他汀类药物辅助抗结核作用机制及临床价值

doi:10.3969/j.issn.1004-583X.2022.02.014

摘要/Abstract

摘要：

他汀类药物是目前临床广泛应用的调脂药物,此外,还具有诱导自噬和吞噬体成熟、抗氧化应激等多种作用。作为结核病宿主导向治疗候选药物之一,他汀类药物可通过抗炎、免疫调节、影响胆固醇代谢等多种机制,具有降低结核病发病风险,预防糖尿病状态下的结核病发展,增加抗结核药物抗菌活性,缩短结核病的治疗时间等多重优势,且在慢性阻塞性肺疾病、哮喘等其他慢性呼吸系统疾病中具有一定的临床价值。结合目前结核病药物研究现状及诊疗进展,本文就他汀类药物在结核病防治中的作用机制及临床应用价值作一综述,旨在为结核病防治提供一定理论依据。

中图分类号:

R521
R587.1

李百远, 李元军. 他汀类药物辅助抗结核作用机制及临床价值[J]. 临床荟萃, 2022, 37(2): 166-169.

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https://huicui.hebmu.edu.cn/CN/Y2022/V37/I2/166

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