Abstract:

Objective To explore the correlation of serum high-sensitivity C-reactive protein (hs-CRP), urine microalbumin (U-mAlb)/ creatinine (Cr) and diabetic retinopathy (DR), and the risk factors of proliferative diabetic retinopathy (PDR). Methods Totally 150 patients with type 2 diabetes mellitus (T2DM) were divided into three groups: non DR group (NDR group, n=67), non PDR group (NPDR group, n=55) and PDR group (n=28). The subjects were detected the level of fasting venous blood glucose (FPG), glycosylated hemoglobin (HbA₁c), hs-CRP and U-mAlb/Cr; the variation of hs-CRP and U-mAlb/Cr in different stages of DR as well as the risk factors associated with PDR were analyzed. Results The levels of hs-CRP and U-mAlb/C rised gradually among the three groups, which in PDR group were most prevalent, following by NPDR group (P<0.05). Spearman correlation analysis showed that the levels of hs-CRP and U-mAlb/Cr were significantly positively correlated with the severity of DR (P<0.05). Logistic regression analysis indicated that the risk factors for PDR were hs-CRP, U-mAlb/Cr and DR disease duration (P<0.05). Conclusion The detection of hs-CRP and U-mAlb/Cr should be emphasize in the diagnosis and treatment of DR, because the high expression of which are significantly positively correlated with the severity of DR.

Key words: diabetic retinopathy, high sensitivity c-reactive protein, urine microalbumin, creatinine