Effect of salvianolate on serum levels of hs-CRP and TNF-α in unstable angina patients

doi:10.3969/j.issn.1004-583X.2016.02.013

Abstract

Abstract: Objective To observe the effect of salvianolate on plasma high-sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor( TNF-α) in unstable angina(UA) patients.Methods Ninety-six UA patients were divided into two groups. Control group of 48 cases received conventional western medicine treatment,48 cases in the treatment group received salvianolate on the basis of control group treatment. Two weeks was as a period of treatment. The therapeutic effect was evaluated after two courses. The level of hs-CRP and TNF-α in two groups were detected before and 1 week,2 weeks after treatment.Results Before treatment,hs-CRP and TNF-α levels between two groups had no statistically significant (P>0.05). After treatment for 1 week and 2 weeks hs-CRP in observation group was (12.5±2.2) mg/L and (5.2±1.1) mg/L respectively, while that in the control group was (15.3±2.8) mg/L and (8.5±1.5) mg/L. There was the significant difference between two group (P<0.05); Moreover, TNF-α in observation group was significantly lower than that in control group (P<0.05). The efficacy in observation group was 93.8% (45/48), that in control group was 77.1% (37/48).The observation group was significantly higher than the control group (P<0.05).Conclusion Salvianolate combined treatment might improve the clinical symptoms of UA patients by decreasing hs-CRP and TNF-α.

Key words: angina, unstable, C-reactive protein, tumor necrosis factor-alpha, salvia miltiorrhiza

CLC Number:

R541.4

Mao Yanyang,Wang Junqiang,Wang Chenxia,Wang Congxia. Effect of salvianolate on serum levels of hs-CRP and TNF-α in unstable angina patients[J]. Clinical Focus, 2016, 31(2): 191-193.

Add to citation manager EndNote|Ris|BibTeX

URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.02.013

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I2/191

References

[1] Halladin NL, Ekelf S, Jensen SE, et al. Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction[J]. In Vivo, 2014, 28(4): 483-488.
[2] 励峰,任贤,徐向阳,等.丹参多酚酸盐保护体外循环后心脏功能的研究[J].中华老年心脑血管病杂志,2013,15(2):178-182.
[3] Liu L, Li J, Zhang Y, et al. Salvianolic acid B inhibits platelets as a P2Y 12 antagonist and PDE inhibitor: evidence from clinic to laboratory[J]. Thromb Res, 2014, 134(4): 866-876.
[4] Zhao K, Lin Y, Li YJ, et al. Efficacy of short-term cordyceps sinensis for prevention of contrast-induced nephropathy in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention[J]. Int J Clin Exp Med, 2014, 7(12): 5758.
[5] 田玉龙,邢玉良,葛中春,等.负荷量加高维持量阿托伐他汀对ACS患者介入治疗后血管内皮功能、血小板活化及炎性因子的影响[J].海南医学院学报,2015,21(2):212-214,217.
[6] 李树仁,王天红,张宝军,等.脑心通胶囊对冠状动脉临界病变冠心病患者炎症反应及预后的影响[J].中国中西医结合杂志,2012,32(5):607-611.
[7] Dubey L, Sharma SK, Gautam S, et al. Takotsubo cardiomyopathy mimicking acute ST-segment elevation myocardial infarction in a 28-year-old woman[J]. Adv Intern Med, 2014, 3(1): 38-41.
[8] 江宗朋,季祥武,张爱元,等.丹参多酚酸盐治疗不稳定型心绞痛的疗效及其对AngⅡ、UA、VEGF的影响[J].山东医药,2012,52(13):25-27.
[9] Yao HC, Zhao AP, Han QF, et al. Correlation between serum high-mobility group box1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease[J]. Exp Ther Med, 2013, 6(1): 121-124.
[10] 韦凌云,杨丕坚,李舒敏,等.丹参多酚酸盐对糖尿病周围神经病变患者炎性细胞因子及血管内皮功能的影响[J].中华实用诊断与治疗杂志,2014,28(3):303-305.
[11] 印章.替米沙坦对不稳定型心绞痛患者内皮祖细胞和高敏C反应蛋白的作用[J].临床荟萃,2013,28(8):858-860.
[12] 唐召力,覃碧云,滕秋叶,等.丹参多酚酸盐与丹参注射液对不稳定型心绞痛氧化修饰低密度脂蛋白、血友病因子和超敏C反应蛋白的作用比较[J].临床荟萃,2012,27(17):1495-1497.
[13] Savic-Radojevic A, Radovanovic S, Pekmezovic T, et al. The role of serum VCAM-1 and TNF-α as predictors of mortality and morbidity in patients with chronic heart failure[J]. J Clin Lab Anal, 2013, 27(2): 105-112.
[14] 陆卫华,方庆,龚志刚,等.急性冠状动脉综合征患者血清炎性因子的相关性研究[J].重庆医学,2013,42(7):744-745,748.
[15] Meng S, Wang LS, Huang ZQ, et al. Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention[J]. Clin Exp Pharmacol Physiol, 2012, 39(5): 406-411.
[16] Wang X, Zhang C, Yang R, et al. Clinical study of the hypothesis of “endogenous collateral wind” on acute coronary syndrome-a review[J]. Afr J Tradit Complement Altern Med, 2013, 11(1): 121-126.
[17] 张辉,张杨,杨蓉,等.丹参多酚酸盐对急性冠脉综合征患者炎症因子影响的相关研究[J].中国中西医结合杂志,2013,33(5):598-601.
[18] 洪娅丽,魏武杰,邓宁,等.丹参多酚酸盐联合曲美他嗪治疗不稳定型心绞痛疗效观察[J].湖北中医药大学学报,2014,16(3):18-20.
[19] Redfors B, Rmunddal T, Shao Y, et al. Takotsubo triggered by acute myocardial infarction: a common but overlooked syndrome?[J]. J Geriatr Cardiol, 2014, 11(2): 171.
[20] 邱雅慧,薛凌,高夏青,等.丹参多酚酸盐对慢性心力衰竭患者心功能及炎症因子的影响[J].中国实验方剂学杂志,2013,19(7):321-323.
[21] 徐蓉,邱凌,汪思阳,等.丹参多酚酸盐治疗老年不稳定型心绞痛患者的临床疗效评价[J].中国老年学杂志,2011,31(23):4672-4673.
[22] Liu C, Hou Y, Wang X, et al. Clinical assessment of Shenfu injection loading in the treatment of patients with exacerbation of chronic heart failure due to coronary heart disease: study protocol for a randomized controlled trial[J]. Trials, 2015, 16(1): 222.