Abstract: Objective  To compare the difference of glucose variability between people with type 2 diabetic retinopathy and those without retinopathy in order to explore the relationship between glucose variability and type 2 diabetic retinopathy.Methods  A total of 17 studies were included to compare the glucose variability of patients with type 2 diabetic retinopathy and those without retinopathy by searching database comprehensively.RevMan5.3 software and  STATA12.0 software were adopted for the meta analysis.Results  Among the 17 studies, mean amplitude of glycemic excursion(MAGE) of the diabetic retinopathy（DR）   group was significantly higher than that of the nondiabetic retinopathy(NDR)  group (weighted mean difference［WMD］ and 95%CI  2.12［1.66, 2.58］, P<0.01). Of the 9 included studies,  the MAGE  of the nonproliferative diabetic retinopathy (NPDR) group was significantly lower than that of the proliferative diabetic retinopathy (PDR) group(WMD and 95%CI  -1.09［-1.42，-0.77］, P<0.01).  Compared with the NDR group, MAGE were significantly higher in the NPDR group (WMD and 95%CI   1.52［1.25,  1.79］, P<0.01). Conclusion  From diabetic nonretinopathy group, nonproliferative retinopathy group to proliferative retinopathy group, the glucose variability presents a gradually increasing trend.

Key words: diabetes mellitus, , type 2；glucose variability；diabetic retinopathy, meta , analysis