Abstract: Objective  To compare the curative effect of CAG regimen and CAG combined with decitabine regimen in elderly patients with acute myeloid leukemia(AML). Methods  Seventysix de novo elderly patients with AML who were diagnosed in our hospital were analyzed by a retrospective analysis. The 76 cases were divided into groups with CAG group and CAG+DAC group according to different chemotherapies.  We compared the differences of complete remission rate， overall response rate， median overall survival and median relapsefree survival in two groups. Results  CAG group of 49 cases：CR rate was 51.0%， ORR was 61.2%; CAG+DAC group of 27 cases: CR rate was 59.3%， ORR was 77.8%. The statistics analysis showed  no significant differences in CR rate and ORR between two groups(P>0.05). There were differences in median OS (10.0 months vs 12.0 months) and median RFS (8.0 months vs 11.0  months ) in  two groups(P>0.05). But in the highrisk group of patients， CR rate and ORR of the CAG+DAC group  were  higher  than  those of CAG group，respectively (57.1% vs 15%; 71.4% vs 25%)， the difference was statistically significant(P<0.05). CAG+DAC group was better than CAG group in median OS and median RFS， respectively (6.0 months vs 10.0  months) and (4.0 months vs 7.0 months)(P>0.05). Conclusion  CAG regimen is similar with CAG+DAC regimen in the clinical curative effect， but CAG+DAC regimen is better in the elderly patients with AML with poor prognosis.

Key words: leukemia, myeloid; , decitabine, curative , effect