Application of vericiguat in elderly patients with heart failure with reduced ejection fraction

doi:10.3969/j.issn.1004-583X.2024.12.003

Abstract

Abstract:

Objective To evaluate the efficacy and safety of vericiguat in the treatment of heart failure with reduced ejection fraction (HFrEF) in elderly patients. Methods A total of 46 HFrEFpatients older than 75 years treated in our hospital from January 2023 to August 2024 were retrospectively recruited for analyses. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), serum potassium (K⁺), creatinine (Cr), N-terminal B-type natriuretic peptide precursor (NT-proBNP), six-minute walking test (6MWT) and the Kansas City Cardiomyopathy Questionnaire (KCCQ) scores before and 3 months after treatment were compared. Results There were no significant differences in SBP, DBP, HR, K⁺ and Cr between the two groups after 3 months of treatment (P>0.05). NT-proBNP, 6MWT and KCCQ after 3 months of treatment were significantly improved by the treatment of vericiguat (P<0.05). Conclusion Vericiguat has little effects on SBP, DBP, HR, K⁺ and renal function in elderly patients with HFrEF, but improve cardiac function and quality of life.

Key words: heart failure, vericiguat, aged, quality of life

CLC Number:

R541.6

Wang Ting, Chai Chunyan. Application of vericiguat in elderly patients with heart failure with reduced ejection fraction[J]. Clinical Focus, 2024, 39(12): 1081-1084.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.12.003

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I12/1081

Figures/Tables 3

Tab. 1 Baseline data

临床资料	数据
年龄(岁)	80.6±4.13
男性[例(%)]	26(56.5)
体质量指数(kg/m²)	19.09±2.37
左心室射血分数(%)	36.37±6.86
纽约心功能分级[例(%)]
Ⅱ	0
Ⅲ	35(76.1)
Ⅳ	11(23.9)
基础疾病[例(%)]
2型糖尿病	23(50.0)
高血压	16(34.8)
房颤	27(58.7)
冠心病	25(54.3)
慢性肾功能不全	38(67.8)
服药情况[例(%)]
螺内酯	37(80.4)
β受体阻滞剂	36(78.3)
ARNI/ACEI/ARB	29(63.0)
SGLT2i	16(34.8)
噻嗪利尿剂	46(100.0)
伊伐布雷定	9(19.6)
服用5种以上药物[例(%)]	35(76.1)
服用10种以上药物[例(%)]	27(58.7)

Tab. 2 Comparison of SBP, DBP, HR, K+, Cr before and after treatment

时间	SBP(mmHg)	DBP(mmHg)	HR(次/min)	K⁺(mmol/L)	Cr(umol/L)
治疗前	112.33±9.13	63.23±7.83	68.80±8.12	4.48±0.51	112.43±47.58
治疗后	110.80±8.13	62.67±5.17	66.70±7.09	4.44±0.32	114.54±53.11
$t$ 值	0.813	0.902	1.103	0.475	-0.613
P值	0.421	0.296	0.263	0.657	0.552

Tab. 2 Comparison of SBP, DBP, HR, K+, Cr before and after treatment

时间	SBP(mmHg)	DBP(mmHg)	HR(次/min)	K⁺(mmol/L)	Cr(umol/L)
治疗前	112.33±9.13	63.23±7.83	68.80±8.12	4.48±0.51	112.43±47.58
治疗后	110.80±8.13	62.67±5.17	66.70±7.09	4.44±0.32	114.54±53.11
$t$ 值	0.813	0.902	1.103	0.475	-0.613
P值	0.421	0.296	0.263	0.657	0.552

Tab. 3 Comparison of NT-proBNP, 6MWT and KCCQ score before and after treatment with vericiguat

时间	NT-proBNP(pg/ml)	6MWT(m)	KCCQ得分(分)
治疗前	5456.07±2941.23	180.37±83.57	59.30±12.44
治疗后	3955.63±1770.18	236.31±96.12	65.56±11.23
$t$ 值	6.484	-10.201	-29.513
P值	0.000	0.000	0.000

Tab. 3 Comparison of NT-proBNP, 6MWT and KCCQ score before and after treatment with vericiguat

时间	NT-proBNP(pg/ml)	6MWT(m)	KCCQ得分(分)
治疗前	5456.07±2941.23	180.37±83.57	59.30±12.44
治疗后	3955.63±1770.18	236.31±96.12	65.56±11.23
$t$ 值	6.484	-10.201	-29.513
P值	0.000	0.000	0.000

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