Abstract: Objective  To investigate the effect of single loading dose and conventional dose of rosuvastatin on the prognosis of patients with coronary heart disease before and after percutaneous coronary intervention (PCI). Methods  Totally 108 patients who underwent PCI intervention in our hospital were randomly divided into conventional group (n=54,  rosuvastatin 5 mg at 12 h preoperatively) and loading group (n=54,  rosuvastatin 20 mg at 12 h preoperatively). After operation,  all patients in two groups took contineously the conventional dose of rosuvastatin 5 mg. Basic clinical indexes,  myocardial basic indicators and followup for the whole patients were detected before and after PCI. Meanwhile,  changes in each index,  major adverse cardiovascular events (MACE),  hepatotoxicity and myotoxicity of rosuvastatin were observed and compared. Incidence of MACE,  hepatotoxicity and myotoxicity of rosuvastatin were compared respectively. Results  The levels of myocardial markers,  cardiac troponin T(cTnT),  monocyte chemotactic protein1(MCP1), C reactive protein (CRP) and creatine kinase (CKMB) at 24 h and 7 d postoperatively rose as compared with those before PCI,  indicating statistically significant differences bewteen conventional group and loading group (P<0.05); Followup of MACE,  hepatotoxicity and myotoxicity of rosuvastatin within 30 d and 1 year postoperatively were recorded and revealed statistically significant differences (P<0.05). Conclusion  The single loading dose of rosuvastatin before PCI is of positive significance for the prognosis of patients with coronary heart disease. Moreover,  application of loading dose of statins before operation can reduce postoperative adverse cardiac events.

Key words: coronary disease, angioplasty, , transluminal, , percutaneous coronary, prognosis