临床荟萃 ›› 2020, Vol. 35 ›› Issue (12): 1061-1066.doi: 10.3969/j.issn.1004583X.2020.12.001

• 循证研究 •    下一篇

维生素D水平与抽动障碍关系的meta分析

  

  1. 1.福建医科大学附属协和医院 儿科,福建省临床重点专科,福建医科大学神经心理研究中心,福建 福州 350001;
    2.厦门大学附属第一医院 儿科,厦门市儿科重点实验室,厦门大学医学院儿童医学研究所,福建 厦门 361003
  • 出版日期:2020-12-20 发布日期:2020-11-27
  • 通讯作者: 陈先睿,Email:chenxianruimiao@163.com
  • 基金资助:
    国家重点研发计划项目----儿童脑发育障碍的早期识别和综合干预(2016YFC1306204);福建省科技创新联合基金项目资助----生命早期维生素D营养对大鼠注意、多动的影响及机制(2018Y9056)

Meta analysis of the relationship between vitamin D levels and tic disorder

  1. 1.Department of Pediatrics,  Fujian Medical University Union Hospital,  Fuzhou 350001, Fujian, China;
    2.Department of Pediatrics,  the First Affiliated Hospital of Xiamen University,  Xiamen 361003,  China
  • Online:2020-12-20 Published:2020-11-27
  • Contact: Corresponding author: Chen Xianrui,Email: chenxianruimiao@163.com

摘要: 目的  评价分析儿童抽动障碍与维生素D(Vitamin D, VitD)水平的临床关系。方法  通过检索中国知网、万方数据库、维普中文期刊数据库、Cochrane 图书馆、PubMed和EMbase上的中英文相关文献,检索时间均为建库至2020年8月。2名研究者独立提取纳入文献数据并进行文献偏倚风险评价,采用RevMan5.3软件进行Meta分析。结果  最终纳入4篇文献进行Meta分析,总计1 043例,其中TD组620例,健康对照组423例。本研究显示TD组儿童血清25羟基VitD平均水平低于健康对照组(MD=5.24,95%CI:9.75~0.72,P<0.02)。亚组分析显示:TTD与CTD组儿童的血清VitD水平差异无统计学意义(MD=1.55,95%CI:-2.43~5.53,P<0.45);CTD组与TS组儿童血清VitD水平差异无统计学意义(MD=1.06,95%CI:-0.08~2.21,P=0.07);TTD组与TS组儿童血清VitD水平差异无统计学意义(MD=3.47,95%CI:-1.16~8.10,P=0.14)。4篇文献显示TD组男性儿童与健康组差异无统计学意义(OR=1.36,95%CI:0.80~2.32,P=0.25)。TD儿童较健康组的年龄比较差异无统计学意义(OR=0.03,95%CI:-0.33~0.39,P=0.86)。结论本  meta分析表明TD儿童的血清25羟基VitD水平较健康儿童低,但亚组之间无差别。

关键词: 抽搐性运动障碍, 维生素D, 儿童

Abstract: Objective  To evaluate and analyze the clinical relationship between tic disorder in children and Vitamin D(VitD) status. Methods  Relevant Chinese and English literature from CNKI,  Wanfang database,  VIP database,  Cochrane Library,  PubMed and EMbase were all searched from the establishment of the database to August 2020. Two researchers independently extracted the included literature data and evaluated the risk of literature bias. RevMan5.3 software was used for Metaanalysis. Results  Finally, four literatures were included for Meta analysis, with a total of 1  043 cases,  including 620 cases in TD group and 423 cases in healthy control group. This study showed that the average level of serum 25 hydroxyl VitD in the TD group was lower than that in the healthy control group(MD=-5.24,95%CI:-9.75-0.72,P<0.02). Subgroup analysis showed that there was no statistically significant differences in serum VitD levels between TTD and CTD groups(MD=1.55,95%CI:-2.435.53,P<0.45).There was no significant difference in serum VitD levels between CTD group and TS group(MD=1.06,95%CI:-0.082.21,P=0.07).There was no significant difference in serum VitD between TTD group and TS group(MD=3.47,95%CI:-1.168.10,P=0.14). Four literatures showed that there was no statistical difference in male children between TD group and healthy group (OR=1.36,  95%CI: 0.802.32,  P=0.25). There was no statistically significant difference in the age of children between TD group and healthy group(OR=0.03,  95%CI: -0.330.39,  P=0.86). Conclusion  This metaanalysis showed that the serum 25 hydroxyl VitD level of TD children was lower than that of healthy children, with no difference among the subgroups.

Key words: tic disorder, Vitamin D, children

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