Relationship between serum homocysteine,hs-CRP and acute coronary syndrome in young and middle age patients

doi:10.3969/j.issn.1004-583X.2016.02.014

Abstract

Abstract: Objective To investigate the correlation of serum homocysteine,high sensitive C reactive protein(hs-CRP) and acute coronary syndrome(ACS) in young and middle aged patients.Methods A total of 142 in young and middle age ACS patients who received coronary angiography and hospitalized in Tianjin Chest Hospital were included. The patients were divided into two groups, acute myocardial infarction(AMI) group (n=61),and unstable angina (UAP) group (n=81). A normal control group was selected (n=60). Serum homocysteine,hs-CRP were tested for all subjects. The correlation of serum homocysteine,hs-CRP and ACS were analyzed.Results Serum homocysteine and hs-CRP in AMI group were significantly different from those of normal control and UAP group (P<0.05).There were no significant differences between UA group and normal control group. Serum homocysteine and hs-CRP were both significantly correlated with Gensini score (r=0.17,0.26,P<0.05). Logistic analysis indicated the relationship between homocysteine and ACS.Conclusion Serum homocysteine and hs-CRP correlates significantly with ACS in young and middle age patients.They can provide reference value for the evaluation of coronary artery disease.

Key words: acute coronary syndrome, cysteine, C-reactive protein, young and middle-aged

CLC Number:

R542.2

Du Huiqi, Qin Qin, Li Yang. Relationship between serum homocysteine,hs-CRP and acute coronary syndrome in young and middle age patients[J]. Clinical Focus, 2016, 31(2): 194-197.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.02.014

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I2/194

References

[1] 钟琳玲,廖芳. 血清同型半胱氨酸与冠心病的相关性研究[J].实用心脑肺血管病杂志,2011,19(10):31-32.
[2] 高阅春,李全,何继强,等.超敏C 反应蛋白水平与冠心病严重程度及预后的相关性研究[J].中国全科医学,2012,15(8): 840-843.
[3] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J]. 中华心血管病杂志,2011,39(5):701-708.
[4] Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease.[J]. Am J Cardi, 1983, 51(3):606.
[5] 黄斌,李星阳,潘凤霞,等.急性冠状动脉综合症患者血清同型半胱氨酸水平与冠状动脉病变程度的关系[J].中西医结合心血管病杂志,2015,3(9): 138-139.
[6] Stankovic S. Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factors[J]. Crit Rev Clin Lab Sci,2010,47(2):72-123.
[7] 谢志娟,谭小进,王金林. 中青年人急性心肌梗塞危险因素的探讨及叶酸对同型半胱氨酸水平的影响[J].西部医学,2008,20(2):317-319.
[8] 杨文,张艳华,沙春蕊. 老年冠心病患者血浆同型半胱氨酸和C－反应蛋白水平的变化及临床意义[J].吉林大学学报:医学版,2009,35(6):1115-1118.
[9] 李建华,杨文东,王其国. 血清氧化型低密度脂蛋白及同型半胱氨酸水平与冠状动脉病变严重程度的相关性研究[J].实用心脑肺血管病杂志,2012,20(2): 227-228.
[10] 叶涛.同型半胱氨酸与心血管疾病的研究进展[J].实用心脑肺血管病杂志,2012,20(6): 944-945.
[11] 张俊英,韩卉芳,关艳丽.高同型半胱氨酸血症与冠心病相关性探讨[J].中国药物与临床,2014,(08):12-15.
[12] 伍继初,闾宏伟.冠心病患者血清同型半胱氨酸水平与冠状动脉病变程度的相关性[J]中国医药导刊,2014,(01):136.
[13] 朱德才,王申,等.超敏C－反应蛋白与心脑血管疾病的研究进展[J].临床急诊杂志,2013,14(10):503-506.
[14] 李莲.hs-CRP 与急性冠状动脉综合征的关系研究[J].中国现代医生,2015,53(20):8-10.
[15] Szalai AJ, Mccrory MA, Xing D, et al. Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models[J]. Mediators Inflamm, 2014, 2014(1):353614-353614.
[16] 陈洁.血清尿酸、hs-CRP 水平与冠状动脉病变严重程度的关系分析[J].当代医学,2015,21(21):12-13.
[17] Kettunen T,Eklund C,Kahonen M,et al.Polymorphism in the C-reactive(CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: the Health 2000 Survey[J]. Scand J Clin Lab Invesst,2011,71(5):353-361.
[18] 涂昌,兰军,陈本发,等. 血浆Hcy 和hs-CRP与心绞痛患者冠状动脉病变的关系[J].中华全科医学,2011,10(11):1670-1671.
[19] 钟静敏,许庆波,叶海鹏,等.H型高血压与冠状动脉病变的关系研究[J].实用心脑肺血管病杂志,2013,21(5):34-35.
[20] Kamiński KA,Tycińska AM,Stepek T,et al. Natural history and risk factors of long-term mortality in acute coronary syndrome patients with cardiogenic shock[J]. Adv Med Sci,2014,59(2):1123-1124.