中性粒细胞胞外诱捕网在免疫球蛋白A血管炎发病机制中的研究进展

doi:10.3969/j.issn.1004-583X.2024.12.015

摘要/Abstract

摘要：

免疫球蛋白A血管炎(immunoglobulin A vasculitis,IgAV)由含有IgA的免疫复合物在皮肤、肾脏和胃肠道的小血管壁中滞留引起。IgAV的发病机制尚未完全阐明,但近年来研究表明,中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)的过度形成可能在其病理过程中发挥重要作用。越来越多的证据表明,IgAV患者的外周血循环及其受累的皮肤、肾脏和胃肠道组织中普遍存在NETs,这些NETs与疾病的活动性密切相关。本文旨在综述NETs在IgAV发病机制中的潜在作用,并探讨其作为评估IgAV疾病活动性生物标志物的应用前景。

关键词: IgA血管炎, 胞外诱捕网, 疾病活动性, 生物标志物

中图分类号:

R554.6

沈孟达, 邬秀娣. 中性粒细胞胞外诱捕网在免疫球蛋白A血管炎发病机制中的研究进展[J]. 临床荟萃, 2024, 39(12): 1141-1146.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2024.12.015

https://huicui.hebmu.edu.cn/CN/Y2024/V39/I12/1141

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中性粒细胞胞外诱捕网在免疫球蛋白A血管炎发病机制中的研究进展

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