BNP、Hcy、AVP、CPT在慢性肺源性心脏病患者病情发展及疗效评估中的应用

doi:10.3969/j.issn.1004-583X.2021.07.004

摘要/Abstract

摘要：

目的探究血清脑钠肽(BNP)、同型半胱氨酸(Hcy)、血清精氨酸加压素(AVP)、和肽素(CPT)在慢性肺源性心脏病(肺心病)患者病情发展及疗效评估中的应用价值。方法选取2020年1月至2021年1月本院呼吸内科诊治的肺心病患者80例,其中肺心病缓解期42例、肺心病急性加重期38 例,选择同期于医院进行体检的健康人群60例为对照组。检测并对比3组BNP、Hcy、AVP、CPT水平,并对肺心病患者进行低流量吸氧,通畅气道,控制心力衰竭等治疗,记录并对比80例肺心病患者治疗前后BNP、Hcy、AVP、CPT水平变化。结果肺心病患者BNP、Hcy、AVP、CPT水平均显著高于对照组。治疗后,两组BNP、Hcy、AVP、CPT水平均显著降低,肺心病急性加重期组BNP、Hcy、AVP、CPT水平依然均高于肺心病缓解期(P<0.05)。结论肺心病患者BNP、Hcy、AVP、CPT水平高于正常对照组,且随着病情的加重,BNP、Hcy、AVP、CPT水平越高,加强BNP、Hcy、AVP、CPT水平的监测,有利于肺心病患者的防治。

关键词: 肺心病, 脑钠肽, 同型半胱氨酸, 精氨酸加压素, 和肽素

Abstract:

Objective To investigate the value of brain natriuretic peptide(BNP), homocysteine(Hcy), arginine vasopressin(AVP), and copeptin(CPT) in disesae development and efficacy evaluation of patients with chronic pulmonary heart disease(CPHD).Methods Totally 80 CPHD patients, including 42 in remission stage and 38 in exacerbation phase were enrolled from January 2020 to January 2021, 60 patients without CPHD, who came to our hospital for a physical examination at the same time, were served as control group. BNP, Hcy, AVP, CPT of all patients were obtained. Low flow oxygen, clear airway, and heart failure control as well as other therapies were performed in CPHD patients, and BNP, Hcy, AVP, CPT of those 80 CPHD patients were recorded before and after treatment.Results BNP, Hcy, AVP, CPT of CPHD patients were significantly higher than those of without CPHD patients. Before treatment for CPHD patients, BNP, Hcy, AVP, CPT in exacerbation phase were higher than those in remission stage (P<0.05), but they were significant decrease in all CPHD patients after treatment, while the items were still higher in exacerbation phase than in remission stage (P<0.05).Conclusion Compared with those without CPHD, BNP, Hcy, AVP, CPT of CPHD patients were significantly higher with disease development, strengthened inspection will be beneficial to CPHD patients.

Key words: pulmonary heart disease, brain natriuretic peptide, homocysteine, arginine vasopressin, copeptin

中图分类号:

R541.5

卫青园, 殷旭芳, 李娇娇. BNP、Hcy、AVP、CPT在慢性肺源性心脏病患者病情发展及疗效评估中的应用[J]. 临床荟萃, 2021, 36(7): 600-603.

Wei Qingyuan, Yin Xufang, Li Jiaojiao. Application of BNP, Hcy, AVP, CPT in disease development and efficacy evaluation of patients with chronic pulmonary heart disease[J]. Clinical Focus, 2021, 36(7): 600-603.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.07.004

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I7/600

图/表 2

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组别	例数	性别(例)		年龄 (岁)	BMI (kg/m²)
组别	例数	男	女	年龄 (岁)	BMI (kg/m²)
对照组	60	29	31	63.95±7.75	23.52±4.52
肺心病缓解期组	42	25	17	62.29±7.83	23.75±4.60
肺心病急性加重期组	38	27	11	63.98±7.74	23.50±4.55
χ²/F值		1.166		0.680	0.404
P值		0.280		0.508	0.960

组别	例数	性别(例)		年龄 (岁)	BMI (kg/m²)
组别	例数	男	女	年龄 (岁)	BMI (kg/m²)
对照组	60	29	31	63.95±7.75	23.52±4.52
肺心病缓解期组	42	25	17	62.29±7.83	23.75±4.60
肺心病急性加重期组	38	27	11	63.98±7.74	23.50±4.55
χ²/F值		1.166		0.680	0.404
P值		0.280		0.508	0.960

组别	例数	BNP(pg/mL)		Hcy(μmol/L)		AVP(ng/L)		CPT(ng/mL)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	60	67.90±11.25	-	13.40±4.15	-	4.25±0.5	-	2.8±0.5	-
肺心病缓解期组	42	265.50±38.80	120.30±28.50^△	19.40±6.80	14.30±4.50^△	54.50±4.50	20.50±4.15^△	7.5±0.8	5.2±0.5^△
肺心病急性加重期组	38	470.15±105.25	191.20±33.50^*#△	28.35±8.12	18.20±5.15^*#△	130.50±8.50	35.65±8.25^*#△	13.0±1.5	7.3±0.7^*#△
F值		545.556	10.224	66.574	3.615	7220.932	10.525	1343.555	15.550
P值		<0.01	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01

组别	例数	BNP(pg/mL)		Hcy(μmol/L)		AVP(ng/L)		CPT(ng/mL)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	60	67.90±11.25	-	13.40±4.15	-	4.25±0.5	-	2.8±0.5	-
肺心病缓解期组	42	265.50±38.80	120.30±28.50^△	19.40±6.80	14.30±4.50^△	54.50±4.50	20.50±4.15^△	7.5±0.8	5.2±0.5^△
肺心病急性加重期组	38	470.15±105.25	191.20±33.50^*#△	28.35±8.12	18.20±5.15^*#△	130.50±8.50	35.65±8.25^*#△	13.0±1.5	7.3±0.7^*#△
F值		545.556	10.224	66.574	3.615	7220.932	10.525	1343.555	15.550
P值		<0.01	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01	<0.01