Abstract: Objective  To investigate the clinical and neuroimaging features in patients with corpus callosum infarction who presented psychiatric and affective symptoms. Methods Patients with corpus callosum infarction were examined with neuropsychiatric inventory， hamilton anxiety scale and hamilton depression rating scale for depression. All patients were performed with cranial magnetic resonance imaging.Results The study included seven patients who presented psychiatric and affective symptoms. The infarction location of two patients lied in the genu part of corpus callosum， two patients in the genu and body parts of corpus callosum， two patients in the body part of corpus callosum and one patient in the body and splenium of corpus callosum. Three patients showed abnormal behaviors， four patients showed irritability， two patients showed agitation， two patients showed delusion and one patient showed hallucination. Conclusion Corpus callosum infarction should be taken into consideration in patients with risk factors of cerebral vascular diseases who presented acute psychiatric and affective symptoms， cranial magnetic resonance imaging should be early performed to avoid delay in treatment.

Key words: brain , infarction, corpus callosum, psychiatri, affective symptoms