Table of Content

20 March 2023, Volume 38 Issue 3

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Correlation between pathological changes and serum ferritin and iron levels in nonalcoholic fatty liver disease: A meta-analysis

Cao Yumeng, Zhang Haiyan, Liu Lixin

2023, 38(3):  197-207.  doi:10.3969/j.issn.1004-583X.2023.03.001

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Objective To systematically evaluate the correlation between pathological changes and serum ferritin and iron levels in nonalcoholic fatty liver disease (NAFLD). Methods Chinese and English literatures form PubMed, China National Knowledge Internet (CNKI), VIP, Wanfang Data, Cochrane Library, published up to December 2021, regarding the correlation between pathological changes and serum ferritin and iron levels in NAFLD, were enrolled. Secondary screening, quality assessment and data extraction were performed, and then Stata12.0 software was used for meta-analysis. Results Thirty-two articles were included, representing 4 177 patients. Meta-analysis showed that the serum ferritin ( S M D=0.93, 95% C l: 0.85-1.01, P=0.000) and serum iron levels ( S M D=0.57, 95% C l: 0.37-0.76, P=0.000) in NAFLD group were higher than those in the control group. Compared with patients with simple fatty liver, the serum ferritin ( S M D=0.59, 95% C l: 0.41-0.78, P=0.000) in patients with nonalcoholic steatohepatitis was increased, and but no statistically significant difference in serum iron ( S M D=0.14, 95% C l: 0.00-0.29, P=0.057). Conclusion The presence of NAFLD correlates with increased serum ferritin and iron levels, and the pathological changes of NAFLD correlates positively with serum ferritin and iron levels. The causal relationship of the threes in NAFLD and the pathogenesis of NAFLD should be further investigation and verification in clinical.

Meta-analysis of the effect of robot-assisted and free-handed pedicle screw placement in spinal diseases

Li Yang, Du Yibin

2023, 38(3):  208-215.  doi:10.3969/j.issn.1004-583X.2023.03.002

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Objective To compare the clinical effects of robot-assisted versus free-handed pedicle screw placement in spinal surgery, and to provide a theoretical reference for the future development of spinal surgery. Methods We searched related case-control studies published from February 2011 to February 2021, in six databases including Pubmed, Cochrane Library, CNKI, Embase, WF and VIP. According to Chinese and English retrieval strategies, retrieved eligible 418 documents, further screened and finally included 13 documents. In this paper, we extracted and analyzed the data by Review manager 5.3 software. Results When pedicle screws were used to placed, the accuracy of robot-assisted placement was higher than that of free-hand fluoroscopy-guided (95% C I=2.19-3.61, P<0.01). The time required for robot-assisted and fluoroscopy-guided was similar (95% C I=-0.18-33.96, P=0.05), but the other indicators were comparable between groups. Conclusion Robot-assisted screw placement is more accurate than traditional freehand screw placement, which is a more accurate and safe choice for the treatment of spinal diseases. Moreover, the operation time, radiation dose and time of robot-assisted tend to decline, which will play an important role in spinal surgery in the future.

Characteristics of cognitive function and corresponding factors in young and middle-aged patients with type 2 diabetes with obstructive sleep apnea hypopnea syndrome

Yang Minxing, Sun Lu, Ye Yun, Xu Wendong, Huang Xiaolin, Zhang Haiyun, Xu Yinglei

2023, 38(3):  216-220.  doi:10.3969/j.issn.1004-583X.2023.03.003

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Objective To explore the characteristics of cognitive function and corresponding factors in young and middle-aged patients with type 2 diabetes mellitus (T2DM) with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A total of 364 young and middle-aged T2DM patients with OSAHS hospitalized in the Endocrine Metabolism Department of the Third Affiliated Hospital of Soochow University from January 2020 to December 2021 were enrolled, and the patients were allocated to the cognitive impairment (CI) group ( n=187) and normal cognitive (NC) group ( n=177) based on Addenbrooke’s Cognitive Examination III (ACE-III) in Chinese version. The clinical data of the two groups were compared. Multivariate Logistic regression analysis was applied to explore the independent factors of cognitive dysfunction in middle-aged and young T2DM patients with OSAHS. Two-way ANOVA of body mass indexes (BMI) and apnea hypopnea index (AHI) on ACE-Ⅲ scores were performed. Results The 187 (51.4%) patients had CI. The total score of ACE -Ⅲ and five cognitive dimensions in CI group were lower than those in NC group ( P<0.05). Multivariate Logistic regression analysis showed that education years, AHI, BMI and oxygen desaturation index were independent risk factors for CI (all P<0.05). The ACE-Ⅲ scores difference between different BMI groups were statistically significant regardless of the AHI ( F=9.732, P=0.000). ACE-Ⅲ scores of patients with different AHI decreased gradually increase in BMI, and the interaction effects of BMI and AHI on ACE-Ⅲ score were insignificant ( F=1.198, P=0.311). Conclusion The incidence of CI in middle-aged and young patients with T2DM and OSAHS is higher, BMI, AHI, oxygen desaturation index, as well as education years may be risk factors for CI in the population.

