维生素D与类风湿关节炎关系的研究进展

doi:10.3969/j.issn.1004-583X.2024.11.014

摘要/Abstract

摘要：

类风湿关节炎(rheumatoid arthritis,RA)是风湿免疫科常见的一种自身免疫性疾病,其基本病理表现为滑膜炎,逐渐出现关节软骨和骨质破坏,最终导致关节的畸形和功能丧失,并且可出现肺、心血管及肿瘤等病变。维生素D的主要功能是维持细胞内稳态,此外,还具有免疫调节、抗炎、抗纤维化和抗氧化作用;维生素D缺乏一方面增加促炎细胞因子的产生加剧炎症反应,另一方面通过破骨细胞的活化导致骨质流失。治疗上使用维生素D治疗RA在临床试验中展现出较好的疗效,有望成为未来治疗的新方向。本综述全面梳理了维生素D与RA关系的研究现状,明确了当前研究的热点,为进一步深入探究RA的发病机制、探索更有效的治疗手段奠定了基础,旨在为临床医生在RA的治疗上提供重要的知识更新与思路拓展。

关键词: 关节炎, 类风湿, 维生素D, 自身免疫性疾病, 系统性综述

中图分类号:

R539.22

明国庆, 孟景红. 维生素D与类风湿关节炎关系的研究进展[J]. 临床荟萃, 2024, 39(11): 1047-1051.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2024.11.014

