临床荟萃 ›› 2020, Vol. 35 ›› Issue (12): 1067-1077.doi: 10.3969/j.issn.1004583X.2020.12.002

• 循证研究 • 上一篇    下一篇

ST段抬高型心肌梗死行冠状动脉介入治疗预后的影响因素meta分析

  

  1. 延安大学附属医院 急诊内科,陕西 延安  716000
  • 出版日期:2020-12-20 发布日期:2020-11-27
  • 通讯作者: 冯传杰,Email: thhhfcj1973@163.com

The factors influencing the prognosis of STsegment elevation myocardial infarction after coronary intervention A meta analysis

  1. Department of Emergency Medicine, Affiliated Hospital of  Yan'an University, Yan'an 716000, China
  • Online:2020-12-20 Published:2020-11-27
  • Contact: Corresponding author: Feng Chuanjie, Email: thhhfcj1973@163.com

摘要: 目的  综合评价行冠状动脉介入治疗术(PCI)的急性ST段抬高型心肌梗死(STEMI)患者术后发生心血管事件的影响因素。方法  收集相关病例对照试验数据,文献质量评分用NewcastleOttawa Scale( NOS)量表,数据分析用RevMan5.3。结果  STEMI患者PCI术后发生不良事件的影响因素:年龄,糖尿病,Killip分级≥2级,左心室射血分数(LVEF)值,维持高收缩压水平,急诊PCI启动时间,Gensini评分,左主干病变,病变支数≥2,高敏C反应蛋白(hsCRP),血浆N末端B型利钠肽前体(NTproBNP),肌酸激酶同工酶(CKMB),使用替罗非班,TIMI血流分级(P<0.01)。结论  高龄、合并糖尿病、术前killip分级≥2级、启动PCI时间延长、高Gensini评分、左主干病变、病变支数≥2、高hsCRP、高NTproBNP、高CKMB、TIMI血流分级≤2级是急性ST段抬高型心肌梗死PCI术后发生不良事件危险因素,术前高LVEF值、维持高收缩压水平和使用替罗非班是保护因素。

关键词: 心肌梗死, 血管成形术, 气囊, 冠状动脉, 手术后并发症, meta分析

Abstract: Objective  To systematically explore the risk factors for postoperative cardiovascular events in patients with acute STsegment elevation myocardial infarction (STEMI) undergoing coronary intervention.  Methods  The data of relevant casecontrol trials from 2010 to 2020 were collected. The Study quality evaluation with NewcastleOttawa Scale (NOS) scale. Metaanalysis on literatures was conducted by using RevMan 5.2 software. Results  Factors influencing adverse events after PCI in STEMI patients were advanced age, diabetes mellitus,Killip class ≥Ⅱ,EF values,maintenance of high systolic blood pressure, emergency PCI startup time, Gensini score,left main stem disease,multivessel disease≥2,hsCRP, NTproBNP,CKMB,intravenous tirofiban, TIMI flow grade(P<0.01).Conclusion  Older age,history of diabetes mellitus, Killip class ≥Ⅱ,high Gensini score,multivessel disease≥2, increased hsCRP levels, increased NTproBNP levels, increased CKMB levels and TIMI flow grade≤2 are independent risk factors for patients after primary PCI , While high preoperative EF values, high preoperative systolic pressure and intravenous tirofiban are protective factors.

Key words: myocardial infarction, percutaneous coronary intervention, cardiovascular adverse events, metaAnalysis

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