Abstract:

Objective To investigate the relations between the expression of cyclinD1, p27 and ultrasonographic features of central lymph node metastasis in the papillary thyroid microcarcinoma(PTMC). Methods Sixty patients with PTMC receiving central lymph node dissection in the hospital were selected, ultrasonographic features of all cases were recorded, and the expressions of cyclinD1 and p27 in thyroid tumor tissues were detected by immunohistochemical method. The patients were divided into two groups including the central lymph node metastasis group and central lymph node non-metastasis group based on results of postoperative pathological examinations, the relations between ultrasound features and central lymph node metastasis were analyzed, and relations between the expressions of CyclinD1 and P27 in central lymph node metastasis and ultrasound features were analyzed. Results In ultrasound features,the nodular boundary, calcification, aspect ratio ≥1 and multifocus in ultrasound features were related with central lymph node metastasis (P<0.05). High expression of CyclinD1 combined with low expression of p27 had a correlation with central lymph node metastasis (P<0.05).The patients with high expression of cyclinD1 were more likely to have unclear boundary of nodules, calcification or aspect ratio ≥1(P<0.05), and the patients with low expression of p27 are also prone to have the aspect ratio ≥1(P<0.05). Conclusion When nodules with unclear boundaries, calcification and high expression of cyclinD1 or when the aspect ratio ≥1 complicated with high expression of cyclinD1 or lower expression of p27, the possibility of central lymph node metastasis is high, hence, it is necessary to take prophylactic central lymph node dissection.

Key words: carcinoma, papillary, thyroid neoplasms, lymphatic metastasis, cyclind1