Abstract:

ObjectiveTo investigate the significance of adiponectin and visfatin joint monitoring in predicting heart failure after PCI in acute myocardial infarction. MethodsA total of 157 cases of AMI patients undergoing PCI were selected. According to whether heart failure happened after PCI， the patients were divided into occurrence group (n=62) and nonoccurrence group (n=95). Forty cases of healthy were selected as control group. The echocardiography and blood biochemical examination data of all subjects were collected. In all AMI patients after PCI the next day and the control group in medical examination day， the serum levels of visfatin and APN were detected by using automated enzymelinked fluorescence analyzer. ResultsThe LVDs in occurrence group was greater than that in nonoccurrence group and control group， while LVEF was less than that of nonoccurrence group and control group(P<0.05). LDLC， CKMB， cTnI， NTproBNP， CRP， WBC and NE in occurrence group and nonoccurrence group were higher than those in control group， and  CKMB， cTnI and NTproBNP in occurrence group were higher than those in nonoccurrence group(P<0.05). The levels of APN in occurrence group and nonoccurrence group were lower than that of control group， while the levels of visfatin were higher than that of control group(P<0.05)， the level of APN in occurrence group was lower than that of nonoccurrence group， while the level of visfatin was higher than that of nonoccurrence group(P<0.05). Pearson correlation analysis showed that serum APN level in occurrence group was negatively correlated with TC， LDLC， CKMB， cTnI， CRP and NE (P<0.05)， and serum visfatin level was positively correlated with  TC， LDLC， CKMB， cTnI， NTproBNP， NE and LVDs (P<0.05). ROC curve showed that  the serum APN level in AMI patients after PCI can predict the occurrence of heart failure APN<13.67  g/L，the sensitivity was 64.2%， specificity  87.1%. Visfatin>6.29  mg/L， serum visfatin level showed the  sensitivity  90.3%， specificity  77.9%. ConclusionThe serum level of APN in AMI patients after PCI was reduced， while visfatin was elevated. They could be as indicators to predict heart failure occurring after PCI.

Key words: myocardial infarction, angioplasty, transluminal, percutaneous coronary, adiponectin, visfatin, heart failure, congestive