抗MDA5抗体阳性皮肌炎合并间质性肺病的研究进展

doi:10.3969/j.issn.1004-583X.2022.11.016

摘要/Abstract

摘要：

抗黑色素瘤分化相关基因5(melanoma differentiation-associated gene 5,MDA5)抗体是临床无肌病皮肌炎(clinically amyopathic dermatomyositis,CADM)和皮肌炎(dermatomyositis,DM)患者中一种特异性较高的抗体。相关研究表明抗MDA5抗体阳性DM患者更易发展为快速进展性肺间质病变(rapidly progressive interstitial lung disease,RPILD),尤其是在亚裔人群中,这类患者病情较重,死亡率极高。目前对这种疾病的发病机制仍不明确,治疗在很大程度上仍然是经验性的。我们将在这篇综述中总结MDA5+ DM-ILD近年的研究进展,期望能对临床医生有所帮助。

中图分类号:

R563.9

吴锦秀, 苗健龙. 抗MDA5抗体阳性皮肌炎合并间质性肺病的研究进展[J]. 临床荟萃, 2022, 37(11): 1048-1052.

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https://huicui.hebmu.edu.cn/CN/Y2022/V37/I11/1048

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抗MDA5抗体阳性皮肌炎合并间质性肺病的研究进展

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