Value of Mini Mental State Examination and Montreal Cognitive Assessment in screening mild vascular cognitive impairment at post-stroke

Jia Yangjuan, Han Ning, Guo Hui, Li Yanpeng, Li Cancan, Li Jianguo

2023, 38(3):  221-226.  doi:10.3969/j.issn.1004-583X.2023.03.004

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Objective To investigate the clinical application value of the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) in screening mild vascular cognitive impairment (mVCI) following acute ischemic stroke. Methods It was a cross-sectional study involving 135 patients with the first onset of acute ischemic stroke from October 2019 to October 2021. They were divided into mVCI group and non-cognitive impairment (NCI) group according to mVCI diagnostic criteria. Neuropsychological conditions were assessed by MMSE and MoCA, and their cut-off values were determined based on the plotted receiver operating characteristic (ROC) curve. MMSE and MoCA items were compared by the t test and Mann-Whitney U test, and their effect on screening mVCI was compared. Results A total of 135 patients were recruited, involving 56 cases in mVCI group and 79 cases in NCI group. The optimal cut-off values of MMSE and MoCA were 25/26, and 22/23, respectively. The area under the curve (AUC) of MMSE and MoCA was 0.737 and 0.847, respectively. The total scores of MMSE and MoCA in 51/135 patients (86.4%) were lower than the cut-off values, with 37/51 (72.5%) patients in the mVCI group and 14/51 (27.5%) patients in the NCI group. Totally 30/135 patients (39.5%) had normal total scores of MMSE, while their MoCA scores were lower than the cut-off values. Among them, 15/30 (50.0%) patients were in the mVCI group and 15/30 (50.0%) patients were in the NCI group. Totally 8/135 patients (13.6%) had normal total scores of MoCA, while their MMSE scores were lower than the cut-off values. Among them, 1/8 (12.5%) patients were in the mVCI group, and 7/8 (87.5%) patients were in the NCI group. There were significant differences in the scores of MMSE domains of recall, attention and language between groups ( P<0.05), and those of MoCA domains of visuospatial executive function, abstraction and delayed recall and orientation ( P<0.05). Conclusion The MoCA is more sensitive than the MMSE in screening mVCI after acute ischemic stroke, especially in visuospatial and executive function. Longitudinal studies are required to establish the prognostic values of MMSE and MoCA in mVCI after acute stroke.

Efficacy and safety of recombinant tissue plasminogen activator in patients with acute mild ischemic stroke

