Abstract: Objective  To study the safety and effectiveness of dexmedetomidine combined with propofol and sufentanil anesthesia in bronchoscopy and their clinical value. Methods  Sixty patients who accepted  bronchoscopic examination were randomly divided into two groups: DPS group（Dexmedetomidine combined with propofol and sufentanil group,  n=30, 1 μg/kg dexmedetomidine intravenous infusion for 10 minutes  and intravenous infusion of 0.1 μg/kg  sufentanil  for 5 minutes.)  and PS group (Propofol combined with sufentanil,  n=30, 0.25 ml/kg saline was infused intravenously for 10 minutes and intravenous infusion of  0.1  μg/kg  sufentanil  for 5 minutes before operation),  then propofol was used to induce and maintain anesthesia. Results  The MOAA/S score of DPS group was higher than that of PS group at T2 and T3 time points (P<0.05),  and it was lower than that of PS group at T4,  T5 and T6 time points (P<0.05); Ramsay score of DPS group was higher than that of PS group at T1 time point (P<0.05); HR of PS group was higher than that of DPS group at T5 and T6 time points (P<0.05). At T3,  T4 and T5 time points,  SpO2 was lower than DPS group (P<0.05); DBP and SBP of DPS group were lower than those of PS group at T5 and T6 time points (P<0.05); propofol consumption of DPS group was lower than that of PS group (P<0.05),  and anesthesia recovery time of DPS group was longer than PS group (P<0.05). The incidence of cough in DPS group was less than that in PS group (P<0.05),  but the incidence of hypotension was higher than that in PS group (P<0.05).  The satisfaction score of physicians of DPS group was higher than that in PS group. Conclusion  The anesthesia method of dexmedetomidine combined with propofol and sufentanil is safe and effective in painless flexible bronchoscopy,  which can provide stable hemodynamics and deep sedation for patients.

Key words: dexmedetomidine, propofol, bronchoscopy, hemodynamic phenomina, cough