临床荟萃

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秋水仙碱中毒患者30例临床荟萃分析

  

  1. 1.青岛大学医学部 青岛 山东 266071; 2.青岛大学附属医院 重症医学科, 青岛 山东 266003
  • 出版日期:2020-04-20 发布日期:2020-04-16
  • 通讯作者: 苏媛,Email: doctorsuyuan@126.com

A metaanalysis of 30 cases of colchicine poisoning

  1. 1.Faculty of Medicine,  Qingdao University,  Qingdao 266071,  China; 2.Department of Intensive Care Unit,
    the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China
  • Online:2020-04-20 Published:2020-04-16
  • Contact: Corresponding author: Su Yuan, Email: doctorsuyuan@126.com

摘要: 目的  探讨秋水仙碱药物中毒的临床特征、治疗和预后,提高临床对该药物中毒的认识和重视。方法  结合我院近期收治的1例大剂量秋水仙碱中毒患者,检索近年来有关秋水仙碱中毒的文献资料(2003-2019年)共21篇,秋水仙碱中毒患者29例,共30例。结果  秋水仙碱中毒男性16例(53.3%),女性14例(46.7%);中毒原因为自杀19例(63.3%),长期服药治疗痛风11例(36.7%)。26例(86.7%)患者临床第一阶段表现为消化道症状;21例(70%)患者第二阶段表现为骨髓抑制及多器官功能障碍;19例(63.3%)患者度过危险期最终好转。检查结果示26例(86.7%)患者血常规、血凝常规、肝功能、肾功能指标异常。经过积极对症支持治疗,最终完全康复19例(63.3%),死亡11例(36.7%)。结论  如果药物剂量不适宜将会出现严重的中毒反应甚至死亡,也有一些人口服该药物自杀。

关键词: 秋水仙碱, 中毒, 临床表现, 治疗与转归

Abstract: Objective  To investigate the clinical characteristics,  treatment and prognosis of colchicine poisoning,  and to raise the clinically awareness and attention of colchicine poisoning.Methods  Totally 21 literature about colchicine poisoning in recent years (20032019)were reviewed,  and 29  cases of colchicine poisoning combined with one case admitted to the hospital recently were enrolled. Results  Colchicine poisoning was found in 16 males (53.3%) and 14 females (46.7%). A total of 19 suicides (63.3%) were caused by colchicine poisoning,  and 11 patients with poisoning (36.7%) were treated with longterm medication for gout. Totally 26 patients (86.7%) showed gastrointestinal symptoms in the first stage; 21 patients (70%) showed myelosuppression and multiple organ dysfunctions in the second stage;19 patients (63.3%) got better after dangerous period.The checking results showed that the blood routine,  blood coagulation routine,  liver function and kidney function were abnormal in 26 patients (86.7%). After active symptomatic supportive treatment,  19 cases (63.3%) recovered completely and 11 cases (36.7%) died.Conclusion  If the drug dosage is not suitable,  serious poisoning reaction or even death will occur, and some people also choose oral colchicine to commit suicide.

Key words: colchicine, poisoning, clinical manifestations, treatment and outcome