Abstract: Objective  To observe the characteristics of type 2 diabetes mellitus patients with primary liver cancer by ultrasonic method and analyze risk factors. Methods  Eightyfive cases of type 2 diabetes mellitus patients with primary liver cancer were observed with color Doppler characteristics. A total of 87 patients with type 2 diabetes mellitus patients without any cancer who did the same examination at the same period were assigned as the control group. The risk factors were analyzed by multivariate analysis. Results  Ultrasonographic features of liver lesions in 85 patients with T2DM complicated with primary liver cancer: the right of the liver was mainly monotonous. Most of the lumps grew regularly and had clear boundary. The echo image inside of lumps was mostly hypoechoic and the size of lumps ranged between 3 to 5 cm. The liver right lobe was the main one， the shape was regular and the boundary was clear. The echo of the lesion was mainly hypoechoic， and the size of the lesion was between 35  cm. Doppler ultrasonic results: lesions within and around the blood flow were mostly Ⅲ class， showing highspeed and highresistance blood flow spectrum. The logisitic regression analysis showed that gender， age， drinking， HbA1C and HbsAg (+) were independent risk factors. Conclusion  The two dimensional and Doppler ultrasonic characteristics are valuable for diagnosis of the type 2 diabetes mellitus patients with liver cancer.  Male， age， drinking， HbA1c and chronic hepatitis B are independent risking factors in type 2 diabetes mellitus patients with prtmary  liver cancer.

Key words: diabetes mellitus, type 2, liver neoplasms, ultrasonography characteristics, risk factors