Correlation between systemic immune inflammation index and multivessel coronary disease in patients with acute coronary syndrome

doi:10.3969/j.issn.1004-583X.2024.06.005

Abstract

Abstract:

Objective To investigate the correlation between systemic immune inflammation (SII) index and severity of coronary artery disease in patients with acute coronary syndrome (ACS). Methods A total of 206 ACS patients with typical symptoms of chest pain and chest tightness underwent coronary angiography in the Department of Cardiology of Anshan Central Hospital from September 2021 to March 2023 were enrolled. The clinical data and the immune inflammation indexes were assessed. According to the coronary angiography results or the modified Gensini score, the patients were divided into single-vessel disease group (n=51) and multi-vessel disease group (n=155), or mild lesion group (n=89) and advanced lesion group (n=117). The inter-group differences in clinical data were compared, and the independent risk factors for severity of coronary artery disease were screened for evaluating their predictive value. Results The area under the curve of SII in predicting severity of coronary artery disease in ACS patients was 0.93. When SII was 631.31, the predictive ability for severity of coronary artery disease in ACS patients was the highest, with 81.9% of the sensitivity and 96.1% of specificity. Conclusion SII is an independent risk factor for severity of coronary artery disease in ACS patients, and it has a high predictive value.

Key words: acute coronary syndrome, systemic immune inflammation index, multiple vessel lesions, moderate to severe lesions

CLC Number:

R541.4

Wang Zhongqi, Li Jinzhao, Wu Nan. Correlation between systemic immune inflammation index and multivessel coronary disease in patients with acute coronary syndrome[J]. Clinical Focus, 2024, 39(6): 512-517.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.06.005

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I6/512

Figures/Tables 5

References 25

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项目	单支病变组(n=51)	多支病变组(n=155)	χ²/t/Z值	P值
年龄(岁)	59±10	63±11	-2.477	0.014
男性[例(%)]	36(70.6)	105(67.7)	0.311	0.577
高血压[例(%)]	16(31.4)	131(84.5)	65.592	<0.01
糖尿病[例(%)]	6(11.8)	47(30.3)	8.623	0.003
吸烟[例(%)]	18(35.3)	59(38.1)	0.694	0.405
饮酒[例(%)]	2(3.9)	12(7.7)	1.183	0.277
BMI(kg/m²)	25.70±0.66	24.94±0.27	-0.557	0.578
TG(mmol/L)	1.8(1.39,2.27)	1.69(1.22,2.54)	-0.842	0.400
TC(mmol/L)	5.49±1.09	5.35±1.26	0.723	0.470
HDL-C(mmol/L)	1.01(0.88,1.16)	1.01(0.84,1.24)	-0.367	0.714
LDL-C(mmol/L)	3.59(2.75,4.25)	3.46(2.96,4.1)	-0.179	0.858
CRP(mg/L)	2.43(0.67,6.24)	4.14(1.5,5.02)	2.149	0.032
WBC(×10⁹/L)	6.07(5.52,7.14)	8.61(7.47,10.2)	8.411	<0.01
NEU(×10⁹/L)	3.65(3.1,4.19)	6.08(4.93,7.55)	8.801	<0.01
MON(×10⁹/L)	0.46(0.37,0.59)	0.81(0.64,1.03)	7.741	<0.01
LYM(×10⁹/L)	1.69(1.56,2.04)	1.49(1.32,1.74)	-4.893	<0.01
PLT(×10⁹/L)	187(168,201)	227(205,253)	7.749	<0.01
NLR(×10⁹/L)	2.06(1.72,2.5)	4.13(3.16,5.04)	8.659	<0.01
MLR(×10⁹/L)	0.27(0.2,0.33)	0.56(0.42,0.7)	7.811	<0.01
PLR(×10⁹/L)	104.27(88.73,120)	154.29(131.94,183.56)	7.583	<0.01
SII(×10⁹/L)	371.9(320.2,460.34)	964.5(721.73,1227.71)	9.136	<0.01

