Abstract: ObjectiveTo evaluate the effect of myocardial perfusion of STEMI (STsegment elevation myocardial infarction) patients who  underwent intracoronary injection of prourokinase by balloon catheter. MethodsA total of 135 STEMI patients who underwent primary PCI were enrolled and  depending on whether use of prourokinase they were randomly  divided into two groups，test group (prourok inase group， n=66) and control group (n=69).The test group got injected prourokinase 10 mg (10 ml) by expanding the balloon at the occlusion， the control group received the same dose of saline. The basic clinical data， corrected TIMI frame count (cTFC)， myocardial tissue perfusion grading (TMPG)， ST resolution ≥50% at 2 hours，wall motion score and score index after seven days and left ventricular ejection fraction (LVEF) on day 7 and 30 were recorded and analyzed. ResultsThe basic clinical data between two groups had no significant differences (P>0.05). cTFC，TMPG， ST resolution ≥50% at 2 hours， wall motion score and wall motion score index， LVEF on day 7 and 30 had significant differences between two groups (P<0.05).ConclusionIntracoronary administration of prourokinase through balloon castheter could improve myocardium perfusionin STEMI patients who underwent emergency PCI.

Key words: myocardial infarction, catheter, prourokinase, corrected TIMI frame count, myocardial tissue perfusion grading