CI 1.52［1.25, 1.79］, P<0.01). Conclusion From diabetic nonretinopathy group, nonproliferative retinopathy group to proliferative retinopathy group, the glucose variability presents a gradually increasing trend.

Key words: diabetes mellitus, , type 2；glucose variability；diabetic retinopathy, meta , analysis

路阳，王瑞英，杜雅楠，张筱涵. 中国人群中血糖波动与2型糖尿病视网膜病变关系的meta分析[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2020.01.002.

Lu Yang, Wang Ruiying, Du Yanan, Zhang Xiaohan. Meta analysis of the relationship between blood glucose fluctuations and type 2 diabetic retinopathy in Chinese population[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2020.01.002.

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https://huicui.hebmu.edu.cn/CN/Y2020/V35/I1/13

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中国人群中血糖波动与2型糖尿病视网膜病变关系的meta分析

Meta analysis of the relationship between blood glucose fluctuations and type 2 diabetic retinopathy in Chinese population

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