Abstract: Objective  To investigate the clinical efficacy of Tianma Gouteng Decoction combined with irbesartan  in the treatment of essential hypertension. Methods  A total of 136 patients with essential hypertension admitted to our hospital from January 2018 to January 2020 were selected. They were randomly divided into observation group (68 cases) and control group (68 cases). The control group was treated with irbesartan tablets, and the observation group was treated with Tianma Gouteng Decoction combined with irbesartan tablets. Both groups were continuously treated for four weeks. The clinical efficacy and TCM symptom scores of two groups were analyzed, and the blood pressure, oxidative stress indicators and vascular endothelial injury marker levels of  two groups were compared before and after treatment. Results  After treatment, the TCM symptom scores of  observation group were significantly lower than those of  control group (P<0.01). The total clinical effective rate in observation group was higher than that in control group (P<0.05). After the treatment,  both systolic blood pressure and diastolic blood pressure in observation group were lower than those in control group (P<0.05). Compared with control group, observation group had lower serum AOPP and MDA, and higher serum SOD (P<0.05). And serum ET1, ICAM1 and vWF were significantly higher in observation group than those in control group, while serum NO in observation group was lower than that in control group(P<0.05). Conclusion   Tianma Gouteng Decoction combined with irbesartan  tablets in the treatment of essential hypertension is definitely effective, which can reduce vascular endothelial damage and help improve oxidative stress.

Key words: hypertension, drugs, Chinese herbal, treatment outcome