项目	单支病变组(n=51)	多支病变组(n=155)	χ²/t/Z值	P值
年龄(岁)	59±10	63±11	-2.477	0.014
男性[例(%)]	36(70.6)	105(67.7)	0.311	0.577
高血压[例(%)]	16(31.4)	131(84.5)	65.592	<0.01
糖尿病[例(%)]	6(11.8)	47(30.3)	8.623	0.003
吸烟[例(%)]	18(35.3)	59(38.1)	0.694	0.405
饮酒[例(%)]	2(3.9)	12(7.7)	1.183	0.277
BMI(kg/m²)	25.70±0.66	24.94±0.27	-0.557	0.578
TG(mmol/L)	1.8(1.39,2.27)	1.69(1.22,2.54)	-0.842	0.400
TC(mmol/L)	5.49±1.09	5.35±1.26	0.723	0.470
HDL-C(mmol/L)	1.01(0.88,1.16)	1.01(0.84,1.24)	-0.367	0.714
LDL-C(mmol/L)	3.59(2.75,4.25)	3.46(2.96,4.1)	-0.179	0.858
CRP(mg/L)	2.43(0.67,6.24)	4.14(1.5,5.02)	2.149	0.032
WBC(×10⁹/L)	6.07(5.52,7.14)	8.61(7.47,10.2)	8.411	<0.01
NEU(×10⁹/L)	3.65(3.1,4.19)	6.08(4.93,7.55)	8.801	<0.01
MON(×10⁹/L)	0.46(0.37,0.59)	0.81(0.64,1.03)	7.741	<0.01
LYM(×10⁹/L)	1.69(1.56,2.04)	1.49(1.32,1.74)	-4.893	<0.01
PLT(×10⁹/L)	187(168,201)	227(205,253)	7.749	<0.01
NLR(×10⁹/L)	2.06(1.72,2.5)	4.13(3.16,5.04)	8.659	<0.01
MLR(×10⁹/L)	0.27(0.2,0.33)	0.56(0.42,0.7)	7.811	<0.01
PLR(×10⁹/L)	104.27(88.73,120)	154.29(131.94,183.56)	7.583	<0.01
SII(×10⁹/L)	371.9(320.2,460.34)	964.5(721.73,1227.71)	9.136	<0.01

因素	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
因素	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
CRP	-0.052	0.051	1.057	0.304	0.949	0.860	1.048
NEU	2.489	1.118	4.959	0.026	12.043	1.347	107.645
MON	18.864	6.652	8.042	0.005	0.280	0.128	0.609
LYM	-3.090	1.967	2.468	0.116	0.046	0.001	2.149
PLT	0.103	0.040	6.585	0.010	1.108	1.025	1.199
NLR	4.912	2.435	4.070	0.044	0.938	0.835	1.054
MLR	-20.057	8.961	5.010	0.025	0.000	0.000	0.083
PLR	0.081	0.056	2.133	0.144	1.085	0.973	1.209
SII	-0.033	0.009	14.074	<0.01	0.968	0.952	0.985

因素	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
因素	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
CRP	-0.052	0.051	1.057	0.304	0.949	0.860	1.048
NEU	2.489	1.118	4.959	0.026	12.043	1.347	107.645
MON	18.864	6.652	8.042	0.005	0.280	0.128	0.609
LYM	-3.090	1.967	2.468	0.116	0.046	0.001	2.149
PLT	0.103	0.040	6.585	0.010	1.108	1.025	1.199
NLR	4.912	2.435	4.070	0.044	0.938	0.835	1.054
MLR	-20.057	8.961	5.010	0.025	0.000	0.000	0.083
PLR	0.081	0.056	2.133	0.144	1.085	0.973	1.209
SII	-0.033	0.009	14.074	<0.01	0.968	0.952	0.985

项目	轻度病变组(n=89)	中重度病变组(n=117)	χ²/t/Z值	P值
年龄(岁)	59±10	64±11	-3.311	0.001
男性[例(%)]	62(69.7)	79(67.5)	0.107	0.743
高血压[例(%)]	43(48.3)	104(88.9)	40.717	<0.01
糖尿病[例(%)]	10(11.2)	43(36.8)	17.227	<0.01
吸烟[例(%)]	31(34.8)	46(39.3)	0.434	0.510
饮酒[例(%)]	3(3.4)	11(9.4)	2.903	0.088
BMI(kg/m²)	24.8(22.9, 28)	24.7(22.4, 27.1)	-0.691	0.489
TC(mmol/L)	5.52±1.19	5.3±1.24	1.344	0.180
TG(mmol/L)	1.85(1.37,2.65)	1.65(1.22,2.4)	-1.496	0.249
HDL-C(mmol/L)	1.08(0.87,1.26)	0.99(0.85,1.21)	-1.206	0.228
LDL-C(mmol/L)	3.54(2.87,4.26)	3.46(2.94,4.08)	-0.433	0.665
CRP(mg/L)	2.47(0.8,4.55)	5.27(1.61,8.95)	3.613	<0.01
WBC(×10⁹/L)	6.7(5.91,7.76)	9.03(7.85,10.51)	8.129	<0.01
NEU(×10⁹/L)	4.08(3.42,5.04)	6.38(5.29,7.87)	8.939	<0.01
MON(×10⁹/L)	0.54(0.41,0.69)	0.87(0.69,1.14)	8.575	<0.01
LYM(×10⁹/L)	1.74(1.54,2.04)	1.41(1.29,1.58)	-7.208	<0.01
PLT(×10⁹/L)	195(182.5,211)	234(213,267)	8.320	<0.01
NLR(×10⁹/L)	2.33(1.93,2.87)	4.52(3.78,5.41)	10.291	<0.01
MLR(×10⁹/L)	0.28(0.22,0.39)	0.61(0.49,0.79)	9.764	<0.01
PLR(×10⁹/L)	112.43(92.59,130.19)	165.15(144.45,201)	9.774	<0.01
SII(×10⁹/L)	441.76(355.61,549.66)	1074.29(859.28,1346.5)	10.763	<0.01