Abstract: Objective  To evaluate the epidemiological characteristics of PGN by analyzing the pathological types and clinical manifestations of patients receiving renal biopsy in recent years. Methods  The renal pathological data and clinical manifestation of patients receiving renal biopsy from August 2009 to April 2016 were collected. Patients were grouped according to the time of renal biopsy, gender and age in order to analyze the epidemiological characteristics of PGN. At the same time, the clinical manifestations of different pathological types were observed and the correlation between them were analyzed. Results  A total of 1 642 cases diagnosed as PGN by renal biopsy were enrolled in this study. Among them, MN was the most common pathological type, which had 556 cases and accounted for 33.86%. The majority of the patients was the middleaged and the elderly, and the incidence of the disease was increasing year by year. IgAN was the second pathological type and had 511 cases (31.12%).  Although it was still the main pathological type in the youth group, in middleaged and elderly patients, its incidence was inferior to MN, presenting a downward trend yearly. The clinical manifestations of patients with different pathological types were different. MN was mainly manifested as NS, while the main manifestation of IgAN was Pro and Hem. Conclusion  The disease spectrum of PGN has changed in recent years, and the acquisition of epidemiological data will help to analyze the causes and further clarify the possible pathogenic factors of glomerulonephritis.

Key words: glomerulonephritis, pathology, glomerulonephritis, , membranous, glmerulonephritis, , IGA