Yao Meifen, Ding Gangyu, Xu Jianhua, Wang Guojiang

2023, 38(3):  227-231.  doi:10.3969/j.issn.1004-583X.2023.03.005

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Objective To observe the efficacy and safety of recombinant tissue plasminogen activator (rt-PA) on the treatment of acute mild ischemic stroke with a baseline National Institute of Health Stroke scale (NIHSS) score ≤3.Methods A total of 187 patients with acute mild ischemic stroke who were hospitalized in the Department of Neurology, Shanghai Jiading District Central Hospital from January 2020 to December 2021 with a baseline NIHSS score of ≤3 and the duration from the onset to medical visit ≤4.5 hours were retrospectively analyzed. According to the use of intravenous thrombolysis with rt-PA or not, they were divided into intravenous thrombolysis group ( n=92) and non-intravenous thrombolysis group ( n=95). The clinical data of the two groups were compared to determine the efficacy and safety of rt-PA on acute mild ischemic stroke. Results There were no significant differences in the gender, smoking history, drinking history, previous history, the of Trial Org 1072 in Acute Stroke Treatment (TOAST) classification, low density lipoprotein cholesterol, triglyceride, total cholesterol, blood homocysteine, urea nitrogen, blood creatinine, glycosylated hemoglobin, baseline and 24-hour NIHSS score, the proportion of NIHSS score increased by ≥1 point compared with the 7^th day on the 14^th day of the onset, modified Rankin Scale (mRS) score on the 90^th day of the onset, and the proportion of mRS score decreased by ≥1 point compared with the 7^th day on the 90^th day of the onset between groups ( P>0.05). Compared with the non-intravenous thrombolysis group, patients in the intravenous thrombolysis group were younger, and the NIHSS score was lower on the 7^th and 14^th days after the onset. The proportion of patients with NIHSS score decreased by ≥ 1 point compared with the baseline on the 24 hours, 7^th and 14^th days after the onset of the disease was higher in the intravenous thrombolysis group and the difference was statistically significant ( P≤0.05). No symptomatic intracranial hemorrhage or death occurred in both groups. The proportion of intracranial hemorrhage transformation in the intravenous thrombolysis group was significantly higher than that in the non-intravenous thrombolysis group ( P<0.05). The intracranial hemorrhage transformations in the intravenous thrombolysis group were all asymptomatic hemorrhagic transformations, which did not cause aggravation of clinical symptoms or changes in NIHSS scores.Conclusion The use of rt-PA in intravenous thrombolysis in patients with acute mild ischemic stroke (NIHSS score ≤ 3 points) can improve the neurological deficit in the acute stage, but increases the risk of intracranial hemorrhage conversion. It does not cause serious adverse events.

Correlation of pre-hospital heparinization combined with one pack of drugs and revascularization in patients with acute ST-segment elevation myocardial infarction

Yan Haiyan, Ding Yankui, JiaHongjing , WangJiyuan , Zhang Xuewei, Hu Yinjie, Chu Junjie, Hu Hongyan, Guo Gaofeng

2023, 38(3):  232-236.  doi:10.3969/j.issn.1004-583X.2023.03.006

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Objective To explore the value of pre-hospital heparinization combined with one pack of drugs(Aspirin enteric-coated tablets 300 mg, Clopidogrel 300 mg, Atorvastatin tablets 40 mg) in patients with acute ST-segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PPCI).Methods Totally 77 patients with acute STEMI who underwent PPCI in our hospital from June 2021 to August 2022 were enrolled as subjects. All subjects were allocated to observation group ( n=21) and control group ( n=56) according to the pre-hospital and in-hospital heparinization combined with one package of drugs. In the observation group, after being diagnosed as STEMI by the Chest Pain Center via contacting WeChat Group, the patient was intravenously injected with 5,000 U of ordinary heparin in combination with one pack of drugs immediately. In the control group, after the patient came to the emergency department of our hospital and diagnosed as STEMI, the patient was given 5,000 U of unfractionated heparin (UFH) combined with one pack of drugs, and immediately started PPCI in the catheter room. The baseline characteristics, immediate coronary angiography, serological indicators, major postoperative cardiovascular adverse events and reflow status in the thrombolysis in myocardial infarction (TIMI) test were compared between the two groups. Results There were no significant differences in gender, age, hypertension, diabetes, hyperlipidemia, symptom onset time and other baseline data between the two groups ( P>0.05). There was no significant difference between the two groups in left descending artery (LAD), left circumflex artery(LCX), right coronary artery(RCA) and other infarction related artery (IRA) and TIMI2 grade ( P>0.05),TIMI grades 0~1 and 3 were compared, and the difference was statistically significant ( P<0.05). Postoperative values of creatine kinase MB (CK-MB), platelet / lymphocyte ratio(PLR) and monocyte / high-density lipoprotein cholesterol (HDL-C) ratio (MHR) in both groups were obviously lower than those before surgery, and the observation group was significantly lower than the control group ( P<0.05). There were no significant differences in the probability of postoperative cardiac death, heart failure, stroke, recurrent angina, and revascularization between the two groups ( P>0.05). However, the probability of bleeding in the observation group was significantly lower than that in the control group ( P<0.05).The postoperative no-reflow rate in the control group was 19.6%, and there was no no-reflow in the observation group, indicating the no-reflow rate in the control group was significantly higher than the observation group ( P<0.05).Conclusion The application of pre hospital heparin combined with one pack of drugs in patients with STEMI can not only effectively improve the revascularization rate of IRA, improve myocardial perfusion and serological indicators, but also significantly reduce the incidence of postoperative no-reflow and cardiovascular adverse events, improve prognosis and promote recovery.

