Abstract: Objective  To investigate the risks factors of left ventricular(LV) diastolic dysfunction (DD) in patients with chronic kidney disease (CKD).Methods  A  total of 120 patients with CKD  stage 35 and LV ejection fraction (EF)>50%  were  enrolled in this study.According to the results of peak early diastolic velocity (EmLV), patients were divided into LV diastolic dysfunction (DD+) group (EmLV<8 cm/s) (n=59) and normal LV diastolic dysfunction (DD-) group (EmLV≥8 cm/s) (n=61). Standard echocardiography and tissue Doppler echocardiography were  performed to evaluate the parameters related to LV diastolic function. The following laboratory parameters were detected: serum creatinine concentration, estimated glomerular filtration rate, urea, Ca, P, parathormone, platelet count, hemoglobin and Nterminal proBtype natriuretic peptide (NTproBNP). Results  Compared with DD(-) patients, the level of serum Ca was significantly decreased in DD(+) patients（P<0.01）. ROC curve derived Ca≤ 1.98 mmol/L was characterized by a sensitivity of  92.8% and specificity of 39.2% for diagnosing LV diastolic dysfunction. Moreover, multivariate logistic regression showed that serum Ca≤1.98  mmol/L  was the only variable predicting LV diastolic dysfunction.Conclusion  Hypocalcemia is the  independent predictive factor for LV diastolic dysfunction in patients with CKD.

Key words: kidney diseases；hypocalcemia, ventricular function, , left