https://huicui.hebmu.edu.cn/CN/Y2024/V39/I11/1047

参考文献 54

[1]	Illescas-Montes R, Melguizo-Rodríguez L, Ruiz C, et al. Vitamin D and autoimmune diseases[J]. Life Sci, 2019, 233:233116744.
[2]	Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on human health and disease[J]. Nutrients, 2020, 12(7):2097.
[3]	Christakos S, Dhawan P, Verstuyf A, et al. Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects[J]. Physiol Rev, 2016, 96(1): 365-408. doi: 10.1152/physrev.00014.2015 pmid: 26681795
[4]	Schwetz V, Trummer C, Pandis M, et al. Effects of Vitamin D supplementation on bone turnover markers: A randomized controlled trial[J]. Nutrients, 2017, 9(5):432.
[5]	Gallieni M, Cozzolino M, Fallabrino G, et al. Vitamin D: Physiology and pathophysiology[J]. Int J Artif Organs, 2009, 32(2): 87-94. doi: 10.1177/039139880903200205 pmid: 19363780
[6]	张炜, 沈奕, 李晓淼, 等. 鲑鱼降钙素对绝经后骨质疏松症的治疗[J]. 中华关节外科杂志(电子版), 2011, 5(4): 518-520.
[7]	Dimitrov V, Salehi-Tabar R, An BS, et al. Non-classical mechanisms of transcriptional regulation by the vitamin D receptor: Insights into calcium homeostasis, immune system regulation and cancer chemoprevention[J]. J Steroid Biochem Mol Biol, 2014, 144 Pt A:74-80.
[8]	Corcoran A, Nadkarni S, Yasuda K, et al. Biological evaluation of double point modified analogues of 1, 25-Dihydroxyvitamin D(2) as potential anti-leukemic agents[J]. Int J Mol Sci, 2016, 17(2):91.
[9]	Colotta F, Jansson B, Bonelli F. Modulation of inflammatory and immune responses by vitamin D[J]. J Autoimmun, 2017, 85:78-97. doi: S0896-8411(17)30463-8 pmid: 28733125
[10]	Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: An endocrine society scientific statement[J]. Endocr Rev, 2012, 33(3): 456-492. doi: 10.1210/er.2012-1000 pmid: 22596255
[11]	Piotrowska A, Wierzbicka J, Zmijewski MA. Vitamin D in the skin physiology and pathology[J]. Acta Biochim Pol, 2016, 63(1): 17-29. doi: 10.18388/abp.2015_1104 pmid: 26824295
[12]	Epstein S, Stern PH, Bell NH, et al. Evidence for abnormal regulation of circulating 1 alpha, 25-dihydroxyvitamin D in patients with pulmonary tuberculosis and normal calcium metabolism[J]. Calcif Tissue Int, 1984, 36(5): 541-544.
[13]	Ota K, Dambaeva S, Kim MW, et al. 1, 25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses[J]. Eur J Immunol, 2015, 45(11): 3188-3199.
[14]	Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications[J]. Chem Biol, 2014, 21(3): 319-329.
[15]	Christakos S, Hewison M, Gardner DG, et al. Vitamin D: Beyond bone[J]. Ann N Y Acad Sci, 2013, 1287(1): 45-58.
[16]	Sassi F, Tamone C, D'Amelio P. Vitamin D: Nutrient, hormone, and immunomodulator[J]. Nutrients, 2018, 10(11):1656.
[17]	Garcia-Carrasco M, Jimenez-Herrera EA, Galvez-Romero JL, et al. Vitamin D and sjogren syndrome[J]. Autoimmun Rev, 2017, 16(6): 587-593. doi: S1568-9972(17)30099-X pmid: 28411165
[18]	Vieira VM, Hart JE, Webster TF, et al. Association between residences in U.S. northern latitudes and rheumatoid arthritis: A spatial analysis of the Nurses' Health Study[J]. Environ Health Perspect, 2010, 118(7): 957-961.
[19]	Richards JB, Valdes AM, Gardner JP, et al. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women[J]. Am J Clin Nutr, 2007, 86(5): 1420-1425. doi: 10.1093/ajcn/86.5.1420 pmid: 17991655
[20]	van Hamburg JP, Asmawidjaja PS, Davelaar N, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production[J]. Arthritis Rheum, 2011, 63(1): 73-83.
[21]	Sato K, Suematsu A, Okamoto K, et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction[J]. J Exp Med, 2006, 203(12): 2673-2682. doi: 10.1084/jem.20061775 pmid: 17088434
[22]	Filer A. The fibroblast as a therapeutic target in rheumatoid arthritis[J]. Curr Opin Pharmacol, 2013, 13(3): 413-419. doi: 10.1016/j.coph.2013.02.006 pmid: 23562164
[23]	Liu Y, Wan X, Yuan Y, et al. Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response[J]. J Zhejiang Univ Sci B, 2021, 22(7): 590-598.
[24]	Jeffery LE, Burke F, Mura M, et al. 1, 25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3[J]. J Immunol, 2009, 183(9): 5458-5467. doi: 10.4049/jimmunol.0803217 pmid: 19843932
[25]	Urry Z, Chambers ES, Xystrakis E, et al. The role of 1alpha, 25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells[J]. Eur J Immunol, 2012, 42(10): 2697-2708. doi: 10.1002/eji.201242370 pmid: 22903229
[26]	Urry Z, Xystrakis E, Richards DF, et al. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha, 25-dihydroxyvitamin D3 abrogates regulatory function[J]. J Clin Invest, 2009, 119(2): 387-398. doi: 10.1172/JCI32354 pmid: 19139565