Mycoplasma pneumoniae infection in Chengdu in 2021: An epidemiological study

Zhang Dawei, Li Xin, Sun Guifeng

2023, 38(3):  237-240.  doi:10.3969/j.issn.1004-583X.2023.03.007

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Objective To explore the epidemic characteristics and changing trend of mycoplasma pneumoniae (MP) infection in Chengdu in 2021, thus providing references for clinical practice.Methods A total of 10,012 patients in Chengdu, Sichuan Province with respiratory tract infection and examined with a passive agglutination assay for detecting MP antibodies (MP-Ab) in 2021 were recruited. The differences in MP infections of different age groups, male or female patients and at different seasons were observed.Results Totally 3084/10,012 (30.80%) MP-positive samples were detected. Stratified by the sex, the positive rate of MP infection in male patients was significantly lower than that of females (25.84% vs 36.12%, χ²=124.00, P<0.05). The positive rate of MP in juveniles was significantly higher than that in adults and middle-aged and elderly people (43.53% vs 33.83%, 14.03%, χ²=790.13, P<0.05). The positive rate of MP increased with aging in patients of 0-18 years. The highest and lowest positive rate of MP in minors were detected in those aged 15-17 years (61.61%) and infants younger than 1 year (4.08%), respectively. A significant difference in the positive rate of MP was detected in age groups of minors (χ²=388.27, P<0.05). Stratified by the season, the highest and lowest positive rate of MP were detected in autumn (33.67%) and summer (27.01%), respectively. No significant difference was detected in the positive rate of MP between winter and spring (χ²=1.16, P>0.05), which was significantly different between summer and autumn (χ²=28.23, P<0.05). November was the month with the highest positive rate of MP in the whole year (35.85%), and the lowest was February (21.79%). Conclusion The positive rate of MP in female is higher than that in male. Preschool children, school-age children and adolescents are susceptible populations of MP infection. In autumn and the alternating seasons of autumn and winter (i.e., September to December), MP infection is highly prevalent. MP is one of the important pathogens causing respiratory tract infection in Chengdu in 2021. Targeted prevention and control measures should be taken for susceptible populations according to the epidemiological characteristics of MP infection. Meanwhile, health education should be strengthened to prevent and control the spread of MP infection.

Correlation between vascular endothelial function and serum uric acid in gouty arthritis

Shen Xuejiao, Li Yan, Wang Ting, Wang Yuan

2023, 38(3):  241-244.  doi:10.3969/j.issn.1004-583X.2023.03.008

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Objective To explore the effect of ultrasound (US) on the impairment of vascular endothelial function (VEF) in patients with gouty arthritis (GA) and its correlation with serum uric acid (SUA) levels.Methods This study included 45 GA patients (the GA group) and 35 healthy subjects (the control group). The key observation was laboratory data (SUA, high density lipoprotein [HDL], low-density lipoprotein [LDL], total cholesterol [TC], triglycerides [TG], C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]), height, weight, body mass index (BMI), disease duration. The right carotid intima media thickness (CIMT), flow-mediated dilation (FMD) of right upper limb were measured by US between GA group and control group. The correlation between FMD and SUA, other variables in the GA group was analyzed.Results Compared with the control group, BMI, SUA, ESR, CRP, TC, TG, LDL in the GA group were significantly increased, while FMD was significantly decreased (P<0.05). FMD was negatively correlated with SUA, CRP, CIMT and disease duration in GA group ( r=-0.393, -0.322, -0.458, -0.431). Conclusion GA can cause damage to VEF in patients, which is related to SUA, CRP and the disease duration. US can evaluate VEF, which is of great value in the prevention of cardiovascular diseases.

Forecast value of neutrophil count combined with serum uric acid on myocardial injury after acute carbon monoxide poisoning

