关键词: 肺栓塞, 肿瘤, 肝素

Abstract: Objective  To explore the clinical feature of malignant tumor accompanied with pulmonary embolism (PE)， which may provide the evidence for early prevention， diagnosis and treatment. Methods  Clinical data of patients diagnozed with PE and tumor during from January 2014 to December 2016 were retrospectively analyzed. Results  In 95 cases of tumor with PE， the average age was (62.7±11.8) years， 56 cases (58.9%) were ≥60 years， 56 cases were with pathology of adenocarcinoma， 49 cases were complicated with lower limb DVT， 48 cases were complicated with hypertension， 18 cases were complicated with diabetes， and 14 cases were complicated with hypercholesterolemia， and 12 cases were complicated with hyperuricemia， 18 cases were diagnozed of PE before tumor， 30 cases diagnozed PE and tumor simultaneously， 47 cases diagnozed PE after tumor.  30 cases suffered from PE during chemotherapy or targeted medication. The therapies were several combinations， as 16 cases received chemotherapy with platinum drugs， 2 PE patients received thrombolytic therapy combined with low molecular weight heparin (LMWH)， 67 cases LMWH maintenance anticoagulation therapy， 22 cases LMWH bridging anticoagulation with warfarin therapy， 3 patients anticoagulation therapy of rivaroxaban.  92 (96.8%) patients were relieved after anticoagulation therapy.Conclusion  Age  ≥60 years， pathology of adenocarcinoma， combined DVT，with  in 3 months after diagnosis of malignant tumor are at high risk of PE. Early diagnosis， prevention and treatment of patients with malignant tumor complicated with PE are key factors to reduce the mortality and improve the prognosis.

Key words: pulmonary embolism, tumor, heparin