Abstract: ObjectiveTo investigate the correlation of tumor necrosis factor α(TNFα)， high sense Creactive protein(hsCRP)， lower density lipoprotein cholesterol C(LDLC) with acute cerebral infarction(ACI) in elderly patients. MethodsSeventyfive cases of elderly patients with ACI were collected in our hospital， 40 elderly healthy people  in our hospital served as the controls from health check at the same time，  the differences of biochemical indicators were compared between two groups. Analysis was made in the relationship between clinical features and TNFα， hsCRP， LDLC levels， and the correlation analysis of TNFα， hsCRP and LDLC levels in acute cerebral infarction patients. ResultsThe TC， TG， LDLC， hsCRP and TNFα in ACI group were higher than those in control group (P<0.05). LDLC， hsCRP， TNFα in patients with ACI increased with BMI and the disease degree and IMT(P<0.05); LDLC and hsCRP  positively correlated (0.424，P<0.01)， LDLC and TNFα showed positive correlation (r=0.352，P=0.002)，hsCRP and TNFα  positively related (r=0.480，P<0.01). ConclusionTNFα，hsCRP and LDLC in elderly patients with ACI were abnormally higher， and correlated with the degree of disease， and they could be used as  important indexes in evaluation of the occurrence and development of the patients' condition.

Key words: brain infarction, tumor necrosis factoralpha, Creactive protein；cholesterol, LDL