Liu Bin, Zhai Guilan, Sun Jufeng

2023, 38(3):  245-249.  doi:10.3969/j.issn.1004-583X.2023.03.009

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Objective To investigate the predictive value of neutrophil count combined with serum uric acid (SUA) on myocardial injury in patients with acute carbon monoxide poisoning (ACOP). Methods A total of 114 ACOP patients who were hospitalized in the Department of Gastroenterology at the First Affiliated Hospital of Jinzhou Medical University from January 2021 to June 2022 were enrolled. Patients were allocated to a myocardial injury group ( n=72) and a non-myocardial injury group ( n=42) based on whether there was an increase in cardiac troponin I (cTnI) within 24 hours of admission. Clinical data of two sets were compared. Multivariate binary logistic regression analysis was employed to assess independent risk factors for myocardial injury in ACOP patients. Receiver operating characteristic curve analysis was performed to analyze the predictive value of relevant indicators in these patients. Results There was no significant difference in gender, hypertension history, diabetes history, smoking history and body temperature at admission between the two groups ( P>0.05). Compared with the non-myocardial injury group, the myocardial injury group had significantly higher age, neutrophil count levels, blood creatinine levels, and higher SUA levels ( P<0.05). Binary multivariate logistic regression analysis showed that age, neutrophil count, and SUA were independent risk factors for myocardial injury in ACOP patients. The cutoff values of neutrophil count and SUA for predicting myocardial injury in ACOP patients were 9.55×10⁹/L and 325 μmol/L, respectively. The sensitivity and specificity of neutrophil count combined with SUA in predicting myocardial injury in ACOP patients were 68.1%, 73.8%, respectively, and 0.737 for the area under the curve (AUC), 0.419 for Jordan index. Conclusion Age, neutrophil count, and SUA are independent risk factors for myocardial injury in ACOP patients. The combination of neutrophil count and SUA has certain value in predicting myocardial injury in ACOP patients.

Predictive values of platelet count and coagulation index in the 28-day survival of sepsis patients

Tang Aijun, Wang Liwei

2023, 38(3):  250-254.  doi:10.3969/j.issn.1004-583X.2023.03.010

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Objective To measure platelet count (PLT) and coagulation indexes in sepsis patients at admission, and to analyze the predictive value of PLT and coagulation indexes in the 28-day survival of sepsis patients. Methods It was a retrospective study involving 91 sepsis patients admitted to Wusong Central Hospital from January 2019 to January 2021. The first diagnosis time of in the intensive care unit, and the survival statue within 28 days were considered as the starting and end point of the study, respectively. According to the 28-day survival status of sepsis patients, they were assigned into the death group ( n=31) and the survival group ( n=60). The predictive value of PLT and coagulation indexes in the 28-day survival status of sepsis patients was analyzed. Results There were 30/91 (32.97%) sepsis patients died within 28 days. The fibrinogen (FIB) and PLT levels in the death group were significantly lower than those in the survival group at admission, while the prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D), Quick Sequential Organ Failure Assessment (qSOFA) scores, Sequential Organ Failure Assessment (SOFA) scores, Acute Physiology and Chronic Health Assessment System II were significantly higher than those in the survival group (all P<0.05). Cox regression analysis showed that FIB, PLT, PT, APTT and D-D were independent risk factors for 28-day mortality in sepsis patients (all P<0.05). Receiver operating characteristic analysis showed that the area under the curve (AUC) of FIB, PLT, PT, APTT, and D-D at admission in predicting the 28-day survival of sepsis was larger than 0.80, indicating a certain predictive value. Conclusion The FIB, PLT, PT, APTT, and D-D have a certain value in predicting the 28-day survival status of sepsis patients.

Risk of violence in schizophrenia patients with obsessive-compulsive thinking versus behaviors: A comparative study

