调节小胶质细胞反应性:糖尿病视网膜病变新见解

doi:10.3969/j.issn.1004-583X.2023.04.014

摘要/Abstract

摘要：

糖尿病视网膜病变(diabetic retinopathy,DR)是一种微血管疾病,同时也被认为是一种影响所有视网膜细胞的神经退行性病变。小胶质细胞是中枢神经系统的主要免疫细胞,同时作为视网膜的常驻单核细胞,其具有双重表型。在健康的视网膜中,小胶质细胞通过释放神经保护因子和抗炎因子参与防御性免疫系统。然而,持续的高血糖状态引起的组织应激使小胶质细胞过度反应,产生促炎细胞因子和趋化因子,导致神经炎症。因此,本文就DR相关的小胶质细胞的激活及其对DR的影响,讨论了调节小胶质细胞介导的炎症反应在治疗该疾病中的可能性。

中图分类号:

R587.2

易静静, 圈启芳, 马婕. 调节小胶质细胞反应性:糖尿病视网膜病变新见解[J]. 临床荟萃, 2023, 38(4): 364-368.

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https://huicui.hebmu.edu.cn/CN/Y2023/V38/I4/364

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参考文献 41

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调节小胶质细胞反应性:糖尿病视网膜病变新见解

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