Correlation between vascular endothelial function and serum uric acid in gouty arthritis

doi:10.3969/j.issn.1004-583X.2023.03.008

Abstract

Abstract:

Objective To explore the effect of ultrasound (US) on the impairment of vascular endothelial function (VEF) in patients with gouty arthritis (GA) and its correlation with serum uric acid (SUA) levels.Methods This study included 45 GA patients (the GA group) and 35 healthy subjects (the control group). The key observation was laboratory data (SUA, high density lipoprotein [HDL], low-density lipoprotein [LDL], total cholesterol [TC], triglycerides [TG], C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]), height, weight, body mass index (BMI), disease duration. The right carotid intima media thickness (CIMT), flow-mediated dilation (FMD) of right upper limb were measured by US between GA group and control group. The correlation between FMD and SUA, other variables in the GA group was analyzed.Results Compared with the control group, BMI, SUA, ESR, CRP, TC, TG, LDL in the GA group were significantly increased, while FMD was significantly decreased (P<0.05). FMD was negatively correlated with SUA, CRP, CIMT and disease duration in GA group ( $r$ =-0.393, -0.322, -0.458, -0.431). Conclusion GA can cause damage to VEF in patients, which is related to SUA, CRP and the disease duration. US can evaluate VEF, which is of great value in the prevention of cardiovascular diseases.

Key words: gouty arthritis, vasodilation, uric acid, ultrasonic examination

CLC Number:

R684.3

Shen Xuejiao, Li Yan, Wang Ting, Wang Yuan. Correlation between vascular endothelial function and serum uric acid in gouty arthritis[J]. Clinical Focus, 2023, 38(3): 241-244.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.03.008

https://huicui.hebmu.edu.cn/EN/Y2023/V38/I3/241

Figures/Tables 4

Tab.1 Comparison of clinical and laboratory values between the two groups ( x -±s)

组别	例数		病程 (年)		BMI (kg/m²)		SUA (μmol/L)		ESR (mm/h)	CRP (mg/L)	TC (mmol/L)
GA组	45		4.91±4.76		27.30±3.80		520.71±113.23		11.72±13.64	10.29±17.23	4.12±0.79
对照组	35		-		23.05±1.81		313.54±87.57		3.40±0.64	1.47±0.62	3.87±0.63
$t$ 值			-		-6.130		-8.940		-2.200	-2.990	-4.400
$P$ 值			-		<0.01		<0.01		0.031	<0.01	<0.01
组别		TG (mmol/L)		LDL (mmol/L)		HDL (mmol/L)		SBP (mmHg)		FMD (%)	CIMT (mm)
GA组		1.64±0.88		2.55±0.74		1.19±0.26		117.93±8.46		9.35±2.94	0.69±0.15
对照组		1.25±0.29		2.18±0.48		1.24±0.12		114.51±6.69		13.49±1.02	0.66±0.07
$t$ 值		-2.120		-2.570		0.960		-3.680		7.950	-1.160
$P$ 值		0.043		0.012		0.339		0.214		<0.01	0.249

Tab.1 Comparison of clinical and laboratory values between the two groups ( x -±s)

组别	例数		病程 (年)		BMI (kg/m²)		SUA (μmol/L)		ESR (mm/h)	CRP (mg/L)	TC (mmol/L)
GA组	45		4.91±4.76		27.30±3.80		520.71±113.23		11.72±13.64	10.29±17.23	4.12±0.79
对照组	35		-		23.05±1.81		313.54±87.57		3.40±0.64	1.47±0.62	3.87±0.63
$t$ 值			-		-6.130		-8.940		-2.200	-2.990	-4.400
$P$ 值			-		<0.01		<0.01		0.031	<0.01	<0.01
组别		TG (mmol/L)		LDL (mmol/L)		HDL (mmol/L)		SBP (mmHg)		FMD (%)	CIMT (mm)
GA组		1.64±0.88		2.55±0.74		1.19±0.26		117.93±8.46		9.35±2.94	0.69±0.15
对照组		1.25±0.29		2.18±0.48		1.24±0.12		114.51±6.69		13.49±1.02	0.66±0.07
$t$ 值		-2.120		-2.570		0.960		-3.680		7.950	-1.160
$P$ 值		0.043		0.012		0.339		0.214		<0.01	0.249

Tab.2 Correlation analysis between FMD and other variables

	FMD
	$r$ 值	$P$ 值
BMI(kg/m²)	-0.158	0.300
SUA(μmol/L)	-0.393	0.007
ESR(mm/h)	-0.219	0.149
CRP(mg/L)	-0.322	0.030
TC(mmol/L)	0.273	0.069
TG(mmol/L)	-0.180	0.238
LDL(mmol/L)	0.124	0.416
HDL(mmol/L)	0.224	0.139
SBP(mmHg)	-0.242	0.109
CIMT(mm)	-0.458	0.001
病程	-0.431	0.003

Tab.2 Correlation analysis between FMD and other variables

	FMD
	$r$ 值	$P$ 值
BMI(kg/m²)	-0.158	0.300
SUA(μmol/L)	-0.393	0.007
ESR(mm/h)	-0.219	0.149
CRP(mg/L)	-0.322	0.030
TC(mmol/L)	0.273	0.069
TG(mmol/L)	-0.180	0.238
LDL(mmol/L)	0.124	0.416
HDL(mmol/L)	0.224	0.139
SBP(mmHg)	-0.242	0.109
CIMT(mm)	-0.458	0.001
病程	-0.431	0.003

Tab.3 Regression analysis of FMD and SUA

组别		偏回归系数	标准误	标准化偏回归系数	$t$ 值	$P$ 值
GA	常数项	14.677	1.941		7.560	<0.01
	SUA	-0.010	0.004	-0.393	-2.810	0.008

Tab.3 Regression analysis of FMD and SUA

组别		偏回归系数	标准误	标准化偏回归系数	$t$ 值	$P$ 值
GA	常数项	14.677	1.941		7.560	<0.01
	SUA	-0.010	0.004	-0.393	-2.810	0.008

Fig.1 Univariate regression analysis of FMD and SUA

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