Lin Xiaodong, Qu Junmin, Yu Jun, Li Jinming

2023, 38(3):  255-259.  doi:10.3969/j.issn.1004-583X.2023.03.011

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Objective To compare the violent risk and clinical treatment of schizophrenia with obsessive-compulsive thinking versusobsessive-compulsive behavior. Methods A total of 46 outpatients with schizophrenia and obsessive-compulsive thinking and 46 outpatients with schizophrenia and obsessive-compulsive behavior were recruited. They were all treated with antipsychotics and anti-compulsions drugs for 12 weeks. Before the treatment, and at 4, 8 and 12 weeks of treatment, patients were assessed using the the Positive and Negative Symptoms Scale (PANSS) for mental symptoms, the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)for obsessive-compulsive symptoms, and the modified explicit aggressive behavior scale (MOAS) for the violent risk.Results Logistic regression showed that obsessive-compulsive thinking ( O R=13.811, P=0.001), unstable psychotic symptoms ( O R=34.183, P=0.002) and male sex ( O R=4.644, P=0.034) were the risk factors for violence in schizophrenia patients with obsessive-compulsive thinking and behavior. After 12 weeks of treatment, the total scores of PANSS, Y-BOCS, and MOAS at each time point in both groups were gradually reduced with time ( P<0.05). There were no significant differences in the total PANSS scores between groups ( F=1.52, P=0.221). There were significant differences in the total scores of Y-BOCS ( F=7.179, P=0.009) and MOAS ( F=6.067, P=0.016) between groups. Significant main effect of time ( P<0.001) and interaction effect ( P<0.05) were detected in the total scores of PANSS, Y-BOCS and MOAS between groups. The declines of the total scores of Y-BOCS and MOAS were more pronounced in schizophrenia patients with obsessive-compulsive thinking than those with obsessive-compulsive behavior. At 8 and 12 weeks, the total scores of Y-BOCS were significantly higher in schizophrenia patients with obsessive-compulsive behavior than those with obsessive-compulsive thinking ( P<0.01). Before the treatment and at 4 weeks of treatment, the total scores of MOAS were significantly higher in schizophrenia patients with obsessive-compulsive thinking than those with obsessive-compulsive behavior ( P<0.01). Conclusion The violent risk is significantly higher in schizophrenia with obsessive-compulsive thinking than schizophrenia with obsessive-compulsive behavior. Antipsychotics combined with anti-compulsive drugs can reduce the violent risk in schizophrenic patients with obsessive-compulsive symptoms.

Cryptococcal meningoencephalitis with unstable gait as the initial symptom: A case report

Wang Yao, Huang Pengru, Zeng Zhaohao, Luo Hong, Cen Haimei, Luo Bin, Zhang Yu

2023, 38(3):  260-263.  doi:10.3969/j.issn.1004-583X.2023.03.012

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Objective To investigate the clinical characteristics of patients with cryptococcal meningoencephalitis with unstable gait as the initial symptom. Methods The clinical datas of a cryptococcal meningoencephalitis patient with unstable gait as the initial symptom were analyzed.Results A 45-year-old male presented with unstable gait two years ago, and the symptoms worsened progressively, complicated with decreased memory and delayed response. Brain MR scans showed dilation of the ventricular system, and cerebrospinal fluid examination revealed cryptococcal infection. After treatment with amphotericin B and fluorocytosine, the clinical symptoms improved. Conclusion Cryptococcal meningoencephalitis usually has an insidious onset, and unstable gait may be the initial symptom, which should be paid attention in clinical practice.

One case of neuromyelitis optica with positive antithyroid antibody and literature review

Wang Zijia, Wang Jiuxue, Wang Tianjun

2023, 38(3):  264-267.  doi:10.3969/j.issn.1004-583X.2023.03.013

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Objective To investigate the correlation between antithyroid antibodies (ATAbs) and neuromyelitis optica (NMO). Methods The clinical data and antibody detection results of one NMO patient with positive ATAbs were retrospectively analyzed, and the related literatures were reviewed. Results The patient, 61 years old female, left limb numbness for 10 days, aggravation for 3 days. The results of cerebrospinal fluid and serum indicated that aquaporin-4 immunoglobulin G (AQP4-IgG)-positive in cerebrospinal fluid and serum was 1∶1 and 1∶100, respectively. The diagnosis was NMO. Conclusion NMO and thyroid-related diseases are often associated, and more studies are needed to draw definite conclusions about their relationship.

Evaluation and cognitive training of eye tracking technology in right-sided unilateral neglect patients: A case report and literature review

Zhao Yue, Zhang Shaohua, Zhao Zhenbiao, Yan Yanning, Sun Zengxin, Wang Xiaohan, Lyu Peiyuan, Yin Yu

2023, 38(3):  268-272.  doi:10.3969/j.issn.1004-583X.2023.03.014

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Objective To explore the rehabilitation options for patients with right-sided unilateral neglect complicated with severe cognitive impairment after stroke. Methods Retrospective analysis of one patient with severe cognitive impairment and aphasia accompanied by right-sided unilateral neglect after stroke was conducted for evaluation and cognitive training, and literature review was conducted. Results Eye tracking technology, non-verbal cognitive function assessment and behavioral observation could objectively evaluate the degree of cognitive impairment of patients. Through comprehensive rehabilitation training such as eye tracking training and transcranial direct current stimulation, certain therapeutic effects had been achieved. Conclusion Eye tracking technology combined with cognitive training provides new ideas for the rehabilitation of patients with severe cognitive impairment.