[27]	Moore KW, de Waal Malefyt R, Coffman RL, et al. Interleukin-10 and the interleukin-10 receptor[J]. Annu Rev Immunol, 2001, 19683-19765.
[28]	Sakalyte R, Denkovskij J, Bernotiene E, et al. The expression of inflammasomes NLRP1 and NLRP3, toll-like receptors, and vitamin D receptor in synovial fibroblasts from patients with different types of knee arthritis[J]. Front Immunol, 2022, 12:767512.
[29]	Takahashi K, Nakayama Y, Horiuchi H, et al. Human neutrophils express messenger RNA of vitamin D receptor and respond to 1alpha, 25-dihydroxyvitamin D3[J]. Immunopharmacol Immunotoxicol, 2002, 24(3): 335-347.
[30]	Davies LC, Jenkins SJ, Allen JE, et al. Tissue-resident macrophages[J]. Nat Immunol, 2013, 14(10): 986-995. doi: 10.1038/ni.2705 pmid: 24048120
[31]	Tian R, Li X, Li Y, et al. 1, 25(OH)(2)D(3) promotes chondrocyte apoptosis and restores physical function in rheumatoid arthritis through the NF-kappaB signal pathway[J]. Biomed Pharmacother, 2018, 106:149-155. doi: S0753-3322(18)32398-9 pmid: 29957465
[32]	Erkilic B, Dalgic GS. The preventive role of vitamin D in the prevention and management of fibromyalgia syndrome[J]. Nutr Health, 2023, 29(2): 223-229.
[33]	贺志清, 来妞, 李景源. 血清25-羟维生素D和IgG4水平与类风湿关节炎患者骨质侵蚀的关系[J]. 检验医学与临床, 2023, 20(5): 585-588.
[34]	邹晋梅, 李思吟, 杨静, 等. 类风湿关节炎患者血清25-(OH)D₃水平与骨密度的关系[J]. 中国医药导报, 2019, 16(19): 109-112.
[35]	赵宁, 曹大伟, 张新日. 维生素D对特发性肺纤维化Ⅱ型肺泡上皮作用的研究进展[J]. 临床肺科杂志, 2022, 27(3): 454-458.
[36]	刘洋, 温鸿雁. 类风湿关节炎血清1, 25-二羟维生素D3水平与肺动脉压的关系[J]. 山西医科大学学报, 2018, 49(5): 528-531.
[37]	Clasen JL, Cole R, Aune D, et al. Vitamin D status and risk of rheumatoid arthritis: Systematic review and meta-analysis[J]. BMC Rheumatol, 2023, 7(1): 3.
[38]	Lee YH, Bae SC. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: A meta-analysis[J]. Clin Exp Rheumatol, 2016, 34(5): 827-833. pmid: 27049238
[39]	Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis: Results from the iowa women's health study[J]. Arthritis Rheum, 2004, 50(1): 72-77.
[40]	Arkema EV, Hart JE, Bertrand KA, et al. Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study[J]. Ann Rheum Dis, 2013, 72(4): 506-511. doi: 10.1136/annrheumdis-2012-202302 pmid: 23380431
[41]	Song GG, Bae SC, Lee YH. Association between vitamin D intake and the risk of rheumatoid arthritis: A meta-analysis[J]. Clin Rheumatol, 2012, 31(12): 1733-1739. doi: 10.1007/s10067-012-2080-7 pmid: 22941259
[42]	Park YE, Kim BH, Lee SG, et al. Vitamin D status of patients with early inflammatory arthritis[J]. Clin Rheumatol, 2015, 34(2): 239-246.
[43]	Di Franco M, Barchetta I, Iannuccelli C, et al. Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: A 12 month follow-up study[J]. BMC Musculoskelet Disord, 2015, 16:53.
[44]	Hajjaj-Hassouni N, Mawani N, Allali F, et al. Evaluation of vitamin D status in rheumatoid arthritis and its association with disease activity across 15 countries: “The COMORA study”[J]. Int J Rheumatol, 2017, 2017:5491676.
[45]	Chen M, Li W, Li L, et al. Ankylosing spondylitis disease activity and serum vitamin D levels: A systematic review and meta-analysis[J]. Medicine (Baltimore), 2022, 101(46): e31764.
[46]	Lin J, Liu J, Davies ML, et al. Serum vitamin D level and rheumatoid arthritis disease activity: Review and meta-analysis[J]. PLoS One, 2016, 11(1): e146351.
[47]	付文轶. 维生素D在类风湿关节炎及大鼠胶原诱导的关节炎模型中的作用及机制研究[D]. 沈阳: 中国医科大学, 2021.
[48]	Guan Y, Hao Y, Guan Y, et al. The Effect of Vitamin D supplementation on rheumatoid arthritis patients: A systematic review and meta-analysis[J]. Front Med (Lausanne), 2020, 7:596007.
[49]	Nguyen Y, Sigaux J, Letarouilly JG, et al. Efficacy of Oral Vitamin Supplementation in Inflammatory Rheumatic Disorders: A systematic review and meta-analysis of randomized controlled trials[J]. Nutrients, 2020, 13(1):107.
[50]	Yang J, Liu L, Zhang Q, et al. Effect of vitamin D on the recurrence rate of rheumatoid arthritis[J]. Exp Ther Med, 2015, 10(5): 1812-1816. pmid: 26640554
[51]	史晓飞, 武新峰, 田亚伟, 等. 1, 25二羟维生素D₃在老年类风湿关节炎治疗中的作用[J]. 河南科技大学学报(医学版), 2019, 37(3): 212-215.
[52]	Gopinath K, Danda D. Supplementation of 1, 25 dihydroxy vitamin D3 in patients with treatment naive early rheumatoid arthritis: A randomised controlled trial[J]. Int J Rheum Dis, 2011, 14(4): 332-339. doi: 10.1111/j.1756-185X.2011.01684.x pmid: 22004229
[53]	Li C, Yin S, Yin H, et al. Efficacy and Safety of 22-oxa-calcitriol in patients with rheumatoid arthritis: A phase II trial[J]. Med Sci Monit, 2018, 24:9127-9135.
[54]	Wei R, Christakos S. Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D[J]. Nutrients, 2015, 7(10): 8251-8260. doi: 10.3390/nu7105392 pmid: 26404359

维生素D与类风湿关节炎关系的研究进展

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