解郁安神颗粒联合帕罗西汀治疗老年冠心病稳定型心绞痛伴抑郁的临床研究

doi:10.3969/j.issn.1004-583X.2021.02.005

摘要/Abstract

摘要：

目的观察解郁安神颗粒联合帕罗西汀治疗老年冠心病稳定型心绞痛伴抑郁患者的临床疗效。方法 86例老年冠心病稳定型心绞痛合并抑郁的患者随机分为观察组和对照组。对照组给予西医常规扩冠、抗血小板聚集、调脂、降低心肌耗氧量等冠心病治疗药物,然后口服帕罗西汀片,20 mg/d。观察组在对照组基础上,给予加用解郁安神颗粒,早晚冲服,5 g/次。比较两组治疗前后的疗效、中医证候评分、汉密尔顿抑郁量表、抑郁自评量表。结果观察组总有效率为88.10%,对照组总有效率为68.29%(P<0.05);两组中医症候、汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)评分,均较治疗前降低(P<0.05),且治疗后观察组评分低于对照组(P<0.05)。结论解郁安神颗粒联合帕罗西汀不仅对改善患者抑郁情绪有显著作用,并且可以缓解冠心病稳定型心绞痛症状,且临床效果优于单用帕罗西汀组,值得推广与应用。

关键词: 心绞痛, 稳定型, 抑郁, 解郁安神颗粒, 帕罗西汀

Abstract:

Objective To observe clinical effects of Jieyu Anshen Particles combined with paroxetine in treating elderly patients with coronary stable angina pectoris and depression. Methods Eighty-six elderly patients with coronary stable angina pectoris complicated with depression were randomly divided into observation group and control group. The patients in control group was treated with drugs for coronary heart disease such as western medicine routine coronary artery expansion, antiplatelet aggregation, lipid regulation, and reduction of myocardial oxygen consumption, and then orally took paroxetine tablets with 20 mg/d. Based on the control group, the patients in observation group received Jieyu Anshen Particles and took each dose in 5 g in the morning and evening. The effiicacy, TCM syndrome scores, Hamilton Depression Scale(HAMD) scores and Self-rating Depression Scale(SDS) scores of patients in two groups before and after treatment were compared. Results The overall response rate of patients in observation group and control group was 88.10% and 68.29%, respectively(P<0.05). The scores of TCM symptoms, HAMD and SDS of patients in two groups were lower than before treatment (P<0.05), and the scores of observation group after treatment were lower than those of control group (P<0.05). Conclusion Jieyu Anshen Particles combined with paroxetine can not only improve the depression but also relieve the symptoms of coronary heart disease complicated with stable angina pectoris, and corresponding clinical effect is better than that of paroxetine alone, being worthy of promotion and application.

Key words: angina, stable, depression, Jieyu Anshen particles, paroxetine

中图分类号:

R541.4

解冰, 赵凤凤, 陈亮. 解郁安神颗粒联合帕罗西汀治疗老年冠心病稳定型心绞痛伴抑郁的临床研究[J]. 临床荟萃, 2021, 36(2): 121-124.

Xie Bing, Zhao Fengfeng, Chen Liang. Clinical study of Jieyu Anshen Particles combined with paroxetine in treating senile coronary stable angina pectoris with depression[J]. Clinical Focus, 2021, 36(2): 121-124.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.02.005

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I2/121

图/表 3

参考文献 21

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组别	例数	显效 (例)	有效 (例)	无效 (例)	总有效率 [例(%)]
观察组	42	15	22	5	37(88.10)
对照组	41	9	19	13	28(68.29)
统计值			Z=-2.120		χ²=4.790
P值			0.034		0.028

组别	例数	显效 (例)	有效 (例)	无效 (例)	总有效率 [例(%)]
观察组	42	15	22	5	37(88.10)
对照组	41	9	19	13	28(68.29)
统计值			Z=-2.120		χ²=4.790
P值			0.034		0.028

组别	例数	干预前	干预后
观察组	42	24.19±3.46	13.40±5.17^*
对照组	41	23.95±3.86	16.41±5.38^*
t值		0.298	-2.599
P值		0.767	0.011

组别	例数	干预前	干预后
观察组	42	24.19±3.46	13.40±5.17^*
对照组	41	23.95±3.86	16.41±5.38^*
t值		0.298	-2.599
P值		0.767	0.011

组别	例数	HAMD		SDS
组别	例数	干预前	干预后	干预前	干预后
观察组	42	24.64±3.44	14.40±3.99^*	71.60±4.21	57.60±3.60^*
对照组	41	25.20±3.65	17.44±3.66^*	72.22±5.38	62.63±3.35^*
t值		-0.710	-3.605	-0.589	-6.593
P值		0.480	0.001	0.557	0.000