血脂、同型半胱氨酸与帕金森病合并认知障碍相关性

doi:10.3969/j.issn.1004-583X.2022.02.006

摘要/Abstract

摘要：

目的探讨血脂、同型半胱氨酸(Hcy)水平与帕金森病(PD)合并认知障碍程度的相关性。方法收集2019年9月至2021年8月在锦州市中心医院神经内科就诊PD患者100例以及健康体检者50例分别纳入PD组和对照组,PD组根据蒙特利尔认知评价量表(MoCA)评分分为PD认知正常(PD-NC)亚组38例、PD轻度认知障碍(PD-MCI)亚组32例和PD痴呆(PDD)亚组30例。检测所有患者血脂和血清Hcy水平,探究组间指标差异,并分析以上指标与认知障碍程度的相关性。结果 PD组Hcy水平显著高于对照组(P<0.05),总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组(P<0.05)。PD-NC亚组、PD-MCI亚组及PDD亚组的TG、LDL-C、Hcy水平差异有统计学意义(P<0.05),Logistic回归分析显示Hcy是PD认知障碍的独立危险因素(P<0.05)。结论 PD患者TG、LDL-C、Hcy水平与其认知障碍程度有一定的相关性。

关键词: 帕金森病, 认知障碍, 血脂, 同型半胱氨酸

Abstract:

Objective To investigate the correlation between the levels of blood lipid and homocysteine (Hcy) and the degree of cognitive impairment in Parkinson's disease (PD).Methods A total of 100 PD patients and 50 healthy people admitted to the Department of Neurology of Jinzhou Central Hospital during Sept 2019 - Aug 2021 were respectively registered into PD group and control group. According to the score of Montreal cognitive Assessment(MoCA), patients in PD group were divided into 38 patients with normal cognition (PD-NC), 32 patients with mild cognitive impairment (PD-MCI) and 30 patients with PD dementia (PDD). The aim was to detect levels of blood lipid and serum Hcy of all patients, explore the differences of indicators between groups, and analyze the correlation between the above indicators and the degree of cognitive impairment.Results Compared with control group, PD group had significantly higher level of Hcy (P<0.05), lower levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol(LDL-C) (P<0.05), significant differences existed in the levels of TG, LDL-C and Hcy among PD-NC subgroup, PD-MCI subgroup and PDD subgroup (P < 0.05). Logistic regression analysis showed that Hcy was an independent risk factor for PD cognitive impairment (P<0.05).Conclusion There is a certain correlation between the levels of TG, LDL-C and Hcy and the degree of cognitive impairment for PD patients.

Key words: Parkinson's disease, cognitive impairment, blood lipids, homocysteine

中图分类号:

R742.5

郭畅, 沈慧楠, 孙艺萌, 王东玉. 血脂、同型半胱氨酸与帕金森病合并认知障碍相关性[J]. 临床荟萃, 2022, 37(2): 128-132.

Guo Chang, Shen Huinan, Sun Yimeng, Wang Dongyu. Correlation between blood lipid and homocysteine and cognitive impairment in Parkinson's disease[J]. Clinical Focus, 2022, 37(2): 128-132.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2022.02.006

https://huicui.hebmu.edu.cn/CN/Y2022/V37/I2/128

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参考文献 32

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组别	例数	TG(mmol/L)	TC(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	Hcy(μmol/L)
对照组	50	1.45±0.35	4.74±0.93	1.35±0.20	2.87±0.60	9.67±2.67
PD组	100	1.29±0.44^*	4.34±0.91^*	1.28±0.28	2.55±0.48^*	15.03±5.51^*
t值		2.373	2.469	1.804	3.626	-8.021
P值		0.019	0.015	0.074	0.000	0.000

组别	例数	TG(mmol/L)	TC(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	Hcy(μmol/L)
对照组	50	1.45±0.35	4.74±0.93	1.35±0.20	2.87±0.60	9.67±2.67
PD组	100	1.29±0.44^*	4.34±0.91^*	1.28±0.28	2.55±0.48^*	15.03±5.51^*
t值		2.373	2.469	1.804	3.626	-8.021
P值		0.019	0.015	0.074	0.000	0.000

组别	例数	TG(mmol/L)	TC(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	Hcy(μmol/L)
PD-NC亚组	38	1.15±0.42	4.13±0.86	1.31±0.28	2.40±0.46	12.18±4.22
PD-MCI亚组	32	1.29±0.46	4.36±0.95	1.24±0.29	2.58±0.46	15.27±4.48^*
PDD亚组	30	1.49±0.40^*	4.60±0.90	1.28±0.27	2.69±0.50^*	18.38±6.11^*#
F值		5.070	2.249	0.564	3.276	13.284
P值		0.008	0.111	0.571	0.042	0.000

组别	例数	TG(mmol/L)	TC(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	Hcy(μmol/L)
PD-NC亚组	38	1.15±0.42	4.13±0.86	1.31±0.28	2.40±0.46	12.18±4.22
PD-MCI亚组	32	1.29±0.46	4.36±0.95	1.24±0.29	2.58±0.46	15.27±4.48^*
PDD亚组	30	1.49±0.40^*	4.60±0.90	1.28±0.27	2.69±0.50^*	18.38±6.11^*#
F值		5.070	2.249	0.564	3.276	13.284
P值		0.008	0.111	0.571	0.042	0.000

危险因素	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
危险因素	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
TG	0.625	0.582	1.154	0.283	1.869	0.597	5.850
LDL-C	0.156	0.562	0.077	0.781	1.169	0.389	3.515
Hcy	0.169	0.056	8.950	0.003	1.184	1.060	1.322