血清胱抑素C、纤维蛋白原和C-反应蛋白水平与颅内动脉瘤发生及破裂的关系

doi:10.3969/j.issn.1004-583X.2020.06.009

临床荟萃

血清胱抑素C、纤维蛋白原和C-反应蛋白水平与颅内动脉瘤发生及破裂的关系

兰州大学第二医院检验科，甘肃兰州 731000

出版日期:2020-06-20 发布日期:2020-05-18
通讯作者: 孟灵，Email：ml3651990@163.com

The relationship between the levels of serum cystatin C, fibrinogen and Creactive protein and the occurrence and rupture of intracranial aneurysms

Laboratory Department, the Second Hospital of Lanzhou University, Lanzhou 731000, China

Online:2020-06-20 Published:2020-05-18
Contact: Corresponding author：Meng Ling, Email：ml3651990@163.com

摘要/Abstract

摘要：
目的探讨血清胱抑素C(serum cystatin C, CysC)、纤维蛋白原(fibrinogen, FBG)和C反应蛋白(Creactive protein, CRP)水平与颅内动脉瘤发生及破裂的关系。方法选取颅内动脉瘤患者100例分为破裂组(n=54)和未破裂组(n=46)，50例健康体检者为对照组。收集患者血液和脑脊液并检测血清CysC、FBG和CRP的含量。结果颅内动脉瘤患者中饮酒、吸烟、高血压和动脉粥样硬化比例明显高于对照组，且破裂组年龄≥60岁、男性、饮酒、吸烟、糖尿病、高血压及动脉粥样硬化占比更高，差异具有统计学意义 (p<0.05)。与对照组相比，颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP 含量显著升高(P<0.05)。结论颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP 含量异常升高，且CysC、FBG和CRP 含量与颅内动脉瘤破裂有关。

关键词: 颅内动脉瘤, 血清胱抑素C, 纤维蛋白原, C-反应蛋白

Abstract: Objective To investigate the relationship between the levels of serum cystatin C (CysC), fibrinogen (FBG) and Creactive protein (CRP) and the occurrence and rupture of intracranial aneurysms.Methods A total of 100 patients with intracranial aneurysms were divided into the ruptured group (n=54) and the unruptured group (n=46), and 50 healthy people were selected as the control group. Blood and cerebrospinal fluid samples were collected and the levels of serum CysC, FBG and CRP were measured. Results Among patients with intracranial aneurysms, the proportion of drinking, smoking, hypertension and atherosclerosis was significantly higher than that of the control group, and the proportion of age ≥60 years old, male, drinking, smoking, diabetes, hypertension and atherosclerosis in the ruptured group were higher(P<0.05). Compared with the control group, the levels of CysC, FBG and CRP in the blood and cerebrospinal fluid of patients with intracranial aneurysms were significantly increased(P<0.05). Conclusion The levels of CysC, FBG and CRP in the blood and cerebrospinal fluid of patients with intracranial aneurysms are increased abnormally, and the levels of CysC, FBG and CRP are related to the rupture of intracranial aneurysms.

Key words: intracranial aneurysm, serum cystatin C, fibrinogen, Creactive protein

杨婧，朱金芬，马澜，孟灵. 血清胱抑素C、纤维蛋白原和C-反应蛋白水平与颅内动脉瘤发生及破裂的关系[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2020.06.009.

Yang Jing, Zhu Jinfen, Ma Lan, Meng Ling. The relationship between the levels of serum cystatin C, fibrinogen and Creactive protein and the occurrence and rupture of intracranial aneurysms[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2020.06.009.

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https://huicui.hebmu.edu.cn/CN/Y2020/V35/I6/525

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血清胱抑素C、纤维蛋白原和C-反应蛋白水平与颅内动脉瘤发生及破裂的关系

The relationship between the levels of serum cystatin C, fibrinogen and Creactive protein and the occurrence and rupture of intracranial aneurysms

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