瞬时受体电位家族在肠易激综合征中的作用机制研究进展

doi:10.3969/j.issn.1004-583X.2021.05.016

摘要/Abstract

摘要：

瞬时受体电位(transient receptor potential, TRP)家族是一类位于细胞膜和胞内细胞器膜的阳离子配体门控通道蛋白。TRP通道广泛分布于哺乳动物的神经元和非神经细胞,在温度、pH值、机械力等多种物理因素和各种内、外源性的化学介质刺激下,参与躯体和内脏伤害性信号的感觉及传导,对肠易激综合征(irritable bowel syndrome, IBS)患者内脏高敏感性的产生有重要的作用。IBS患者结直肠中TRP通道的表达水平和功能发生明显改变,以TRP通道作为治疗IBS新的药物靶点在研究中取得了初步的成效,为治疗IBS提供了新的依据。

关键词: 肠易激综合征, 瞬时受体电位通道, 内脏高敏感, 感觉传导

中图分类号:

R574.62

肖文静, 罗和生. 瞬时受体电位家族在肠易激综合征中的作用机制研究进展[J]. 临床荟萃, 2021, 36(5): 467-470.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.05.016

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I5/467

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